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Post-translational Modification and ...

Che, Xun.

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Post-translational Modification and Functional Regulation of Aryl Hydrocarbon Receptor: A Gene-environment Interaction Study.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Post-translational Modification and Functional Regulation of Aryl Hydrocarbon Receptor: A Gene-environment Interaction Study./
作者:	Che, Xun.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	122 p.
附註:	Source: Dissertations Abstracts International, Volume: 80-09, Section: B.
Contained By:	Dissertations Abstracts International80-09B.
標題:	Biology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10928115
ISBN:	9781392004265

Post-translational Modification and Functional Regulation of Aryl Hydrocarbon Receptor: A Gene-environment Interaction Study.
Che, Xun.

Post-translational Modification and Functional Regulation of Aryl Hydrocarbon Receptor: A Gene-environment Interaction Study. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 122 p.

Source: Dissertations Abstracts International, Volume: 80-09, Section: B.

Thesis (Ph.D.)--New York University, 2018.

This item must not be added to any third party search indexes.

Aryl Hydrocarbon Receptor (AhR) plays a crucial role in mediating metabolism of a wide range of environmental toxicants including polychlorinated biphenyls, polycyclic aromatic hydrocarbons, and dioxins. Extensive research in the past strongly suggests that deregulated activities of AhR may be responsible for its carcinogenic effect after exposure to multiple environmental toxicants. In this study I found that nickel chloride significantly blocked the induction of P450 genes by dioxin or benzo[α]pyrene. I also investigated whether lysine modifications affected AhR functions. I demonstrated that AhR was modified by SUMO3. Moreover, substitutions of lysines with arginines within the bHLH domain suppressed the ability of AhR to transactivate P450 genes upon exposure to dioxins.

ISBN: 9781392004265Subjects--Topical Terms:

522710
Biology.
Subjects--Index Terms:

Aryl hydrocarbon receptor

Post-translational Modification and Functional Regulation of Aryl Hydrocarbon Receptor: A Gene-environment Interaction Study.
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520 $a Aryl Hydrocarbon Receptor (AhR) plays a crucial role in mediating metabolism of a wide range of environmental toxicants including polychlorinated biphenyls, polycyclic aromatic hydrocarbons, and dioxins. Extensive research in the past strongly suggests that deregulated activities of AhR may be responsible for its carcinogenic effect after exposure to multiple environmental toxicants. In this study I found that nickel chloride significantly blocked the induction of P450 genes by dioxin or benzo[α]pyrene. I also investigated whether lysine modifications affected AhR functions. I demonstrated that AhR was modified by SUMO3. Moreover, substitutions of lysines with arginines within the bHLH domain suppressed the ability of AhR to transactivate P450 genes upon exposure to dioxins.
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