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Design of Functional Materials for Encapsulation and Controllable Re-Lease.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Design of Functional Materials for Encapsulation and Controllable Re-Lease./
作者:	Wu, Zhengwei.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:	96 p.
附註:	Source: Dissertations Abstracts International, Volume: 82-08, Section: B.
Contained By:	Dissertations Abstracts International82-08B.
標題:	Applied physics. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28157779
ISBN:	9798569981649

Design of Functional Materials for Encapsulation and Controllable Re-Lease.
Wu, Zhengwei.

Design of Functional Materials for Encapsulation and Controllable Re-Lease. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 96 p.

Source: Dissertations Abstracts International, Volume: 82-08, Section: B.

Thesis (Ph.D.)--University of Massachusetts Lowell, 2021.

This item must not be sold to any third party vendors.

Designing functional materials with triggered-release properties as effective carriers is an important challenge in the field of controlled release. These carriers can encapsulate and protect a variety of valuable and sensitive cargos that will be released when exposed to a specific stimulus, such as temperature, osmotic pressure, magnetic field, light, mechanical force, or pH; hence, they are widely used in numerous academic and industrial areas including pharmaceuticals, cosmetics, agriculture, biotech, waste treatment, and the petroleum, food, and chemical industries. In this thesis, microscale functional materials, including microgels and microcapsules, are designed to encapsulate various sensitive cargos, such as biocides, antibodies, and nonionic surfactants. These microparticles can be fabricated using either microfluidic technology or tip sonication methods. They can protect the encapsulated cargos for long-term storage and then controllably release these cargos for various applications. PEGDA-based microgels are fabricated by generating water-in-oil single emulsion droplets using a microfluidic device, followed by UV exposure to crosslink PEGDA. Biocides, which are used to prevent microbial contamination in the biodiesel industry, are added to the water phase with PEGDA and finally encapsulated within the microgels. The hydrophilic nature of hydrogels enables the rapid delivery of the encapsulated biocides to the water phase upon contact with water. The released biocides show higher antimicrobial efficacy than free biocides in both short-term and long-term experiments. In addition to biocides, this water-triggered release strategy can be used for encapsulating and releasing many other water-soluble functional cargos.Beyond biocides, surface-active materials are very useful in many areas, such as serving as surfactants for enhanced oil recovery, but they are difficult to encapsulate. Here, a new three-step bulk emulsification approach is developed for the high-throughput production of microcapsules to encapsulate nonionic surface-active material for controllable release. The effects of the emulsification power and time of the three-step bulk emulsification on the mean size and standard deviation of the droplets are investigated. The pH-responsive microcapsules can release the nonionic surface-active material upon contact with acid. Based on this strategy, other surface-active agents can be encapsulated to expedite a wide range of applications such as oil recovery and daily chemistry.In addition, sensitive biomolecules such as carbohydrates, proteins, lipids, and nucleic acids are essential for almost all life processes, and they are also used in a wide range of therapeutic, diagnostic, tissue regeneration, and bioprocess applications. However, their insufficient stability under storage and processing conditions greatly limits their applications in the biomedical field. In this thesis, inhomogeneous microcapsules are de-signed and fabricated using microfluidic technology to encapsulate enzymes into the aqueous core with an optimized buffer solution. The controlled release of enzymes is triggered by osmotic shock to introduce the rupture of inhomogeneous microcapsules. The results demonstrate that these microcapsules can be used for the long-term storage of enzymes, which can be controlled released through osmotic shock without impairing their biological activity. This study provides a new approach to designing effective carriers to encapsulate biomolecules and release them on-demand upon applying osmotic shock. In summary, my thesis demonstrates that through rationally designing microscale carriers, microgels or microcapsules can be fabricated to encapsulate various valuable cargos that can be protected and controllably released for different applications.

ISBN: 9798569981649Subjects--Topical Terms:

3343996
Applied physics.
Subjects--Index Terms:

Functional materials

Design of Functional Materials for Encapsulation and Controllable Re-Lease.
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500 $a Source: Dissertations Abstracts International, Volume: 82-08, Section: B.
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506 $a This item must not be sold to any third party vendors.
520 $a Designing functional materials with triggered-release properties as effective carriers is an important challenge in the field of controlled release. These carriers can encapsulate and protect a variety of valuable and sensitive cargos that will be released when exposed to a specific stimulus, such as temperature, osmotic pressure, magnetic field, light, mechanical force, or pH; hence, they are widely used in numerous academic and industrial areas including pharmaceuticals, cosmetics, agriculture, biotech, waste treatment, and the petroleum, food, and chemical industries. In this thesis, microscale functional materials, including microgels and microcapsules, are designed to encapsulate various sensitive cargos, such as biocides, antibodies, and nonionic surfactants. These microparticles can be fabricated using either microfluidic technology or tip sonication methods. They can protect the encapsulated cargos for long-term storage and then controllably release these cargos for various applications. PEGDA-based microgels are fabricated by generating water-in-oil single emulsion droplets using a microfluidic device, followed by UV exposure to crosslink PEGDA. Biocides, which are used to prevent microbial contamination in the biodiesel industry, are added to the water phase with PEGDA and finally encapsulated within the microgels. The hydrophilic nature of hydrogels enables the rapid delivery of the encapsulated biocides to the water phase upon contact with water. The released biocides show higher antimicrobial efficacy than free biocides in both short-term and long-term experiments. In addition to biocides, this water-triggered release strategy can be used for encapsulating and releasing many other water-soluble functional cargos.Beyond biocides, surface-active materials are very useful in many areas, such as serving as surfactants for enhanced oil recovery, but they are difficult to encapsulate. Here, a new three-step bulk emulsification approach is developed for the high-throughput production of microcapsules to encapsulate nonionic surface-active material for controllable release. The effects of the emulsification power and time of the three-step bulk emulsification on the mean size and standard deviation of the droplets are investigated. The pH-responsive microcapsules can release the nonionic surface-active material upon contact with acid. Based on this strategy, other surface-active agents can be encapsulated to expedite a wide range of applications such as oil recovery and daily chemistry.In addition, sensitive biomolecules such as carbohydrates, proteins, lipids, and nucleic acids are essential for almost all life processes, and they are also used in a wide range of therapeutic, diagnostic, tissue regeneration, and bioprocess applications. However, their insufficient stability under storage and processing conditions greatly limits their applications in the biomedical field. In this thesis, inhomogeneous microcapsules are de-signed and fabricated using microfluidic technology to encapsulate enzymes into the aqueous core with an optimized buffer solution. The controlled release of enzymes is triggered by osmotic shock to introduce the rupture of inhomogeneous microcapsules. The results demonstrate that these microcapsules can be used for the long-term storage of enzymes, which can be controlled released through osmotic shock without impairing their biological activity. This study provides a new approach to designing effective carriers to encapsulate biomolecules and release them on-demand upon applying osmotic shock. In summary, my thesis demonstrates that through rationally designing microscale carriers, microgels or microcapsules can be fabricated to encapsulate various valuable cargos that can be protected and controllably released for different applications.
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653 $a Surface-activated materials
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653 $a Proteins
653 $a Lipids
653 $a Nucleic acid
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