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Ultrasonic Locating and Tracking of Small Particles for Biomedical Applications.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Ultrasonic Locating and Tracking of Small Particles for Biomedical Applications./
作者:	Chen, Qiyang.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:	133 p.
附註:	Source: Dissertations Abstracts International, Volume: 83-06, Section: B.
Contained By:	Dissertations Abstracts International83-06B.
標題:	Histology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28845154
ISBN:	9798759921608

Ultrasonic Locating and Tracking of Small Particles for Biomedical Applications.
Chen, Qiyang.

Ultrasonic Locating and Tracking of Small Particles for Biomedical Applications. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 133 p.

Source: Dissertations Abstracts International, Volume: 83-06, Section: B.

Thesis (Ph.D.)--University of Pittsburgh, 2021.

This item must not be sold to any third party vendors.

This dissertation focuses on the development of two novel ultrasound technologies with the idea of tracking and locating small particles: 1) Ultrasound tracking of the acoustically actuated microswimmers, 2) Super-resolution ultrasound (SRU) imaging by locating the microbubbles.Artificial microswimmers that navigate in hard-to-reach spaces and microfluidic environments inside human bodies hold a great potential for various biomedical applications. For eventual translation of the microswimmer technology, a capability of tracking the microswimmers in 3-D through tissues is particularly required for reliable navigation. In this work, after first proposing and demonstrating the proof-of-concept of ultrasound tracking of the microswimmer in a 2-D setup in vitro, we built a 3-D ultrasound tracking system using two clinical ultrasound probes. A reliable performance for tracking the arbitrary 3-D motions of the newly designed 3-D microswimmers in real-time was demonstrated in vitro. The developed 3-D ultrasound tracking strategy could be a strong motivation and foundation for the future clinical translation of the novel microswimmer technology.SRU that can identify microvessels with unprecedented spatial resolution is promising for diagnosing the diseases associated with abnormal microvascular changes. One of the potential applications is to assess the changes in renal microvasculature during the progressive kidney disease. In this work, we applied the developed deconvolution-based SRU imaging on the mouse acute kidney injury (AKI) model to show the capability of SRU for noninvasive assessment of renal microvasculature changes during the progression from AKI to chronic kidney disease (CKD). v The technology was then adapted to a clinical curved linear array probe and evaluated on both healthy human subjects and CKD patients. We also applied the SRU technology for identifying the vasa vasorum near rabbit femoral arteries that is a key biomarker for atherosclerosis plaque development. Overall, the study demonstrates a great potential of SRU as a diagnostic tool for these diseases and would promote the eventual clinical translations.Future endeavors for integrating SRU locating technology with a reliable tracking capability of microparticles will provide a unique tool for various biomedical applications of the novel microdrones for diagnosis and drug delivery.

ISBN: 9798759921608Subjects--Topical Terms:

641250
Histology.

Ultrasonic Locating and Tracking of Small Particles for Biomedical Applications.
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