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Modulation of Non-alcoholic Fatty Li...

Melo de Oliveira, Luma.

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Modulation of Non-alcoholic Fatty Liver Disease by Exercise.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Modulation of Non-alcoholic Fatty Liver Disease by Exercise./
Author:	Melo de Oliveira, Luma.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	180 p.
Notes:	Source: Dissertations Abstracts International, Volume: 83-01, Section: B.
Contained By:	Dissertations Abstracts International83-01B.
Subject:	Physiology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28542239
ISBN:	9798516919701

Modulation of Non-alcoholic Fatty Liver Disease by Exercise.
Melo de Oliveira, Luma.

Modulation of Non-alcoholic Fatty Liver Disease by Exercise. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 180 p.

Source: Dissertations Abstracts International, Volume: 83-01, Section: B.

Thesis (Ph.D.)--Indiana University, 2021.

This item must not be sold to any third party vendors.

Non-alcoholic fatty liver disease (NAFLD) affects up to one-third of the population in the western countries. Diet is the major cause related to NAFLD, however other factors including lack of exercise, genetic predisposition and metabolic sexual dimorphism could also be associated with the disease. Therefore, chronic endurance exercise and change in diet are therapeutic strategies in the treatment of NAFLD. Metabolic, cardiorespiratory, and endocrine pathways targeted by chronic endurance exercise have been widely identified in literature, however, the liver cellular and molecular pathways modified by exercise remain unresolved. On top of exercise, the role of diet has been well documented in the initiation and progression of NAFLD. Hepatocytes absorb fatty acids proportional to their concentration in the blood. An overabundance of saturated fats, sugars and cholesterol in the diet may lead to the steatosis in the liver, and so change of diet is essential. Given that, these studies show how the transcription of hepatic genes related to metabolic disease and steatosis can be modified by chronic exercise in both male and female mice, exploring the hepatic gene expression differences between female and male mice, in addition to exploring the potential of using exercise by itself and combined with change of diet as a treatment to NAFLD.

ISBN: 9798516919701Subjects--Topical Terms:

518431
Physiology.
Subjects--Index Terms:

Exercise

Modulation of Non-alcoholic Fatty Liver Disease by Exercise.
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245 1 0 $a Modulation of Non-alcoholic Fatty Liver Disease by Exercise.
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500 $a Source: Dissertations Abstracts International, Volume: 83-01, Section: B.
500 $a Advisor: Klaunig, James E.
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520 $a Non-alcoholic fatty liver disease (NAFLD) affects up to one-third of the population in the western countries. Diet is the major cause related to NAFLD, however other factors including lack of exercise, genetic predisposition and metabolic sexual dimorphism could also be associated with the disease. Therefore, chronic endurance exercise and change in diet are therapeutic strategies in the treatment of NAFLD. Metabolic, cardiorespiratory, and endocrine pathways targeted by chronic endurance exercise have been widely identified in literature, however, the liver cellular and molecular pathways modified by exercise remain unresolved. On top of exercise, the role of diet has been well documented in the initiation and progression of NAFLD. Hepatocytes absorb fatty acids proportional to their concentration in the blood. An overabundance of saturated fats, sugars and cholesterol in the diet may lead to the steatosis in the liver, and so change of diet is essential. Given that, these studies show how the transcription of hepatic genes related to metabolic disease and steatosis can be modified by chronic exercise in both male and female mice, exploring the hepatic gene expression differences between female and male mice, in addition to exploring the potential of using exercise by itself and combined with change of diet as a treatment to NAFLD.
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653 $a Mouse model
653 $a NAFLD
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