東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Prenatal Exposure to Organophosphate...

Doherty, Brett Thomas.

FindBook

Google Book

Amazon

博客來

Prenatal Exposure to Organophosphate Esters and Cognitive and Behavioral Development in Young Children.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Prenatal Exposure to Organophosphate Esters and Cognitive and Behavioral Development in Young Children./
作者:	Doherty, Brett Thomas.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	215 p.
附註:	Source: Dissertations Abstracts International, Volume: 80-12, Section: B.
Contained By:	Dissertations Abstracts International80-12B.
標題:	Obstetrics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10932589
ISBN:	9781392199350

Prenatal Exposure to Organophosphate Esters and Cognitive and Behavioral Development in Young Children.
Doherty, Brett Thomas.

Prenatal Exposure to Organophosphate Esters and Cognitive and Behavioral Development in Young Children. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 215 p.

Source: Dissertations Abstracts International, Volume: 80-12, Section: B.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018.

This item must not be sold to any third party vendors.

Organophosphate esters (OPEs) are chemical additives applied to a variety of consumer products as flame retardants and for other purposes. OPEs volatilize from products and are prevalent in the environment and in humans. OPEs are potentially developmentally toxic, but epidemiologic evidence is limited.We investigated developmental effects of prenatal OPE exposure with data from the Pregnancy, Infection, and Nutrition (PIN3), PIN Postpartum, and PIN Kids studies. The PIN3 Study is a prospective birth cohort study of pregnant women in North Carolina between 2001 and 2005. We measured OPE metabolite concentrations in prenatal urine, including diphenyl phosphate (DPHP), bis(1,3-dichloro-2-propyl phosphate) (BDCIPP), isopropyl-phenyl phenyl phosphate (ip-PPP), and 1-hydroxyl-2-propyl bis(1-chloro-2-propyl) phosphate (BCIPHIPP). The PIN studies assessed children's cognitive and behavioral development using the Mullen Scales of Early Learning (MSEL) at 12 and 36 months, the MacArthur-Bates Communicative Development Inventories (MB-CDI) at 12 and 30 months, the Infant-Toddler Social-Emotional Assessment at 24 months, and the Behavioral Assessment Scale for Children (2nd Edition, BASC-2) at 36 months. We estimated the covariate-adjusted change in performance on these developmental assessments per interquartile range (IQR) increase in specific gravity-corrected, log-transformed OPE metabolite concentrations, and investigated effect measure modification of these associations by child's sex.Higher ip-PPP concentrations were associated with poorer overall cognitive development at 36 months of age (MSEL Cognitive Composite Score (β: -3.30; 95% CI: -6.29, -0.32), primarily driven by the Fine Motor and Expressive Language subscales. Conversely, ip-PPP was associated with fewer internalizing symptoms on the BASC-2 (β: -1.77; 95% CI: -3.24, -0.29). BDCIPP concentrations were associated with more externalizing behaviors on the BASC-2 (β: 2.32; 95% CI: 0.85, 3.79) and ITSEA (β: 2.07; 95% CI: 0.29, 3.85). Other OPE metabolites were not strongly associated with developmental scores. We did not observe strong evidence of effect measure modification by child's sex.We observed that two OPE metabolites measured in prenatal urine were associated with poorer cognitive development and more behavioral symptoms; suggesting these chemicals should be further investigated for developmental toxicity.

ISBN: 9781392199350Subjects--Topical Terms:

634501
Obstetrics.
Subjects--Index Terms:

Behavior

Prenatal Exposure to Organophosphate Esters and Cognitive and Behavioral Development in Young Children.
LDR:03779nmm a2200433 4500 001 2271649
005 20201030090740.5
008 220629s2018 ||||||||||||||||| ||eng d
020 $a 9781392199350
035 $a (MiAaPQ)AAI10932589
035 $a (MiAaPQ)unc:18133
035 $a AAI10932589
040 $a MiAaPQ $c MiAaPQ
100 1 $a Doherty, Brett Thomas. $3 3549062
245 1 0 $a Prenatal Exposure to Organophosphate Esters and Cognitive and Behavioral Development in Young Children.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 215 p.
500 $a Source: Dissertations Abstracts International, Volume: 80-12, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Daniels, Julie L.
502 $a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2018.
506 $a This item must not be sold to any third party vendors.
520 $a Organophosphate esters (OPEs) are chemical additives applied to a variety of consumer products as flame retardants and for other purposes. OPEs volatilize from products and are prevalent in the environment and in humans. OPEs are potentially developmentally toxic, but epidemiologic evidence is limited.We investigated developmental effects of prenatal OPE exposure with data from the Pregnancy, Infection, and Nutrition (PIN3), PIN Postpartum, and PIN Kids studies. The PIN3 Study is a prospective birth cohort study of pregnant women in North Carolina between 2001 and 2005. We measured OPE metabolite concentrations in prenatal urine, including diphenyl phosphate (DPHP), bis(1,3-dichloro-2-propyl phosphate) (BDCIPP), isopropyl-phenyl phenyl phosphate (ip-PPP), and 1-hydroxyl-2-propyl bis(1-chloro-2-propyl) phosphate (BCIPHIPP). The PIN studies assessed children's cognitive and behavioral development using the Mullen Scales of Early Learning (MSEL) at 12 and 36 months, the MacArthur-Bates Communicative Development Inventories (MB-CDI) at 12 and 30 months, the Infant-Toddler Social-Emotional Assessment at 24 months, and the Behavioral Assessment Scale for Children (2nd Edition, BASC-2) at 36 months. We estimated the covariate-adjusted change in performance on these developmental assessments per interquartile range (IQR) increase in specific gravity-corrected, log-transformed OPE metabolite concentrations, and investigated effect measure modification of these associations by child's sex.Higher ip-PPP concentrations were associated with poorer overall cognitive development at 36 months of age (MSEL Cognitive Composite Score (β: -3.30; 95% CI: -6.29, -0.32), primarily driven by the Fine Motor and Expressive Language subscales. Conversely, ip-PPP was associated with fewer internalizing symptoms on the BASC-2 (β: -1.77; 95% CI: -3.24, -0.29). BDCIPP concentrations were associated with more externalizing behaviors on the BASC-2 (β: 2.32; 95% CI: 0.85, 3.79) and ITSEA (β: 2.07; 95% CI: 0.29, 3.85). Other OPE metabolites were not strongly associated with developmental scores. We did not observe strong evidence of effect measure modification by child's sex.We observed that two OPE metabolites measured in prenatal urine were associated with poorer cognitive development and more behavioral symptoms; suggesting these chemicals should be further investigated for developmental toxicity.
590 $a School code: 0153.
650 4 $a Obstetrics. $3 634501
650 4 $a Environmental Health. $3 578282
650 4 $a Public health. $3 534748
650 4 $a Developmental biology. $3 592588
650 4 $a Epidemiology. $3 568544
653 $a Behavior
653 $a Cognitive
653 $a Flame retardant
653 $a Neurodevelopment
653 $a Organophosphate
653 $a Organophosphate ester
690 $a 0380
690 $a 0470
690 $a 0573
690 $a 0758
690 $a 0766
710 2 $a The University of North Carolina at Chapel Hill. $b Epidemiology. $3 1269376
773 0 $t Dissertations Abstracts International $g 80-12B.
790 $a 0153
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10932589