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Environmental and Dietary Determinan...

Sahasrabudhe, Neha R.

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Environmental and Dietary Determinants of Depressive Symptoms.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Environmental and Dietary Determinants of Depressive Symptoms./
作者:	Sahasrabudhe, Neha R.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:	130 p.
附註:	Source: Dissertations Abstracts International, Volume: 82-12, Section: B.
Contained By:	Dissertations Abstracts International82-12B.
標題:	Epidemiology. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28491025
ISBN:	9798505599686

Environmental and Dietary Determinants of Depressive Symptoms.
Sahasrabudhe, Neha R.

Environmental and Dietary Determinants of Depressive Symptoms. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 130 p.

Source: Dissertations Abstracts International, Volume: 82-12, Section: B.

Thesis (Sc.D.)--University of Massachusetts Lowell, 2021.

This item must not be sold to any third party vendors.

Depression is a multifaceted neuro-psychiatric disorder that is common yet complex in nature. It is one of the leading causes of disability that may add significant burden to the society globally. Health disparities related to depression have been observed, among the minority populations. Combinations of genetic, sociological, nutritional, occupational and environmental factors are thought to contribute to depression. Research examining potential environmental and dietary determinants of depression, especially among the minority populations such as Puerto Ricans, is limited.In Aims 1 and 2, we evaluated whether modifiable risk factors, including vitamin D status, assessed using serum 25-hydroxyvitamin D [25(OH)D] concentration, and adherence to the Mediterranean diet (MeD) are associated with self-reported depressive symptomatology, assessed with Center for Epidemiological Studies-Depression scale (CES-D) across three waves of follow-up in the cohort of Boston area Puerto Rican adults.In Aim 1, we did not observe any significant association between serum 25(OH)D and depressive symptomatology (CES-D score) in our baseline cross-sectional (β = -0.85, 95% CI: -2.80,1.10 for deficient vs. sufficient 25(OH)D, P trend = 0.59) as well as longitudinal analyses over 5 y (β = -0.41, 95% CI: -1.95,1.13 for deficient vs. sufficient 25(OH)D, P trend = 0.93). Sensitivity analyses restricting to vitamin D supplement non-users and in analyses conducted among participants with complete measures of baseline serum 25(OH)D and CES-D score at all three visits yielded consistent insignificant results.In Aim 2, We observed an association between MeD adherence and CES-D score at baseline (β= -1.9, 95% CI= -3.9, 0.02 for highest vs. lowest tertile, P trend= 0.045) and over 5 y of follow-up (β= -2.3, 95% CI= -3.4, -1.2 for highest vs lowest tertile, P trend < 0.0001). While CES-D scores were lower in those with higher MeD adherence over time, we did not observe a relationship between baseline MeD adherence and 5y CES-D trajectory (P int=0.93). Results were similar in analyses restricted to participants who did not report having clinically diagnosed diabetes at any visit, as well as in analyses conducted among participants with complete CES-D and MeD scores at all 3 visits. In Aim 3, we conducted a literature review to evaluate the relationship between Organophosphate exposure (OP), depression and gut microbiome. We highlighted gut bacterial alterations that have been more commonly and consistently identified across OP exposure and depression studies. We observed that genera Lactobacillus showed reduced abundance in response to OP exposure and was also observed to be lower among depressed patients, somewhat consistently across the studies included in this review. Several other genera and family alterations were also noted, however the literature on this topic is heterogenous.In summary, this dissertation focused on several potentially modifiable risk factors of depression, such as dietary intake and nutrients as well as exposure to OP and the gut microbiome. More studies are needed to develop preventive measures and more effective treatments for depression.

ISBN: 9798505599686Subjects--Topical Terms:

568544
Epidemiology.
Subjects--Index Terms:

Depressive symptomatology

Environmental and Dietary Determinants of Depressive Symptoms.
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