東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Characterizing Inhibitors of the Bac...

Morgan, Jessica M.

Linked to FindBook

Google Book

Amazon

博客來

Characterizing Inhibitors of the Bacterial Type Three Secretion System.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Characterizing Inhibitors of the Bacterial Type Three Secretion System./
Author:	Morgan, Jessica M.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	114 p.
Notes:	Source: Dissertations Abstracts International, Volume: 80-05, Section: B.
Contained By:	Dissertations Abstracts International80-05B.
Subject:	Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10929879
ISBN:	9780438534377

Characterizing Inhibitors of the Bacterial Type Three Secretion System.
Morgan, Jessica M.

Characterizing Inhibitors of the Bacterial Type Three Secretion System. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 114 p.

Source: Dissertations Abstracts International, Volume: 80-05, Section: B.

Thesis (Ph.D.)--University of California, Santa Cruz, 2018.

This item is not available from ProQuest Dissertations & Theses.

The aims of my dissertation research were to characterize the activity of inhibitors targeting the bacterial virulence factor, the type III secretion system (T3SS). The T3SS is a needle-like apparatus used by dozens of bacterial pathogens to directly deposit bacterial effector toxins inside the cytoplasm of target host cells. This virulence factor is typically essential for bacterial survival and replication within the host, and dozens of T3SS- positive pathogens are the causative agents of relevant health threats. Importantly, these T3SSs are highly conserved between bacterial species that possess them, making them an attractive potential drug target. The first half of this work focuses on taking advantage of the tightly regulated, processional assembly and deployment of the T3SS and designing and optimizing assays we can use to probe for inhibitory activity at discreet stages throughout this process. The second goal of my dissertation research was to employ this assay to characterize an inhibitor of the T3SS, piericidin A1, and have determined the molecule inhibits T3SS needle assembly.

ISBN: 9780438534377Subjects--Topical Terms:

536250
Microbiology.
Subjects--Index Terms:

Gram-negative bacteria

Characterizing Inhibitors of the Bacterial Type Three Secretion System.
LDR:02481nmm a2200421 4500 001 2271648
005 20201030090739.5
008 220629s2018 ||||||||||||||||| ||eng d
020 $a 9780438534377
035 $a (MiAaPQ)AAI10929879
035 $a (MiAaPQ)ucsc:11610
035 $a AAI10929879
040 $a MiAaPQ $c MiAaPQ
100 1 $a Morgan, Jessica M. $3 3549061
245 1 0 $a Characterizing Inhibitors of the Bacterial Type Three Secretion System.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 114 p.
500 $a Source: Dissertations Abstracts International, Volume: 80-05, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Stone, Victoria A.
502 $a Thesis (Ph.D.)--University of California, Santa Cruz, 2018.
506 $a This item is not available from ProQuest Dissertations & Theses.
506 $a This item must not be sold to any third party vendors.
520 $a The aims of my dissertation research were to characterize the activity of inhibitors targeting the bacterial virulence factor, the type III secretion system (T3SS). The T3SS is a needle-like apparatus used by dozens of bacterial pathogens to directly deposit bacterial effector toxins inside the cytoplasm of target host cells. This virulence factor is typically essential for bacterial survival and replication within the host, and dozens of T3SS- positive pathogens are the causative agents of relevant health threats. Importantly, these T3SSs are highly conserved between bacterial species that possess them, making them an attractive potential drug target. The first half of this work focuses on taking advantage of the tightly regulated, processional assembly and deployment of the T3SS and designing and optimizing assays we can use to probe for inhibitory activity at discreet stages throughout this process. The second goal of my dissertation research was to employ this assay to characterize an inhibitor of the T3SS, piericidin A1, and have determined the molecule inhibits T3SS needle assembly.
590 $a School code: 0036.
650 4 $a Microbiology. $3 536250
650 4 $a Environmental Health. $3 578282
650 4 $a Biochemistry. $3 518028
650 4 $a Pathology. $3 643180
650 4 $a Virology. $3 642304
653 $a Gram-negative bacteria
653 $a T3SS deployment
653 $a bacterial virulence factor
653 $a facultative pathogens
690 $a 0410
690 $a 0470
690 $a 0487
690 $a 0571
690 $a 0720
710 2 $a University of California, Santa Cruz. $b Chemistry. $3 2094214
773 0 $t Dissertations Abstracts International $g 80-05B.
790 $a 0036
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10929879