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The Relation between Hyperlipidemia, Hypertension, and Downstream Cognitive and Neuroanatomical Function.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Relation between Hyperlipidemia, Hypertension, and Downstream Cognitive and Neuroanatomical Function./
作者:	Wasserman, Victor J.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2022,
面頁冊數:	160 p.
附註:	Source: Dissertations Abstracts International, Volume: 82-07, Section: B.
Contained By:	Dissertations Abstracts International82-07B.
標題:	Clinical psychology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28261414
ISBN:	9798557032735

The Relation between Hyperlipidemia, Hypertension, and Downstream Cognitive and Neuroanatomical Function.
Wasserman, Victor J.

The Relation between Hyperlipidemia, Hypertension, and Downstream Cognitive and Neuroanatomical Function. - Ann Arbor : ProQuest Dissertations & Theses, 2022 - 160 p.

Source: Dissertations Abstracts International, Volume: 82-07, Section: B.

Thesis (Ph.D.)--Rowan University, 2022.

This item must not be sold to any third party vendors.

Objective: Cardiovascular risks (CVR) such as hypertension and hyperlipidemia play a critical role in the emergence of dementia syndromes. Medication to treat CVR may not obviate downstream risk for cognitive change. Methods: To examine the relation between history of treatment with medications to treat CVR and cognitive outcomes, participants were seen at time points ~7 years apart, completed neuropsychological evaluations, assessed for history of treatment with medication associated with hypertension and hyperlipidemia as indicators of CVR, and classified into 3 groups: Not Treated, Inconsistently Treated, and Consistently Treated. Regression models associating neuropsychological outcome measures of cognition and CVR were explored and refined within a "test dataset," and analyses were replicated using an independent "validation dataset."Result: Most outcome measures were not significant, including episodic memory and executive tests. A main effect was found for hypertension for the Similarities subtest and the Digit Symbol Test; participants with no hypertension treatment history obtained better scores compared to other groups. While some measures were sensitive to impairment, MRI parameters were not associated with CVR indicators.Conclusion: Between group differences on outcome measures of cognition were detectable in the presence of well-controlled blood pressure, indicating that downstream cognitive consequences persist in the presence of intervention for hypertension.

ISBN: 9798557032735Subjects--Topical Terms:

524863
Clinical psychology.
Subjects--Index Terms:

Alzheimer's disease

The Relation between Hyperlipidemia, Hypertension, and Downstream Cognitive and Neuroanatomical Function.
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