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The Calabar bean and its alkaloids =...

Robinson, Brian.

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The Calabar bean and its alkaloids = from magic, via miracle, to memory /

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Calabar bean and its alkaloids/ by Brian Robinson.
Reminder of title:	from magic, via miracle, to memory /
Author:	Robinson, Brian.
Published:	Dordrecht :Springer Netherlands : : 2023.,
Description:	xxvi, 267 p. :ill., digital ;24 cm.
[NT 15003449]:	Chronology -- Abbreviations -- Preface and acknowledgements -- 1. Introduction -- 2. l-Physostigmine (eserine) -- 3. l-Physovenine -- 4. l-Eseramine -- 5. l-N(8)-Norphysostigmine -- 6. l-Geneserine -- 7. 1H-, 13C- and 15N-Nuclear magnetic resonance spectra of the alkaloids of the Calabar bean -- 8. Other alkaloids of, as yet, unknown structures that have been isolated, or allegedly so, from the Calabar bean -- 9. Non-alkaloidal components of the Calabar bean -- 10. Biological activities of the alkaloids of the Calabar bean -- 11. Notes -- 12. References -- 13. Index.
Contained By:	Springer Nature eBook
Subject:	Calabar bean - Therapeutic use. -
Online resource:	https://doi.org/10.1007/978-94-024-1191-1
ISBN:	9789402411911

The Calabar bean and its alkaloids = from magic, via miracle, to memory /
Robinson, Brian.

The Calabar bean and its alkaloidsfrom magic, via miracle, to memory /[electronic resource] :by Brian Robinson. - Dordrecht :Springer Netherlands :2023. - xxvi, 267 p. :ill., digital ;24 cm.

Chronology -- Abbreviations -- Preface and acknowledgements -- 1. Introduction -- 2. l-Physostigmine (eserine) -- 3. l-Physovenine -- 4. l-Eseramine -- 5. l-N(8)-Norphysostigmine -- 6. l-Geneserine -- 7. 1H-, 13C- and 15N-Nuclear magnetic resonance spectra of the alkaloids of the Calabar bean -- 8. Other alkaloids of, as yet, unknown structures that have been isolated, or allegedly so, from the Calabar bean -- 9. Non-alkaloidal components of the Calabar bean -- 10. Biological activities of the alkaloids of the Calabar bean -- 11. Notes -- 12. References -- 13. Index.

Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery. Those in particular involving its major such component, l-physostigmine, have led to an understanding of some of the fundamental mechanisms occurring in physiology, pharmacology and biochemistry and, either actually or potentially (by providing a template and thereby acting as a "lead compound") have provided a useful treatment for a variety of neurological disorders associated with irregularities in cholinergic transmission in which augmentation of cholinergic activity has proved to be beneficial.

ISBN: 9789402411911

Standard No.: 10.1007/978-94-024-1191-1doiSubjects--Topical Terms:

3630148
Calabar bean
--Therapeutic use.

LC Class. No.: RS165.C16

Dewey Class. No.: 615.321

The Calabar bean and its alkaloids = from magic, via miracle, to memory /
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505 0 $a Chronology -- Abbreviations -- Preface and acknowledgements -- 1. Introduction -- 2. l-Physostigmine (eserine) -- 3. l-Physovenine -- 4. l-Eseramine -- 5. l-N(8)-Norphysostigmine -- 6. l-Geneserine -- 7. 1H-, 13C- and 15N-Nuclear magnetic resonance spectra of the alkaloids of the Calabar bean -- 8. Other alkaloids of, as yet, unknown structures that have been isolated, or allegedly so, from the Calabar bean -- 9. Non-alkaloidal components of the Calabar bean -- 10. Biological activities of the alkaloids of the Calabar bean -- 11. Notes -- 12. References -- 13. Index.
520 $a Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery. Those in particular involving its major such component, l-physostigmine, have led to an understanding of some of the fundamental mechanisms occurring in physiology, pharmacology and biochemistry and, either actually or potentially (by providing a template and thereby acting as a "lead compound") have provided a useful treatment for a variety of neurological disorders associated with irregularities in cholinergic transmission in which augmentation of cholinergic activity has proved to be beneficial.
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