東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Investigating the Role of Metabolism...

Flores, Aimee Alyssa.

FindBook

Google Book

Amazon

博客來

Investigating the Role of Metabolism in Tissue Homeostasis and Tumor Initiation by Hair Follicle Stem Cells.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Investigating the Role of Metabolism in Tissue Homeostasis and Tumor Initiation by Hair Follicle Stem Cells./
作者:	Flores, Aimee Alyssa.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	131 p.
附註:	Source: Dissertations Abstracts International, Volume: 79-12, Section: B.
Contained By:	Dissertations Abstracts International79-12B.
標題:	Molecular biology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10822711
ISBN:	9780355981735

Investigating the Role of Metabolism in Tissue Homeostasis and Tumor Initiation by Hair Follicle Stem Cells.
Flores, Aimee Alyssa.

Investigating the Role of Metabolism in Tissue Homeostasis and Tumor Initiation by Hair Follicle Stem Cells. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 131 p.

Source: Dissertations Abstracts International, Volume: 79-12, Section: B.

Thesis (Ph.D.)--University of California, Los Angeles, 2018.

This item is not available from ProQuest Dissertations & Theses.

For an increasing number of cancers, the cell of origin has been demonstrated to be the resident adult stem cell. One such cancer is squamous cell carcinoma, for which recent studies in our lab traced its origin to the hair follicle stem cells. Malignant transformation is thought to coincide with a dramatic shift towards the use of glycolysis and establishment of a 'Warburg' state - increased metabolism of glucose to lactate. How the Warburg Effect is established during tumor initiation and progression in vivo remains unclear. The current consensus is that the bulk of the energy generated in most adult tissue cells is created by oxidative phosphorylation, while more highly proliferative cells, such as activated immune cells and cells transformed to make a tumor, mainly use glycolysis. Little is known about how individual cell types generate energy in vivo, however, and how their metabolism influences basic cell fate decisions such as cell division, migration or differentiation. Using genetically engineered mouse models that allow the study of both tissue homeostasis and the Warburg Effect in vivo, I have made important observations that provide the basis for new investigations into the role of metabolism in key cell fate decisions by adult stem cells. In this dissertation I present data indicating that hair follicle stem cells possess a unique metabolic profile that may be critical for their maintenance and for their response to oncogenic insults. Importantly, they suggest the possibility that the "Warburg Effect" is the result of the expansion of an already glycolytic subpopulation, namely the hair follicle stem cells.

ISBN: 9780355981735Subjects--Topical Terms:

517296
Molecular biology.
Subjects--Index Terms:

Adult stem cells

Investigating the Role of Metabolism in Tissue Homeostasis and Tumor Initiation by Hair Follicle Stem Cells.
LDR:03010nmm a2200397 4500 001 2272228
005 20201105110002.5
008 220629s2018 ||||||||||||||||| ||eng d
020 $a 9780355981735
035 $a (MiAaPQ)AAI10822711
035 $a (MiAaPQ)ucla:16708
035 $a AAI10822711
040 $a MiAaPQ $c MiAaPQ
100 1 $a Flores, Aimee Alyssa. $3 3549659
245 1 0 $a Investigating the Role of Metabolism in Tissue Homeostasis and Tumor Initiation by Hair Follicle Stem Cells.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 131 p.
500 $a Source: Dissertations Abstracts International, Volume: 79-12, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Lowry, William E.
502 $a Thesis (Ph.D.)--University of California, Los Angeles, 2018.
506 $a This item is not available from ProQuest Dissertations & Theses.
506 $a This item must not be sold to any third party vendors.
520 $a For an increasing number of cancers, the cell of origin has been demonstrated to be the resident adult stem cell. One such cancer is squamous cell carcinoma, for which recent studies in our lab traced its origin to the hair follicle stem cells. Malignant transformation is thought to coincide with a dramatic shift towards the use of glycolysis and establishment of a 'Warburg' state - increased metabolism of glucose to lactate. How the Warburg Effect is established during tumor initiation and progression in vivo remains unclear. The current consensus is that the bulk of the energy generated in most adult tissue cells is created by oxidative phosphorylation, while more highly proliferative cells, such as activated immune cells and cells transformed to make a tumor, mainly use glycolysis. Little is known about how individual cell types generate energy in vivo, however, and how their metabolism influences basic cell fate decisions such as cell division, migration or differentiation. Using genetically engineered mouse models that allow the study of both tissue homeostasis and the Warburg Effect in vivo, I have made important observations that provide the basis for new investigations into the role of metabolism in key cell fate decisions by adult stem cells. In this dissertation I present data indicating that hair follicle stem cells possess a unique metabolic profile that may be critical for their maintenance and for their response to oncogenic insults. Importantly, they suggest the possibility that the "Warburg Effect" is the result of the expansion of an already glycolytic subpopulation, namely the hair follicle stem cells.
590 $a School code: 0031.
650 4 $a Molecular biology. $3 517296
650 4 $a Cellular biology. $3 3172791
650 4 $a Developmental biology. $3 592588
653 $a Adult stem cells
653 $a Cancer metabolism
653 $a Cellular metabolism
653 $a Hair follicle stem cells
690 $a 0307
690 $a 0379
690 $a 0758
710 2 $a University of California, Los Angeles. $b Molecular Biology 0573. $3 2102169
773 0 $t Dissertations Abstracts International $g 79-12B.
790 $a 0031
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10822711