東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Using Genetics to Assess Population ...

Viricel, Amelia.

FindBook

Google Book

Amazon

博客來

Using Genetics to Assess Population Structure in Three Cetacean Species and to Investigate the Etiology of Cardiomyopathy in Kogia breviceps.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Using Genetics to Assess Population Structure in Three Cetacean Species and to Investigate the Etiology of Cardiomyopathy in Kogia breviceps./
作者:	Viricel, Amelia.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2012,
面頁冊數:	263 p.
附註:	Source: Dissertations Abstracts International, Volume: 74-08, Section: B.
Contained By:	Dissertations Abstracts International74-08B.
標題:	Genetics. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3548595
ISBN:	9781267841568

Using Genetics to Assess Population Structure in Three Cetacean Species and to Investigate the Etiology of Cardiomyopathy in Kogia breviceps.
Viricel, Amelia.

Using Genetics to Assess Population Structure in Three Cetacean Species and to Investigate the Etiology of Cardiomyopathy in Kogia breviceps. - Ann Arbor : ProQuest Dissertations & Theses, 2012 - 263 p.

Source: Dissertations Abstracts International, Volume: 74-08, Section: B.

Thesis (Ph.D.)--University of Louisiana at Lafayette, 2012.

This item must not be sold to any third party vendors.

As top predators, marine mammals have an important role in marine food webs and are good indicators of ecosystem health. Therefore, marine mammals can be considered sentinel species for marine ecosystems, and monitoring their populations is of primary importance for marine conservation. In this context, I investigated population structure in three cetacean species, in the western North Atlantic and Gulf of Mexico: the Atlantic spotted dolphin ( Stenella frontalis) and the pygmy and dwarf sperm whales ( Kogia breviceps and K. sima). Population structure was assessed using two types of genetic markers, i.e., microsatellites and mitochondrial control region sequences. Population subdivision in Kogia species could be contrasted, as significant genetic differentiation was detected among three regions for K. breviceps, while no subdivision was identified in K. sima. In S. frontalis, genetic analyses revealed hierarchical structure, with a first level of divergence corresponding to the two known morphotypes, and multiple populations within the morphotype inhabiting continental shelf waters. Moreover, genetic analyses revealed the presence of putative hybrids between S. frontalis and the other species of spotted dolphin, S. attenuata. Further analyses of the hybrid ancestry of these individuals suggested that hybridization between S. frontalis and S. attenuata results in fertile, viable offspring and that hybridization mainly occurs between S. attenuata and the offshore morphotype of S. frontalis. Another important aspect in the conservation of these taxa is monitoring their population health and the causes of mortality. I used molecular data to investigate a potential genetic basis for a heart disease (cardiomyopathy) highly prevalent in stranded K. breviceps individuals. Exons from two candidate genes coding for sarcomeric proteins, which are involved in contraction of the heart muscle, were screened for mutations in K. breviceps individuals between a control group (no symptoms) and an affected group. Mutation screening revealed 11 nonsynonymous substitutions that were predicted to have a detrimental effect on protein function. My work will have direct applications in the conservation of these three cetacean species, as it provides baselines for the monitoring of their populations through stock delineation and characterization of an important source of mortality.

ISBN: 9781267841568Subjects--Topical Terms:

530508
Genetics.
Subjects--Index Terms:

Cardiomyopathy

Using Genetics to Assess Population Structure in Three Cetacean Species and to Investigate the Etiology of Cardiomyopathy in Kogia breviceps.
LDR:03790nmm a2200421 4500 001 2280999
005 20210910100054.5
008 220723s2012 ||||||||||||||||| ||eng d
020 $a 9781267841568
035 $a (MiAaPQ)AAI3548595
035 $a (MiAaPQ)louisiana:10034
035 $a AAI3548595
040 $a MiAaPQ $c MiAaPQ
100 1 $a Viricel, Amelia. $3 3559578
245 1 0 $a Using Genetics to Assess Population Structure in Three Cetacean Species and to Investigate the Etiology of Cardiomyopathy in Kogia breviceps.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2012
300 $a 263 p.
500 $a Source: Dissertations Abstracts International, Volume: 74-08, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Rosel, Patricia E.
502 $a Thesis (Ph.D.)--University of Louisiana at Lafayette, 2012.
506 $a This item must not be sold to any third party vendors.
520 $a As top predators, marine mammals have an important role in marine food webs and are good indicators of ecosystem health. Therefore, marine mammals can be considered sentinel species for marine ecosystems, and monitoring their populations is of primary importance for marine conservation. In this context, I investigated population structure in three cetacean species, in the western North Atlantic and Gulf of Mexico: the Atlantic spotted dolphin ( Stenella frontalis) and the pygmy and dwarf sperm whales ( Kogia breviceps and K. sima). Population structure was assessed using two types of genetic markers, i.e., microsatellites and mitochondrial control region sequences. Population subdivision in Kogia species could be contrasted, as significant genetic differentiation was detected among three regions for K. breviceps, while no subdivision was identified in K. sima. In S. frontalis, genetic analyses revealed hierarchical structure, with a first level of divergence corresponding to the two known morphotypes, and multiple populations within the morphotype inhabiting continental shelf waters. Moreover, genetic analyses revealed the presence of putative hybrids between S. frontalis and the other species of spotted dolphin, S. attenuata. Further analyses of the hybrid ancestry of these individuals suggested that hybridization between S. frontalis and S. attenuata results in fertile, viable offspring and that hybridization mainly occurs between S. attenuata and the offshore morphotype of S. frontalis. Another important aspect in the conservation of these taxa is monitoring their population health and the causes of mortality. I used molecular data to investigate a potential genetic basis for a heart disease (cardiomyopathy) highly prevalent in stranded K. breviceps individuals. Exons from two candidate genes coding for sarcomeric proteins, which are involved in contraction of the heart muscle, were screened for mutations in K. breviceps individuals between a control group (no symptoms) and an affected group. Mutation screening revealed 11 nonsynonymous substitutions that were predicted to have a detrimental effect on protein function. My work will have direct applications in the conservation of these three cetacean species, as it provides baselines for the monitoring of their populations through stock delineation and characterization of an important source of mortality.
590 $a School code: 1363.
650 4 $a Genetics. $3 530508
650 4 $a Conservation. $3 738625
650 4 $a Evolution and Development. $3 3422373
650 4 $a Biological oceanography. $3 2122748
653 $a Cardiomyopathy
653 $a Cetaceans
653 $a Hybridization
653 $a Population genetics
653 $a Population stocks
653 $a Population structure
690 $a 0369
690 $a 0408
690 $a 0412
690 $a 0416
710 2 $a University of Louisiana at Lafayette. $b Environmental and Evolutionary Biology. $3 3559579
773 0 $t Dissertations Abstracts International $g 74-08B.
790 $a 1363
791 $a Ph.D.
792 $a 2012
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3548595