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Cortical Excitability and its Relationship with Clinical Symptoms in Alzheimer's Dementia.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Cortical Excitability and its Relationship with Clinical Symptoms in Alzheimer's Dementia./
作者:	Joseph, Shaylyn.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:	157 p.
附註:	Source: Masters Abstracts International, Volume: 83-06.
Contained By:	Masters Abstracts International83-06.
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28644522
ISBN:	9798496549431

Cortical Excitability and its Relationship with Clinical Symptoms in Alzheimer's Dementia.
Joseph, Shaylyn.

Cortical Excitability and its Relationship with Clinical Symptoms in Alzheimer's Dementia. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 157 p.

Source: Masters Abstracts International, Volume: 83-06.

Thesis (M.Sc.)--University of Toronto (Canada), 2021.

This item must not be sold to any third party vendors.

Electroencephalography (EEG) studies of Alzheimer's Dementia (AD) have shown evidence of cortical hyper-excitability, however, its relationship with cognition and neuropsychiatric symptoms (NPS) remains unclear. Objectives: First, we conducted a system review and meta-analyses to quantitatively synthesis the evidence of cortical excitability in AD and its relationship with clinical symptoms. Next, we compared dorsolateral prefrontal cortex (DLPFC) excitability between AD and older healthy individuals using transcranial magnetic stimulation paired with EEG and assessed its relationship with cognition and NPS in AD. Hypothesis: We hypothesized increased cortical excitability in AD would be inversely associated with cognition and positively associated with NPS. Results: There is increased motor cortex and DLPFC excitability in AD as compared to healthy individuals. Additionally, DLPFC excitability was inversely associated with global cognition and executive functioning, and positively associated with NPS burden in AD. Conclusions: These findings help in understanding the mechanisms underlying AD and its associated clinical symptoms.

ISBN: 9798496549431Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Alzheimer's dementia

Cortical Excitability and its Relationship with Clinical Symptoms in Alzheimer's Dementia.
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