東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Post-translational Modification and ...

Che, Xun.

Linked to FindBook

Google Book

Amazon

博客來

Post-translational Modification and Functional Regulation of Aryl Hydrocarbon Receptor: A Gene-environment Interaction Study.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Post-translational Modification and Functional Regulation of Aryl Hydrocarbon Receptor: A Gene-environment Interaction Study./
Author:	Che, Xun.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	122 p.
Notes:	Source: Dissertations Abstracts International, Volume: 80-09, Section: B.
Contained By:	Dissertations Abstracts International80-09B.
Subject:	Biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10928115
ISBN:	9781392004265

Post-translational Modification and Functional Regulation of Aryl Hydrocarbon Receptor: A Gene-environment Interaction Study.
Che, Xun.

Post-translational Modification and Functional Regulation of Aryl Hydrocarbon Receptor: A Gene-environment Interaction Study. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 122 p.

Source: Dissertations Abstracts International, Volume: 80-09, Section: B.

Thesis (Ph.D.)--New York University, 2018.

This item must not be added to any third party search indexes.

Aryl Hydrocarbon Receptor (AhR) plays a crucial role in mediating metabolism of a wide range of environmental toxicants including polychlorinated biphenyls, polycyclic aromatic hydrocarbons, and dioxins. Extensive research in the past strongly suggests that deregulated activities of AhR may be responsible for its carcinogenic effect after exposure to multiple environmental toxicants. In this study I found that nickel chloride significantly blocked the induction of P450 genes by dioxin or benzo[α]pyrene. I also investigated whether lysine modifications affected AhR functions. I demonstrated that AhR was modified by SUMO3. Moreover, substitutions of lysines with arginines within the bHLH domain suppressed the ability of AhR to transactivate P450 genes upon exposure to dioxins.

ISBN: 9781392004265Subjects--Topical Terms:

522710
Biology.
Subjects--Index Terms:

Aryl hydrocarbon receptor

Post-translational Modification and Functional Regulation of Aryl Hydrocarbon Receptor: A Gene-environment Interaction Study.
LDR:02193nmm a2200421 4500 001 2271647
005 20201030090739.5
008 220629s2018 ||||||||||||||||| ||eng d
020 $a 9781392004265
035 $a (MiAaPQ)AAI10928115
035 $a (MiAaPQ)nyu:13374
035 $a AAI10928115
040 $a MiAaPQ $c MiAaPQ
100 1 $a Che, Xun. $3 3549060
245 1 0 $a Post-translational Modification and Functional Regulation of Aryl Hydrocarbon Receptor: A Gene-environment Interaction Study.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 122 p.
500 $a Source: Dissertations Abstracts International, Volume: 80-09, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Dai, Wei.
502 $a Thesis (Ph.D.)--New York University, 2018.
506 $a This item must not be added to any third party search indexes.
506 $a This item must not be sold to any third party vendors.
520 $a Aryl Hydrocarbon Receptor (AhR) plays a crucial role in mediating metabolism of a wide range of environmental toxicants including polychlorinated biphenyls, polycyclic aromatic hydrocarbons, and dioxins. Extensive research in the past strongly suggests that deregulated activities of AhR may be responsible for its carcinogenic effect after exposure to multiple environmental toxicants. In this study I found that nickel chloride significantly blocked the induction of P450 genes by dioxin or benzo[α]pyrene. I also investigated whether lysine modifications affected AhR functions. I demonstrated that AhR was modified by SUMO3. Moreover, substitutions of lysines with arginines within the bHLH domain suppressed the ability of AhR to transactivate P450 genes upon exposure to dioxins.
590 $a School code: 0146.
650 4 $a Biology. $3 522710
650 4 $a Toxicology. $3 556884
650 4 $a Environmental Health. $3 578282
653 $a Aryl hydrocarbon receptor
653 $a Cytochrome p450
653 $a Nickel chloride
653 $a Post-translational modification
653 $a Sumoylation
653 $a TCDD
690 $a 0306
690 $a 0383
690 $a 0470
710 2 $a New York University. $b Environmental Health Science. $3 1064529
773 0 $t Dissertations Abstracts International $g 80-09B.
790 $a 0146
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10928115