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Mechanisms of Post-transcriptional C...

Zahr, Siraj.

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Mechanisms of Post-transcriptional Control in Mammalian Neural Stem Cells.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Mechanisms of Post-transcriptional Control in Mammalian Neural Stem Cells./
作者:	Zahr, Siraj.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
面頁冊數:	252 p.
附註:	Source: Dissertations Abstracts International, Volume: 81-05, Section: B.
Contained By:	Dissertations Abstracts International81-05B.
標題:	Developmental biology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13899951
ISBN:	9781392526088

Mechanisms of Post-transcriptional Control in Mammalian Neural Stem Cells.
Zahr, Siraj.

Mechanisms of Post-transcriptional Control in Mammalian Neural Stem Cells. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 252 p.

Source: Dissertations Abstracts International, Volume: 81-05, Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2019.

This item must not be sold to any third party vendors.

The diverse types of neurons that populate the mammalian forebrain are the fundamental requirement for the assembly of complex circuitry. However, the mechanisms regulating the genesis of these distinct neuronal populations from neural precursor cells (NPCs) are still not well understood. In this thesis, I address the question of whether post-transcriptional mechanisms regulate neuronal differentiation and fate specification within the developing forebrain. First, I show that embryonic NPCs are transcriptionally primed to make diverse neuronal subtypes, and that a Pum2-4E-T complex represses the translation of neuronal specifier mRNAs to ensure the appropriate temporal specification of daughter neurons. Second, I show that 4E-T mediated translational repression continues to act as a critical regulator of NPC maintenance and differentiation at postnatal stages. Based on the work presented in this thesis, I propose that translational repression mechanisms act to ensure the appropriate differentiation of transcriptionally primed NPCs in response to rapidly changing environmental cues.

ISBN: 9781392526088Subjects--Topical Terms:

592588
Developmental biology.
Subjects--Index Terms:

Cell fate specification

Mechanisms of Post-transcriptional Control in Mammalian Neural Stem Cells.
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500 $a Advisor: Miller, Freda.
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520 $a The diverse types of neurons that populate the mammalian forebrain are the fundamental requirement for the assembly of complex circuitry. However, the mechanisms regulating the genesis of these distinct neuronal populations from neural precursor cells (NPCs) are still not well understood. In this thesis, I address the question of whether post-transcriptional mechanisms regulate neuronal differentiation and fate specification within the developing forebrain. First, I show that embryonic NPCs are transcriptionally primed to make diverse neuronal subtypes, and that a Pum2-4E-T complex represses the translation of neuronal specifier mRNAs to ensure the appropriate temporal specification of daughter neurons. Second, I show that 4E-T mediated translational repression continues to act as a critical regulator of NPC maintenance and differentiation at postnatal stages. Based on the work presented in this thesis, I propose that translational repression mechanisms act to ensure the appropriate differentiation of transcriptionally primed NPCs in response to rapidly changing environmental cues.
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653 $a Cell fate specification
653 $a Immunohistochemistry
653 $a Neocortex
653 $a Neural stem cells
653 $a Post-transcriptional control
653 $a Single-cell RNA sequencing
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