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Self-Assembly of Short Peptide Derivatives.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Self-Assembly of Short Peptide Derivatives./
作者:	Lin, Tao.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:	195 p.
附註:	Source: Dissertations Abstracts International, Volume: 83-06, Section: B.
Contained By:	Dissertations Abstracts International83-06B.
標題:	Chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28845584
ISBN:	9798471104723

Self-Assembly of Short Peptide Derivatives.
Lin, Tao.

Self-Assembly of Short Peptide Derivatives. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 195 p.

Source: Dissertations Abstracts International, Volume: 83-06, Section: B.

Thesis (Ph.D.)--The Ohio State University, 2021.

This item must not be sold to any third party vendors.

The self-assembly of simple peptides and peptide derivatives are powerful method in developing new nanomaterials for tissue engineering, targeted drug delivery, optoelectronics, etc. Many of the self-assembly system comprise only one component and designing and controlling multicomponent self-assembly is challenging since not only force balance between individual components but also noncovalent interactions between different component should be included in the study. Here, we investigated self-assembly consist of peptide and protein and multicomponent self-assembly of different peptides. We synthesized a series of peptide derivatives AAC1-7 which contained amino acids with different charges and antioxidative moieties. The self-assembly of the peptide derivatives were investigated. Among the all the AACs, AAC2 displayed low cytotoxicity and the co-assembly of AAC2 and human insulin was studied. Further studies revealed that AAC2 itself had promising effect on controlling glucose homeostasis in vitro. Animal studies in type 1 diabetic mice revealed that AAC2 maintained glucose homeostasis as insulin without increasing adiposity. AAC2 also increased brain mass and anxiety-related behaviors in type 1 diabetic mice. Overall, AAC2 induced glucose uptake via a distinct mechanism that activated LepR/PKC?/GLUT1 axis and it could provide a novel strategy to treat diabetes and prevent complications of nervous and insulin-resistant tissues. We also investigated multicomponent assembly of two oppositely charged peptides. Positively charged peptide Fmoc-KK-BA (AAC7) and negatively charged peptide Fmoc-EK-MC (AAC4?) were able to individually self-assemble into nanotubes and nanofibers respectively. The self-assembly of both peptides were concentration dependent. As pre-assembled AAC7 and AAC4? were combined, electrostatic interactions between positively charge AAC7 nanotubes and negatively charged AAC4? nanofibers led to wrapping of nanofibers on the surface of nanotubes. In contrast, when AAC7 and AAC4? were combined in monomeric form, the co-assembly of the peptides resulted in nanofibers with width of 13 nm, which were distinctive compare to the mixture of pre-assembled peptides.

ISBN: 9798471104723Subjects--Topical Terms:

516420
Chemistry.
Subjects--Index Terms:

Self-assembly

Self-Assembly of Short Peptide Derivatives.
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245 1 0 $a Self-Assembly of Short Peptide Derivatives.
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500 $a Source: Dissertations Abstracts International, Volume: 83-06, Section: B.
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506 $a This item must not be sold to any third party vendors.
520 $a The self-assembly of simple peptides and peptide derivatives are powerful method in developing new nanomaterials for tissue engineering, targeted drug delivery, optoelectronics, etc. Many of the self-assembly system comprise only one component and designing and controlling multicomponent self-assembly is challenging since not only force balance between individual components but also noncovalent interactions between different component should be included in the study. Here, we investigated self-assembly consist of peptide and protein and multicomponent self-assembly of different peptides. We synthesized a series of peptide derivatives AAC1-7 which contained amino acids with different charges and antioxidative moieties. The self-assembly of the peptide derivatives were investigated. Among the all the AACs, AAC2 displayed low cytotoxicity and the co-assembly of AAC2 and human insulin was studied. Further studies revealed that AAC2 itself had promising effect on controlling glucose homeostasis in vitro. Animal studies in type 1 diabetic mice revealed that AAC2 maintained glucose homeostasis as insulin without increasing adiposity. AAC2 also increased brain mass and anxiety-related behaviors in type 1 diabetic mice. Overall, AAC2 induced glucose uptake via a distinct mechanism that activated LepR/PKC?/GLUT1 axis and it could provide a novel strategy to treat diabetes and prevent complications of nervous and insulin-resistant tissues. We also investigated multicomponent assembly of two oppositely charged peptides. Positively charged peptide Fmoc-KK-BA (AAC7) and negatively charged peptide Fmoc-EK-MC (AAC4?) were able to individually self-assemble into nanotubes and nanofibers respectively. The self-assembly of both peptides were concentration dependent. As pre-assembled AAC7 and AAC4? were combined, electrostatic interactions between positively charge AAC7 nanotubes and negatively charged AAC4? nanofibers led to wrapping of nanofibers on the surface of nanotubes. In contrast, when AAC7 and AAC4? were combined in monomeric form, the co-assembly of the peptides resulted in nanofibers with width of 13 nm, which were distinctive compare to the mixture of pre-assembled peptides.
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650 4 $a Chemistry. $3 516420
650 4 $a Nanoscience. $3 587832
653 $a Self-assembly
653 $a Short peptide derivatives
653 $a Nanomaterials
653 $a Glucose homeostasis
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773 0 $t Dissertations Abstracts International $g 83-06B.
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793 $a English
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