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G protein-coupled receptors = immobi...

Zhao, Xinfeng.

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G protein-coupled receptors = immobilization and applications in drug discovery /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	G protein-coupled receptors/ by Xinfeng Zhao ... [et al.].
其他題名:	immobilization and applications in drug discovery /
其他作者:	Zhao, Xinfeng.
出版者:	Singapore :Springer Nature Singapore : : 2023.,
面頁冊數:	xii, 91 p. :ill., digital ;24 cm.
內容註:	G Protein-Coupled Receptors -- Purification of G Protein-Coupled Receptors -- Oriented Immobilization of G Protein-Coupled Receptors -- Key Biochemical Aspects of Drug-Target Interactions -- Immobilized GPCRs in Drug-Receptor Interaction Analysis -- Immobilized GPCRs in Compound Screening.
Contained By:	Springer Nature eBook
標題:	G proteins - Receptors. -
電子資源:	https://doi.org/10.1007/978-981-99-0078-7
ISBN:	9789819900787

G protein-coupled receptors = immobilization and applications in drug discovery /
G protein-coupled receptorsimmobilization and applications in drug discovery /[electronic resource] :by Xinfeng Zhao ... [et al.]. - Singapore :Springer Nature Singapore :2023. - xii, 91 p. :ill., digital ;24 cm. - SpringerBriefs in molecular science,2191-5415. - SpringerBriefs in molecular science..

G Protein-Coupled Receptors -- Purification of G Protein-Coupled Receptors -- Oriented Immobilization of G Protein-Coupled Receptors -- Key Biochemical Aspects of Drug-Target Interactions -- Immobilized GPCRs in Drug-Receptor Interaction Analysis -- Immobilized GPCRs in Compound Screening.

This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the "post-structural biology" era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition between enzymes and their substrates. With the perspective of protein-drug interactions, this book also reviews the applications of protein immobilization, with an emphasis on G protein-coupled receptors, in drug discovery and protein-ligand interaction analysis. In addition, the merits, opportunities and disadvantages are analyzed for different immobilization methods, and a perspective for future directions is presented. Given its scope, this book appeals to a broad readership, particularly researchers engaged in the field of analytical chemistry, bioconjugate chemistry, and chemical biology, and other related field, as well as teachers of relevant majors in colleges and universities.

ISBN: 9789819900787

Standard No.: 10.1007/978-981-99-0078-7doiSubjects--Topical Terms:

916557
G proteins
--Receptors.

LC Class. No.: QP552.G16 / Z43 2023

Dewey Class. No.: 572.6

G protein-coupled receptors = immobilization and applications in drug discovery /
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520 $a This book summarizes the progress made to functional immobilize G protein-coupled receptors (GPCRs) through site-specific or orientated recognition in both non-covalent and covalent manners. The last decade is the dawn of the "post-structural biology" era for G protein-coupled receptor research. As an emerging approach for state-of-the-art immobilization, this book discusses efforts to explore the elegance of naturally-occurring biochemical reactions by using their high specificity and robust reactivity in the complex system, such as site-specific conjugation by covalent recognition between enzymes and their substrates. With the perspective of protein-drug interactions, this book also reviews the applications of protein immobilization, with an emphasis on G protein-coupled receptors, in drug discovery and protein-ligand interaction analysis. In addition, the merits, opportunities and disadvantages are analyzed for different immobilization methods, and a perspective for future directions is presented. Given its scope, this book appeals to a broad readership, particularly researchers engaged in the field of analytical chemistry, bioconjugate chemistry, and chemical biology, and other related field, as well as teachers of relevant majors in colleges and universities.
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