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The Role of N6-Methyladenosine RNA M...

Lee, Heather M.

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The Role of N6-Methyladenosine RNA Methylation in the Regulation of Hematopoietic Stem Cells.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Role of N6-Methyladenosine RNA Methylation in the Regulation of Hematopoietic Stem Cells./
Author:	Lee, Heather M.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	128 p.
Notes:	Source: Dissertations Abstracts International, Volume: 81-07, Section: B.
Contained By:	Dissertations Abstracts International81-07B.
Subject:	Cellular biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27666687
ISBN:	9781392464809

The Role of N6-Methyladenosine RNA Methylation in the Regulation of Hematopoietic Stem Cells.
Lee, Heather M.

The Role of N6-Methyladenosine RNA Methylation in the Regulation of Hematopoietic Stem Cells. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 128 p.

Source: Dissertations Abstracts International, Volume: 81-07, Section: B.

Thesis (Ph.D.)--Columbia University, 2020.

This item must not be sold to any third party vendors.

Hematopoietic stem cells (HSCs) give rise to all blood cells and are characterized by their ability for life-long self-renewal and multilineage differentiation. HSC function is regulated by complex cell-intrinsic and -extrinsic pathways, but these regulatory mechanisms are not completely understood. Recent work has demonstrated that the epitranscriptional modification N6-methyladenosine (m6A) has important roles in the regulation of many physiologic and pathologic processes in various cell types, but it was previously unknown if and how m6A may regulate adult HSC function. In this work, I uncover the role for m6A in HSC regulation, both cell-intrinsically in regulating HSC differentiation and cell-extrinsically by regulating the formation the HSC bone marrow niche.

ISBN: 9781392464809Subjects--Topical Terms:

3172791
Cellular biology.
Subjects--Index Terms:

Hematopoietic stem cells

The Role of N6-Methyladenosine RNA Methylation in the Regulation of Hematopoietic Stem Cells.
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020 $a 9781392464809
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100 1 $a Lee, Heather M. $3 3550398
245 1 4 $a The Role of N6-Methyladenosine RNA Methylation in the Regulation of Hematopoietic Stem Cells.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2020
300 $a 128 p.
500 $a Source: Dissertations Abstracts International, Volume: 81-07, Section: B.
500 $a Advisor: Ding, Lei.
502 $a Thesis (Ph.D.)--Columbia University, 2020.
506 $a This item must not be sold to any third party vendors.
520 $a Hematopoietic stem cells (HSCs) give rise to all blood cells and are characterized by their ability for life-long self-renewal and multilineage differentiation. HSC function is regulated by complex cell-intrinsic and -extrinsic pathways, but these regulatory mechanisms are not completely understood. Recent work has demonstrated that the epitranscriptional modification N6-methyladenosine (m6A) has important roles in the regulation of many physiologic and pathologic processes in various cell types, but it was previously unknown if and how m6A may regulate adult HSC function. In this work, I uncover the role for m6A in HSC regulation, both cell-intrinsically in regulating HSC differentiation and cell-extrinsically by regulating the formation the HSC bone marrow niche.
590 $a School code: 0054.
650 4 $a Cellular biology. $3 3172791
650 4 $a Molecular biology. $3 517296
653 $a Hematopoietic stem cells
653 $a RNA modification
653 $a Stem cell niche
690 $a 0379
690 $a 0307
710 2 $a Columbia University. $b Cellular, Molecular and Biomedical Studies. $3 2099963
773 0 $t Dissertations Abstracts International $g 81-07B.
790 $a 0054
791 $a Ph.D.
792 $a 2020
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27666687