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Synthesis and Characterization of Po...

Hardin, Nathaniel Zachary.

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Synthesis and Characterization of Polymers, and Development of Polymer Based Lipid-Nanodiscs.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Synthesis and Characterization of Polymers, and Development of Polymer Based Lipid-Nanodiscs./
作者:	Hardin, Nathaniel Zachary.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
面頁冊數:	116 p.
附註:	Source: Dissertations Abstracts International, Volume: 81-11, Section: B.
Contained By:	Dissertations Abstracts International81-11B.
標題:	Chemistry. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28006484
ISBN:	9798643184072

Synthesis and Characterization of Polymers, and Development of Polymer Based Lipid-Nanodiscs.
Hardin, Nathaniel Zachary.

Synthesis and Characterization of Polymers, and Development of Polymer Based Lipid-Nanodiscs. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 116 p.

Source: Dissertations Abstracts International, Volume: 81-11, Section: B.

Thesis (Ph.D.)--University of Michigan, 2020.

This item must not be sold to any third party vendors.

There is substantial interest in the development of membrane mimetics for use in membrane protein (MP) studies. MPs require a native like membrane environment for the study of their structure, dynamics, and function. Polymers that assemble into lipid nanodiscs with membranes have been shown to be useful in forming a native like membrane mimetic. This is demonstrated by their ability to self-assemble into a native like membrane environment, and their ability to extract MPs without the use of detergents. To achieve the formation of polymer-lipid nanodiscs the polymer with the proper characteristics must be used. In this talk I will focus on our research in the development of differing polymers with various hydrophobic and hydrophilic modifications. We showed the relationship between the hydrophilic moiety and the nanodiscs solution properties. This functionalization widened the application of polymer-nanodiscs to a great range of biologically relevant conditions. We further demonstrated the effect of differing hydrophobic moieties on nanodiscs stability. Finally, we formulated a polymer-lipid nanodiscs system with improved NMR applications with the potential to reduce NMR experiment times.

ISBN: 9798643184072Subjects--Topical Terms:

516420
Chemistry.
Subjects--Index Terms:

Polymers

Synthesis and Characterization of Polymers, and Development of Polymer Based Lipid-Nanodiscs.
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300 $a 116 p.
500 $a Source: Dissertations Abstracts International, Volume: 81-11, Section: B.
500 $a Advisor: Ramamoorthy, Ayyalusamy.
502 $a Thesis (Ph.D.)--University of Michigan, 2020.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a There is substantial interest in the development of membrane mimetics for use in membrane protein (MP) studies. MPs require a native like membrane environment for the study of their structure, dynamics, and function. Polymers that assemble into lipid nanodiscs with membranes have been shown to be useful in forming a native like membrane mimetic. This is demonstrated by their ability to self-assemble into a native like membrane environment, and their ability to extract MPs without the use of detergents. To achieve the formation of polymer-lipid nanodiscs the polymer with the proper characteristics must be used. In this talk I will focus on our research in the development of differing polymers with various hydrophobic and hydrophilic modifications. We showed the relationship between the hydrophilic moiety and the nanodiscs solution properties. This functionalization widened the application of polymer-nanodiscs to a great range of biologically relevant conditions. We further demonstrated the effect of differing hydrophobic moieties on nanodiscs stability. Finally, we formulated a polymer-lipid nanodiscs system with improved NMR applications with the potential to reduce NMR experiment times.
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650 4 $a Biochemistry. $3 518028
650 4 $a Nanoscience. $3 587832
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653 $a Nanodiscs
653 $a NMR
653 $a Biomaterial
653 $a Nanomaterials
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