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Associations between Toxic Metals an...

Bommarito, Paige Annalise.

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Associations between Toxic Metals and Preeclampsia: An Interdisciplinary Approach to Understanding Disease Etiology.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Associations between Toxic Metals and Preeclampsia: An Interdisciplinary Approach to Understanding Disease Etiology./
作者:	Bommarito, Paige Annalise.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
面頁冊數:	161 p.
附註:	Source: Dissertations Abstracts International, Volume: 82-01, Section: B.
Contained By:	Dissertations Abstracts International82-01B.
標題:	Epidemiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27739975
ISBN:	9798641740904

Associations between Toxic Metals and Preeclampsia: An Interdisciplinary Approach to Understanding Disease Etiology.
Bommarito, Paige Annalise.

Associations between Toxic Metals and Preeclampsia: An Interdisciplinary Approach to Understanding Disease Etiology. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 161 p.

Source: Dissertations Abstracts International, Volume: 82-01, Section: B.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2020.

This item must not be sold to any third party vendors.

Preeclampsia is a reproductive disorder originating in the placenta. During pregnancy, exposure to toxic metals may promote the development of preeclampsia by altering processes occurring during placentation, giving rise to a shallow placenta with reduced vascularization. Using transdisciplinary scientific approaches, I investigated the relationship between toxic metals and preeclampsia. First, we examined the association between urinary trace metals and biomarkers of preeclampsia risk in a prospective birth cohort. Findings were followed with additional studies of the relationship between placental metals concentrations and the expression of genes related to placentation. Lastly, a toxicological approach was used to demonstrate clear links between cadmium exposure, gene expression, and trophoblast migration in an in vitro placental model. Throughout all approaches, I additionally investigated potential interactions between toxic and essential metals. Taken together, findings from these studies suggest that cadmium may promote the development of preeclampsia by altering processes related to placentation in ways consistent with those observed during preeclampsia. Moreover, these studies demonstrate that essential metals may act to prevent the adverse effects of toxic metals exposure within the placenta. Individuals with low exposure to essential metals may represent a population of pregnant women particularly susceptible to the effects of toxic metals exposure.

ISBN: 9798641740904Subjects--Topical Terms:

568544
Epidemiology.
Subjects--Index Terms:

Cadmium

Associations between Toxic Metals and Preeclampsia: An Interdisciplinary Approach to Understanding Disease Etiology.
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653 $a Toxic metals
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