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The Role of Exercise Intensity in Ce...

Terry, Ciara.

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The Role of Exercise Intensity in Cell Signaling: Is There a Repeated-Bout Effect?

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Role of Exercise Intensity in Cell Signaling: Is There a Repeated-Bout Effect?/
作者:	Terry, Ciara.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
面頁冊數:	76 p.
附註:	Source: Masters Abstracts International, Volume: 82-06.
Contained By:	Masters Abstracts International82-06.
標題:	Cellular biology. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28256994
ISBN:	9798557009041

The Role of Exercise Intensity in Cell Signaling: Is There a Repeated-Bout Effect?
Terry, Ciara.

The Role of Exercise Intensity in Cell Signaling: Is There a Repeated-Bout Effect? - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 76 p.

Source: Masters Abstracts International, Volume: 82-06.

Thesis (M.S.)--Northern Arizona University, 2020.

This item must not be sold to any third party vendors.

Acute exercise elicits a temporary change in redox balance resulting in activation of antioxidant related gene expression and enzymes. We have previously shown in men that the type of acute exercise stimulus, constant workload (CW) vs. high intensity interval protocol (HIIP) results in different redox responses despite no differences in mean VO2. The present study tested whether these results translate to women. In addition, we asked whether the responses are amplified through a repeated bout effect, by comparing the responses after a single bout to those after three bouts. It was hypothesized that HIIP would render greater cell signaling response compared to CW and that differences would be amplified after three sessions. Healthy women ages 30-45y participated in this study in a randomized, cross-over design with a 2-week washout period between trials. Each participant completed a VO2max on a cycle ergometer to establish the workload for the exercise trials. Subjects were randomized to complete either CW or HIIP sessions first. Each trial occurred every other day for 5 days. A second VO2max was performed prior to the second trial to ascertain that VO2 max had not changed from baseline. CW consisted of 30-min of cycling at 70% VO2max. HIIP consisted of a 9-min ramp-up, 7 intervals of 1-min "all out" intervals at 90-100% VO2max followed by 2-min recovery for a total of 30-min of cycling. Blood draws were taken pre-, and 10- 30-, and 60-min post exercise during the first and third exercise session of each trial. Cell signaling was measured by nuclear localization of Nrf2 as well as protein abundance of GCLC, GSR, GPx1, and Trx2 in PBMCs. GSR enzyme activity was measured in erythrocyte lysate. Perception of well-being questionnaires were scored to determine the psychological effect of exercise intensity. Seven women completed the study which had to be halted due to Covid-19. The average intensity of the CW trial was 71% and the average intensity of the HIIP intervals was 95% VO2max. VO2max improved significantly after the first exercise protocol, irrespective of intensity (p = 0.017). Protein expression was not significantly different between the exercise sessions. Basal levels of protein were increased to a large effect during the third trial of both protocols. GSR enzyme activity was not significantly different between CW and HIIP, or the first and third sessions of either protocol. These data suggest that changes in protein expression are amplified by a repeated bout effect and that VO2max can be significantly improved after just 3 exercise sessions regardless of intensity. These data also suggest that cell signaling responses are not significantly impacted by exercise intensity.

ISBN: 9798557009041Subjects--Topical Terms:

3172791
Cellular biology.
Subjects--Index Terms:

Exercise

The Role of Exercise Intensity in Cell Signaling: Is There a Repeated-Bout Effect?
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