東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

The Effects of Obesity, Chronic Stre...

Tice, Abigail.

FindBook

Google Book

Amazon

博客來

The Effects of Obesity, Chronic Stress, and Exercise on Pancreatic Health.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Effects of Obesity, Chronic Stress, and Exercise on Pancreatic Health./
作者:	Tice, Abigail.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
面頁冊數:	91 p.
附註:	Source: Masters Abstracts International, Volume: 81-04.
Contained By:	Masters Abstracts International81-04.
標題:	Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27527115
ISBN:	9781085643948

The Effects of Obesity, Chronic Stress, and Exercise on Pancreatic Health.
Tice, Abigail.

The Effects of Obesity, Chronic Stress, and Exercise on Pancreatic Health. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 91 p.

Source: Masters Abstracts International, Volume: 81-04.

Thesis (M.S.)--West Virginia University, 2019.

This item must not be sold to any third party vendors.

Obesity is concomitant with hyperglycemic conditions, increased proinflammatory cytokines, and increased oxidative stress. Under hyperglycemia, thioredoxin interacting protein (TXNIP) is increased and causes increased oxidative stress and pancreatic β-cell apoptosis. Chronic stress is associated with increased glucocorticoid levels and a proinflammatory environment. The purpose of this study was to examine the effects of obesity, chronic stress, and exercise on pancreatic health.Lean Zucker Rats (LZRs) and Obese Zucker Rats (OZRs) were randomly assigned to four groups: 1) sedentary controls (C: n=8 per); 2) unpredictable chronic mild stress (UCMS) (S: n=8); 3) exercise (E: n=8); and 4) combined UCMS and exercise (ExS: n=8). Exercise rats underwent 8 weeks of treadmill running for 60 minutes. Stress rats were subjected to UCMS that included cage tilt, no bedding, damp bedding, bath, social stress, and altered light-dark cycles for 8 hours a day, 5 days a week for 8 weeks. Pancreas tissue was obtained from rats around 20 weeks of age. Total pancreatic TXNIP protein was quantified, including total pancreatic cytokine expression for IL-1β, TNF-α, IL-4, and IL-10. Using immunohistochemistry, β-cell and α-cell counting, islet area measurements, and β-cell to α-cell ratio were examined. TUNEL staining, to determine apoptosis, was examined in pancreatic lysates.OZRs had higher insulin, glucose, and body mass compared to LZRs, as wells as higher β-cell and α-cell number and islet area (p<0.05).In a model of obesity and metabolic syndrome, the pancreas appeared to be stimulated to grow as indicated by greater numbers of β- and α-cells and larger islets even in the presence of slightly higher pancreatic TXNIP and TNF-α. Obesity resulted in an increased level of inflammation and reduced antioxidant potential within the pancreas as indicated by significantly higher TXNIP, IL-1β, and TNF-α. Eight weeks of treadmill running reversed this effect. Exercise training was also able to reduced TXNIP within the pancreas as a result of stress.

ISBN: 9781085643948Subjects--Topical Terms:

518431
Physiology.

The Effects of Obesity, Chronic Stress, and Exercise on Pancreatic Health.
LDR:03104nmm a2200313 4500 001 2273912
005 20201109125347.5
008 220629s2019 ||||||||||||||||| ||eng d
020 $a 9781085643948
035 $a (MiAaPQ)AAI27527115
035 $a (MiAaPQ)WVirginia5143
035 $a AAI27527115
040 $a MiAaPQ $c MiAaPQ
100 1 $a Tice, Abigail. $3 3551370
245 1 4 $a The Effects of Obesity, Chronic Stress, and Exercise on Pancreatic Health.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2019
300 $a 91 p.
500 $a Source: Masters Abstracts International, Volume: 81-04.
500 $a Advisor: Bryner, Randall;Chantler, Paul.
502 $a Thesis (M.S.)--West Virginia University, 2019.
506 $a This item must not be sold to any third party vendors.
520 $a Obesity is concomitant with hyperglycemic conditions, increased proinflammatory cytokines, and increased oxidative stress. Under hyperglycemia, thioredoxin interacting protein (TXNIP) is increased and causes increased oxidative stress and pancreatic β-cell apoptosis. Chronic stress is associated with increased glucocorticoid levels and a proinflammatory environment. The purpose of this study was to examine the effects of obesity, chronic stress, and exercise on pancreatic health.Lean Zucker Rats (LZRs) and Obese Zucker Rats (OZRs) were randomly assigned to four groups: 1) sedentary controls (C: n=8 per); 2) unpredictable chronic mild stress (UCMS) (S: n=8); 3) exercise (E: n=8); and 4) combined UCMS and exercise (ExS: n=8). Exercise rats underwent 8 weeks of treadmill running for 60 minutes. Stress rats were subjected to UCMS that included cage tilt, no bedding, damp bedding, bath, social stress, and altered light-dark cycles for 8 hours a day, 5 days a week for 8 weeks. Pancreas tissue was obtained from rats around 20 weeks of age. Total pancreatic TXNIP protein was quantified, including total pancreatic cytokine expression for IL-1β, TNF-α, IL-4, and IL-10. Using immunohistochemistry, β-cell and α-cell counting, islet area measurements, and β-cell to α-cell ratio were examined. TUNEL staining, to determine apoptosis, was examined in pancreatic lysates.OZRs had higher insulin, glucose, and body mass compared to LZRs, as wells as higher β-cell and α-cell number and islet area (p<0.05).In a model of obesity and metabolic syndrome, the pancreas appeared to be stimulated to grow as indicated by greater numbers of β- and α-cells and larger islets even in the presence of slightly higher pancreatic TXNIP and TNF-α. Obesity resulted in an increased level of inflammation and reduced antioxidant potential within the pancreas as indicated by significantly higher TXNIP, IL-1β, and TNF-α. Eight weeks of treadmill running reversed this effect. Exercise training was also able to reduced TXNIP within the pancreas as a result of stress.
590 $a School code: 0256.
650 4 $a Physiology. $3 518431
650 4 $a Kinesiology. $3 517627
690 $a 0575
690 $a 0719
710 2 $a West Virginia University. $3 1017532
773 0 $t Masters Abstracts International $g 81-04.
790 $a 0256
791 $a M.S.
792 $a 2019
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27527115