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DNA vaccine against HIV-1 Gag: From the bench to the field.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	DNA vaccine against HIV-1 Gag: From the bench to the field./
作者:	Qiu, Jian-Tai.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2001,
面頁冊數:	167 p.
附註:	Source: Dissertations Abstracts International, Volume: 63-01, Section: B.
Contained By:	Dissertations Abstracts International63-01B.
標題:	Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3006329
ISBN:	9780493156446

DNA vaccine against HIV-1 Gag: From the bench to the field.
Qiu, Jian-Tai.

DNA vaccine against HIV-1 Gag: From the bench to the field. - Ann Arbor : ProQuest Dissertations & Theses, 2001 - 167 p.

Source: Dissertations Abstracts International, Volume: 63-01, Section: B.

Thesis (Ph.D.)--The Johns Hopkins University, 2001.

This item must not be sold to any third party vendors.

We have summarized our efforts over the last several years to enhance the immunogenecity of HIV-1 Gag DNA vaccines. By destroying the inhibitory sequences in the coding region of HIV-1 Gag, we not only significantly increased the protein expression of HIV-1 in various cell types in a Rev-independent fashion, we have also enhanced both T helper and CTL responses in mice immunized with these novel DNA vaccines (Qiu et al., 1999). Subsequently, we have demonstrated that increasing the release of Gag from producer cells after DNA immunization could enhance both T helper and CTL responses (Qiu et al., 2000). We also showed that by targeting the secreted Gag antigen to antigen presentation cells through fusion with ligands of antigen presentation cells such as CTLA-4 (Qiu et al., 2001 submitted), CD40L, and MCP-3, we will be able to further enhance humoral or cellular immune responses. After 4 years of preparatory effort, our group just recently set up China's first HIV/AIDS cohort study based on 700 IV drug users in Guangxi Province. We have received grant support from the NIH to do the clinical trial in Guangxi Province. We are designing and implementing effective intervention/vaccination strategies targeted toward both injection drug use and high risk sexual behavior to reduce HIV-1 spread in China.

ISBN: 9780493156446Subjects--Topical Terms:

536250
Microbiology.
Subjects--Index Terms:

Cellular immune response

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