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Characterizing Early Alzheimer's Disease and Disease Progression Using Noninvasive MRI.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Characterizing Early Alzheimer's Disease and Disease Progression Using Noninvasive MRI./
Author:	Duan, Wenna.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	113 p.
Notes:	Source: Dissertations Abstracts International, Volume: 83-02, Section: A.
Contained By:	Dissertations Abstracts International83-02A.
Subject:	Computer science. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28539952
ISBN:	9798534669039

Characterizing Early Alzheimer's Disease and Disease Progression Using Noninvasive MRI.
Duan, Wenna.

Characterizing Early Alzheimer's Disease and Disease Progression Using Noninvasive MRI. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 113 p.

Source: Dissertations Abstracts International, Volume: 83-02, Section: A.

Thesis (Ph.D.)--State University of New York at Binghamton, 2021.

This item must not be sold to any third party vendors.

ObjectivesAlzheimer's Disease (AD) has been one of the most suffering and death-threatening diseases among the world. This work is intended to identify potential diagnostic biomarkers of AD in order to detect the incipient stages of the disease and allow early intervention by using continuous arterial spin labeling (CASL) and Magnetization Transfer Rate (MTR) imaging techniques.Methods195 of the age and gender matching participants received Magnitude Resonance Imaging (MRI) scans, neuropsychological assessments and Modified Mini-Mental State Examination (3MSE) at baseline. Within all the subjects, three groups were formed for cross-sectional perfusion study: 58 normal cognition (NC), 50 mild cognitive impairment (MCI) and 40 AD subjects; 5 groups were formed for longitudinal perfusion study with repeated subjects: 19 stable-NC, 17 NC-to-MCI, 26 stable-MCI, 11 MCI-to-AD and 10 stable-AD scan pairs from in total 63 subjects; three groups were formed for cross-sectional MTR study: 20 NC, 18 MCI and 25 AD subjects; four groups were formed for longitudinal MTR study: 15 stable-NC, 12 NC-to-MCI, 12 stable-MCI and 14 MCI/AD-to-AD subjects. Perfusion and T1 maps were derived and compared both in voxel-level and regional-level via general linear model (GLM) (or generalized least square (GLS) if include repeated subjects). Correlation analysis, cox regression, LR predict model were also applied to test the reliability and sensitivity of the potential biomarkers. ResultsRegional group-level comparison showed that (1) perfusion dropped much quicker in diseased group than stable-NC group; (2) AD may attacks posterior cingulate extending to precuneus and the right side of hippocampus at first, then spread to the left side of hippocamps, and last strikes superior medial frontal region; (3) MTR further decreased in diseased group than stable-NC group.Conclusion Two promising biomarkers of AD: perfusion and MTR with a better group-level sensitivity than 3MSE were derived. With the disease progressing, higher decreasing rate of perfusion and MTR are expected starting from MCI and early AD stage.

ISBN: 9798534669039Subjects--Topical Terms:

523869
Computer science.
Subjects--Index Terms:

Alzheimer's disease

Characterizing Early Alzheimer's Disease and Disease Progression Using Noninvasive MRI.
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245 1 0 $a Characterizing Early Alzheimer's Disease and Disease Progression Using Noninvasive MRI.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2021
300 $a 113 p.
500 $a Source: Dissertations Abstracts International, Volume: 83-02, Section: A.
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520 $a ObjectivesAlzheimer's Disease (AD) has been one of the most suffering and death-threatening diseases among the world. This work is intended to identify potential diagnostic biomarkers of AD in order to detect the incipient stages of the disease and allow early intervention by using continuous arterial spin labeling (CASL) and Magnetization Transfer Rate (MTR) imaging techniques.Methods195 of the age and gender matching participants received Magnitude Resonance Imaging (MRI) scans, neuropsychological assessments and Modified Mini-Mental State Examination (3MSE) at baseline. Within all the subjects, three groups were formed for cross-sectional perfusion study: 58 normal cognition (NC), 50 mild cognitive impairment (MCI) and 40 AD subjects; 5 groups were formed for longitudinal perfusion study with repeated subjects: 19 stable-NC, 17 NC-to-MCI, 26 stable-MCI, 11 MCI-to-AD and 10 stable-AD scan pairs from in total 63 subjects; three groups were formed for cross-sectional MTR study: 20 NC, 18 MCI and 25 AD subjects; four groups were formed for longitudinal MTR study: 15 stable-NC, 12 NC-to-MCI, 12 stable-MCI and 14 MCI/AD-to-AD subjects. Perfusion and T1 maps were derived and compared both in voxel-level and regional-level via general linear model (GLM) (or generalized least square (GLS) if include repeated subjects). Correlation analysis, cox regression, LR predict model were also applied to test the reliability and sensitivity of the potential biomarkers. ResultsRegional group-level comparison showed that (1) perfusion dropped much quicker in diseased group than stable-NC group; (2) AD may attacks posterior cingulate extending to precuneus and the right side of hippocampus at first, then spread to the left side of hippocamps, and last strikes superior medial frontal region; (3) MTR further decreased in diseased group than stable-NC group.Conclusion Two promising biomarkers of AD: perfusion and MTR with a better group-level sensitivity than 3MSE were derived. With the disease progressing, higher decreasing rate of perfusion and MTR are expected starting from MCI and early AD stage.
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