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A Secreted Signal from the Gut Inhib...

Lin-Moore, Alexander Tianma.

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A Secreted Signal from the Gut Inhibits Axon Regeneration in C. Elegans.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	A Secreted Signal from the Gut Inhibits Axon Regeneration in C. Elegans./
作者:	Lin-Moore, Alexander Tianma.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:	150 p.
附註:	Source: Dissertations Abstracts International, Volume: 83-02, Section: B.
Contained By:	Dissertations Abstracts International83-02B.
標題:	Genetics. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28321283
ISBN:	9798522998318

A Secreted Signal from the Gut Inhibits Axon Regeneration in C. Elegans.
Lin-Moore, Alexander Tianma.

A Secreted Signal from the Gut Inhibits Axon Regeneration in C. Elegans. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 150 p.

Source: Dissertations Abstracts International, Volume: 83-02, Section: B.

Thesis (Ph.D.)--Yale University, 2021.

This item must not be sold to any third party vendors.

Injured axons must regenerate to restore nervous system function, and regeneration is regulated in part by external factors from non-neuronal tissues. Many of these extrinsic factors act in the immediate cellular environment of the axon to promote or restrict regeneration, but the existence of long-distance signals regulating axon regeneration has not been clear. Here we show that the Rab GTPase rab-27 inhibits regeneration of GABAergic motor neurons in C. elegans through activity in the intestine. Re-expression of RAB-27, but not the closely related RAB-3, in the intestine of rab-27 mutant animals is sufficient to rescue normal regeneration. Several additional components of an intestinal neuropeptide secretion pathway also inhibit axon regeneration, including NPDC1/cab-1, SNAP25/aex-4, and KPC3/aex-5. Together these data indicate that RAB-27-dependent neuropeptide secretion from the intestine inhibits axon regeneration, and point to distal tissues as potent extrinsic regulators of regeneration.

ISBN: 9798522998318Subjects--Topical Terms:

530508
Genetics.
Subjects--Index Terms:

Axon regeneration

A Secreted Signal from the Gut Inhibits Axon Regeneration in C. Elegans.
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520 $a Injured axons must regenerate to restore nervous system function, and regeneration is regulated in part by external factors from non-neuronal tissues. Many of these extrinsic factors act in the immediate cellular environment of the axon to promote or restrict regeneration, but the existence of long-distance signals regulating axon regeneration has not been clear. Here we show that the Rab GTPase rab-27 inhibits regeneration of GABAergic motor neurons in C. elegans through activity in the intestine. Re-expression of RAB-27, but not the closely related RAB-3, in the intestine of rab-27 mutant animals is sufficient to rescue normal regeneration. Several additional components of an intestinal neuropeptide secretion pathway also inhibit axon regeneration, including NPDC1/cab-1, SNAP25/aex-4, and KPC3/aex-5. Together these data indicate that RAB-27-dependent neuropeptide secretion from the intestine inhibits axon regeneration, and point to distal tissues as potent extrinsic regulators of regeneration.
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