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Zoonotic Malaria in Southeast Asian ...

Zhang, Xinjun.

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Zoonotic Malaria in Southeast Asian Macaques.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Zoonotic Malaria in Southeast Asian Macaques./
作者:	Zhang, Xinjun.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
面頁冊數:	123 p.
附註:	Source: Dissertations Abstracts International, Volume: 79-10, Section: A.
Contained By:	Dissertations Abstracts International79-10A.
標題:	Physical anthropology. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10681287
ISBN:	9780355763959

Zoonotic Malaria in Southeast Asian Macaques.
Zhang, Xinjun.

Zoonotic Malaria in Southeast Asian Macaques. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 123 p.

Source: Dissertations Abstracts International, Volume: 79-10, Section: A.

Thesis (Ph.D.)--University of California, Davis, 2017.

This item must not be sold to any third party vendors.

This dissertation project aims to characterize the geographic distribution of malarial parasites, including two zoonotic parasites Plasmodium knowlesi and Plasmodium cynomolgi, in Southeast Asia in their natural hosts cynomolgus/long-tailed macaques ( Macaca fascicularis). Further investigation focuses on demographic history factors that may influence the prevalence and susceptibility differences of zoonotic malaria in regional long-tailed macaque populations, especially the admixture history with rhesus macaques (Macaca mulatta), under the purpose of characterizing the suitability of macaque captive colonies as biomedical research models. This project consists of three main parts. 1) the screening of M. fascicularis DNA samples from different regional populations across Southeast Asia in search for prevalence of malarial parasites infections. 2) the ancestry and admixture analysis of M. fascicularis from Chinese breeding farms, and the investigation of relationship between rhesus admixture amount in M. fascicularis and infection rate. 3) population genetics characterization of a captive colony of another natural hosts of P. knowlesi and P. cynomolgi, Southern pig-tailed macaques (Macaca nemestrina). In additional, the sequence of parasite DNA obtained from M. fascicularis samples are subject to a preliminary investigation of phylogenetic history and co-evolutionary history of malarial parasite and their macaque host populations. P. knowlesi and P. cynomolgi are relative newly confirmed zoonotic malaria that are naturally transmissible between human and non-human primates, which is opposite of previous widely accepted knowledge of Plasmodium parasites being highly host-specific. A careful examination and comparison of distribution and infection nature of the parasites in their macaque natural host groups would enable public health organizations in related area to target active prevention acts in human population under potential threat of infection. Knowing the association between susceptibility and admixture of different macaque species also sheds light on future identification of vital genes or genomic regions in human and non-human primates, which may reveal yet-to-be-discovered malarial adaptations, and further assist personalized and targeted treatment of zoonotic malaria.

ISBN: 9780355763959Subjects--Topical Terms:

518358
Physical anthropology.
Subjects--Index Terms:

Malaria

Zoonotic Malaria in Southeast Asian Macaques.
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520 $a This dissertation project aims to characterize the geographic distribution of malarial parasites, including two zoonotic parasites Plasmodium knowlesi and Plasmodium cynomolgi, in Southeast Asia in their natural hosts cynomolgus/long-tailed macaques ( Macaca fascicularis). Further investigation focuses on demographic history factors that may influence the prevalence and susceptibility differences of zoonotic malaria in regional long-tailed macaque populations, especially the admixture history with rhesus macaques (Macaca mulatta), under the purpose of characterizing the suitability of macaque captive colonies as biomedical research models. This project consists of three main parts. 1) the screening of M. fascicularis DNA samples from different regional populations across Southeast Asia in search for prevalence of malarial parasites infections. 2) the ancestry and admixture analysis of M. fascicularis from Chinese breeding farms, and the investigation of relationship between rhesus admixture amount in M. fascicularis and infection rate. 3) population genetics characterization of a captive colony of another natural hosts of P. knowlesi and P. cynomolgi, Southern pig-tailed macaques (Macaca nemestrina). In additional, the sequence of parasite DNA obtained from M. fascicularis samples are subject to a preliminary investigation of phylogenetic history and co-evolutionary history of malarial parasite and their macaque host populations. P. knowlesi and P. cynomolgi are relative newly confirmed zoonotic malaria that are naturally transmissible between human and non-human primates, which is opposite of previous widely accepted knowledge of Plasmodium parasites being highly host-specific. A careful examination and comparison of distribution and infection nature of the parasites in their macaque natural host groups would enable public health organizations in related area to target active prevention acts in human population under potential threat of infection. Knowing the association between susceptibility and admixture of different macaque species also sheds light on future identification of vital genes or genomic regions in human and non-human primates, which may reveal yet-to-be-discovered malarial adaptations, and further assist personalized and targeted treatment of zoonotic malaria.
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