語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Molecular Interactions Between Lumin...
~
Williams-Harris, Denise N.
FindBook
Google Book
Amazon
博客來
Molecular Interactions Between Luminescent Quantum Dots and Bacteria.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Molecular Interactions Between Luminescent Quantum Dots and Bacteria./
作者:
Williams-Harris, Denise N.
出版者:
Ann Arbor : ProQuest Dissertations & Theses, : 2020,
面頁冊數:
186 p.
附註:
Source: Dissertations Abstracts International, Volume: 82-05, Section: B.
Contained By:
Dissertations Abstracts International82-05B.
標題:
Cellular biology. -
電子資源:
https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28030462
ISBN:
9798691213137
Molecular Interactions Between Luminescent Quantum Dots and Bacteria.
Williams-Harris, Denise N.
Molecular Interactions Between Luminescent Quantum Dots and Bacteria.
- Ann Arbor : ProQuest Dissertations & Theses, 2020 - 186 p.
Source: Dissertations Abstracts International, Volume: 82-05, Section: B.
Thesis (Ph.D.)--University of Maryland, Baltimore County, 2020.
This item must not be sold to any third party vendors.
Luminescent semiconductor quantum dots (QDs) are continuously incorporated into bioassay, imaging, and treatment technologies. Cadmium-based QDs are commonly used in these technologies because of their superior optical properties-within the visible to near infrared wavelengths of light-compared to QDs made of other materials. However, concerns about cadmium toxicity have led to the increased use of protective coatings around cadmium-based QDs and to the development of QDs composed of more benign materials. The varying methods used to attain these QDs produce them with inherently different materials and structures. Additionally, QDs have varying homogeneous or heterogeneous surface chemistries. The QD surface may be either organic or aqueous-miscible; neutrally, positively, or negatively charged; and comprised of either short ligands, bulky biomolecules, or long polymeric chains. The different QD materials, structures, and surface chemistries impact whether QDs will associate with cells, and dictate what other interactions may occur after association. Our studies aim to concurrently investigate the impact that varying QDs' compositions have on their interactions with human and environmental health models in the context of antibacterial research. This context is important since there is currently a rise in the development of QD-based antibacterial treatments, which harness the inherent cytotoxic activity of QDs and steers it towards the rising onset of multidrug-resistant bacteria. Thus, this dissertation investigates the interactions of QDs with model liposomes, bacterial cells, and human red blood cells. We specifically compared the interactions of 1) CdSe core to ZnSe core QDs, 2) core QDs to ZnS-shelled QDs, 3) QDs with negatively charged ligand terminations to positively charged ligand terminations, and 4) core QDs of varying amine content surface coverage with these models. Various techniques-such as absorbance, emission, mass spectrometry, microscopy, dynamic light scattering, zeta potential, and FRET measurements-were used to characterize the QDs' compositions and their interactions with the biological models. These studies have increased our mechanistic understanding of the interactions between QDs and cells, how to control these interactions, and how to design future QD technologies to have intended interactions with targeted organisms while maintaining minimal impact on organisms which are essential to human and environmental health.
ISBN: 9798691213137Subjects--Topical Terms:
3172791
Cellular biology.
Subjects--Index Terms:
Antibacterials
Molecular Interactions Between Luminescent Quantum Dots and Bacteria.
LDR
:04079nmm a2200541 4500
001
2279731
005
20210823083429.5
008
220723s2020 ||||||||||||||||| ||eng d
020
$a
9798691213137
035
$a
(MiAaPQ)AAI28030462
035
$a
AAI28030462
040
$a
MiAaPQ
$c
MiAaPQ
100
1
$a
Williams-Harris, Denise N.
$3
3558205
245
1 0
$a
Molecular Interactions Between Luminescent Quantum Dots and Bacteria.
260
1
$a
Ann Arbor :
$b
ProQuest Dissertations & Theses,
$c
2020
300
$a
186 p.
500
$a
Source: Dissertations Abstracts International, Volume: 82-05, Section: B.
500
$a
Advisor: Rosenzweig, Zeev.
502
$a
Thesis (Ph.D.)--University of Maryland, Baltimore County, 2020.
506
$a
This item must not be sold to any third party vendors.
520
$a
Luminescent semiconductor quantum dots (QDs) are continuously incorporated into bioassay, imaging, and treatment technologies. Cadmium-based QDs are commonly used in these technologies because of their superior optical properties-within the visible to near infrared wavelengths of light-compared to QDs made of other materials. However, concerns about cadmium toxicity have led to the increased use of protective coatings around cadmium-based QDs and to the development of QDs composed of more benign materials. The varying methods used to attain these QDs produce them with inherently different materials and structures. Additionally, QDs have varying homogeneous or heterogeneous surface chemistries. The QD surface may be either organic or aqueous-miscible; neutrally, positively, or negatively charged; and comprised of either short ligands, bulky biomolecules, or long polymeric chains. The different QD materials, structures, and surface chemistries impact whether QDs will associate with cells, and dictate what other interactions may occur after association. Our studies aim to concurrently investigate the impact that varying QDs' compositions have on their interactions with human and environmental health models in the context of antibacterial research. This context is important since there is currently a rise in the development of QD-based antibacterial treatments, which harness the inherent cytotoxic activity of QDs and steers it towards the rising onset of multidrug-resistant bacteria. Thus, this dissertation investigates the interactions of QDs with model liposomes, bacterial cells, and human red blood cells. We specifically compared the interactions of 1) CdSe core to ZnSe core QDs, 2) core QDs to ZnS-shelled QDs, 3) QDs with negatively charged ligand terminations to positively charged ligand terminations, and 4) core QDs of varying amine content surface coverage with these models. Various techniques-such as absorbance, emission, mass spectrometry, microscopy, dynamic light scattering, zeta potential, and FRET measurements-were used to characterize the QDs' compositions and their interactions with the biological models. These studies have increased our mechanistic understanding of the interactions between QDs and cells, how to control these interactions, and how to design future QD technologies to have intended interactions with targeted organisms while maintaining minimal impact on organisms which are essential to human and environmental health.
590
$a
School code: 0434.
650
4
$a
Cellular biology.
$3
3172791
650
4
$a
Materials science.
$3
543314
650
4
$a
Quantum physics.
$3
726746
650
4
$a
Biochemistry.
$3
518028
650
4
$a
Nanoscience.
$3
587832
650
4
$a
Pharmacology.
$3
634543
650
4
$a
Health sciences.
$3
3168359
650
4
$a
Optics.
$3
517925
653
$a
Antibacterials
653
$a
Bacteria
653
$a
Human health
653
$a
Liposomes
653
$a
Nanomaterials
653
$a
Quantum Dots
653
$a
Semiconductor
653
$a
Treatment technologies
653
$a
Infrared wavelengths of light
653
$a
Benign materials
653
$a
Antibacterial research
653
$a
Multidrug-resistant bacteria
653
$a
Human red blood cells
653
$a
Ligand terminations
690
$a
0565
690
$a
0599
690
$a
0752
690
$a
0566
690
$a
0379
690
$a
0794
690
$a
0487
690
$a
0419
710
2
$a
University of Maryland, Baltimore County.
$b
Chemistry.
$3
1264605
773
0
$t
Dissertations Abstracts International
$g
82-05B.
790
$a
0434
791
$a
Ph.D.
792
$a
2020
793
$a
English
856
4 0
$u
https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28030462
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9431464
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入