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Assessing Biomarkers of Magnesium in the Diet and for Nutritional Status.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Assessing Biomarkers of Magnesium in the Diet and for Nutritional Status./
作者:	Ansu, Velarie Yaa Ankrah.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:	323 p.
附註:	Source: Dissertations Abstracts International, Volume: 83-02, Section: B.
Contained By:	Dissertations Abstracts International83-02B.
標題:	Epidemiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28548047
ISBN:	9798516977091

Assessing Biomarkers of Magnesium in the Diet and for Nutritional Status.
Ansu, Velarie Yaa Ankrah.

Assessing Biomarkers of Magnesium in the Diet and for Nutritional Status. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 323 p.

Source: Dissertations Abstracts International, Volume: 83-02, Section: B.

Thesis (Ph.D.)--Indiana University, 2021.

This item must not be sold to any third party vendors.

Objectives: To determine simple and accurate measures of dietary intake of magnesium (Mg) and Mg status as well as their reference ranges in healthy adult populations. To compare the reference range of healthy populations with the values for populations with diseases. To develop a protocol paper to compare the bioavailability of two dietary Mg supplements (MgCl2, MgO) in healthy adults as measured with ionized Mg (iMg+2) concentrations in whole blood, total Mg in urine, and serum Mg concentrations. Study 1 Methods: We searched OVID MEDLINE®, Cochrane Central Register of Controlled Trials, and EMBASE through 24 July 2020 to identify related articles. The reference range for our population-level study was estimated using a frequentist random-effects model. Study 2 Methods: Total dietary Mg intake obtained from 3-day food records was compared with iMg+2 and serum Mg concentrations from each of the three study visits. A linear mixed-effects model was fit with dietary Mg as the outcome variable, with fixed effects considered for iMg+2, serum Mg, treatment, and study visit. Age, gender, body mass index, and race were accounted for in the model. Study 3 Methods: We designed a double-blind, three-period crossover randomized controlled trial among healthy participants (n = 46) aged 18-65 years old. Study participants will be provided with 1) a placebo containing lemon juice and water, which will serve as the control; 2) magnesium oxide (NOW; NOW Foods, Bloomingdale, IL, USA, 300 mg elemental magnesium); and 3) magnesium chloride (Brand: Remag®; New Capstone Inc., Mooresville, NC, USA 300 mg elemental magnesium). Study 1 Results: Results from our healthy population data showed a reference range of 0.40-0.68 mmol/L for iMg+2. All of the ranges for the populations with diseases overlapped with our estimated reference range for iMg+2. We obtained a reference range of 0.72-1.0 mmol/L for serum Mg concentrations. Similarly, populations with diseases had measures that were within the reference range for serum Mg. Study 2 Results: No association was found between reported dietary Mg intake and iMg+2 (F = 0.18, p = 0.67). Similar results were found between dietary Mg intake and serum Mg (F = 3.02, p = 0.10). Conclusions: Our reference range captures population with disease ranges. This reference range may not be sensitive or specific for diagnosing Mg deficiency. We also found that iMg+2 may not be a measure of chronic Mg dietary intake. We expect that the study protocol will enable the evaluation of bioavailable Mg supplements using iMg+2. Our findings will support future research on magnesium deficiencies in the context of metabolic disease.

ISBN: 9798516977091Subjects--Topical Terms:

568544
Epidemiology.
Subjects--Index Terms:

Bioavailability

Assessing Biomarkers of Magnesium in the Diet and for Nutritional Status.
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245 1 0 $a Assessing Biomarkers of Magnesium in the Diet and for Nutritional Status.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2021
300 $a 323 p.
500 $a Source: Dissertations Abstracts International, Volume: 83-02, Section: B.
500 $a Advisor: Gletsu Miller, Nana.
502 $a Thesis (Ph.D.)--Indiana University, 2021.
506 $a This item must not be sold to any third party vendors.
520 $a Objectives: To determine simple and accurate measures of dietary intake of magnesium (Mg) and Mg status as well as their reference ranges in healthy adult populations. To compare the reference range of healthy populations with the values for populations with diseases. To develop a protocol paper to compare the bioavailability of two dietary Mg supplements (MgCl2, MgO) in healthy adults as measured with ionized Mg (iMg+2) concentrations in whole blood, total Mg in urine, and serum Mg concentrations. Study 1 Methods: We searched OVID MEDLINE®, Cochrane Central Register of Controlled Trials, and EMBASE through 24 July 2020 to identify related articles. The reference range for our population-level study was estimated using a frequentist random-effects model. Study 2 Methods: Total dietary Mg intake obtained from 3-day food records was compared with iMg+2 and serum Mg concentrations from each of the three study visits. A linear mixed-effects model was fit with dietary Mg as the outcome variable, with fixed effects considered for iMg+2, serum Mg, treatment, and study visit. Age, gender, body mass index, and race were accounted for in the model. Study 3 Methods: We designed a double-blind, three-period crossover randomized controlled trial among healthy participants (n = 46) aged 18-65 years old. Study participants will be provided with 1) a placebo containing lemon juice and water, which will serve as the control; 2) magnesium oxide (NOW; NOW Foods, Bloomingdale, IL, USA, 300 mg elemental magnesium); and 3) magnesium chloride (Brand: Remag®; New Capstone Inc., Mooresville, NC, USA 300 mg elemental magnesium). Study 1 Results: Results from our healthy population data showed a reference range of 0.40-0.68 mmol/L for iMg+2. All of the ranges for the populations with diseases overlapped with our estimated reference range for iMg+2. We obtained a reference range of 0.72-1.0 mmol/L for serum Mg concentrations. Similarly, populations with diseases had measures that were within the reference range for serum Mg. Study 2 Results: No association was found between reported dietary Mg intake and iMg+2 (F = 0.18, p = 0.67). Similar results were found between dietary Mg intake and serum Mg (F = 3.02, p = 0.10). Conclusions: Our reference range captures population with disease ranges. This reference range may not be sensitive or specific for diagnosing Mg deficiency. We also found that iMg+2 may not be a measure of chronic Mg dietary intake. We expect that the study protocol will enable the evaluation of bioavailable Mg supplements using iMg+2. Our findings will support future research on magnesium deficiencies in the context of metabolic disease.
590 $a School code: 0093.
650 4 $a Epidemiology. $3 568544
650 4 $a Biostatistics. $3 1002712
650 4 $a Behavioral psychology. $3 2122788
650 4 $a Biomarkers. $3 2205735
650 4 $a Insulin resistance. $3 1016456
650 4 $a Kidneys. $3 2108687
650 4 $a Chronic illnesses. $3 3550688
653 $a Bioavailability
653 $a Biomarker
653 $a Dietary supplement
653 $a Ionized magnesium
653 $a Magnesium
653 $a Nutrition
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690 $a 0308
690 $a 0384
710 2 $a Indiana University. $b School of Public Health. $3 3169056
773 0 $t Dissertations Abstracts International $g 83-02B.
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791 $a Ph.D.
792 $a 2021
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28548047