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A family-based association study of ...

Jian, Xueqiu.

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A family-based association study of conduct disorder.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	A family-based association study of conduct disorder./
作者:	Jian, Xueqiu.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2010,
面頁冊數:	58 p.
附註:	Source: Masters Abstracts International, Volume: 71-12.
Contained By:	Masters Abstracts International71-12.
標題:	Mental health. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1484814
ISBN:	9781124007946

A family-based association study of conduct disorder.
Jian, Xueqiu.

A family-based association study of conduct disorder. - Ann Arbor : ProQuest Dissertations & Theses, 2010 - 58 p.

Source: Masters Abstracts International, Volume: 71-12.

Thesis (M.P.H.)--East Tennessee State University, 2010.

Conduct disorder is a psychiatric syndrome in childhood and adolescence that is one of the most common childhood disorders with continuously increasing prevalence but uncertain pathogenesis. We performed a genome-wide, family-based association study of CD using P2BAT/FBAT software. The data were gathered from Collaborative Study on the Genetics of Alcoholism (COGA) and International Multi-Center ADHD Genetics Project (IMAGE). Using COGA data, we identified 20 markers that showed suggestive associations (p<10-3) with CD. Nine of them are located in known genes. Two genes, ADAM10 and CAMK2A, which had been reported associated with Alzheimer's disease (AD), bipolar disorder, and depression, were of more concern. Using IMAGE sample, our results were well replicated. This study identified several CD associated genetic variants, especially 2 novel candidate genes. These findings may serve as a resource for replication in other populations to elucidate the potential role of these genetic variants in CD.

ISBN: 9781124007946Subjects--Topical Terms:

534751
Mental health.

A family-based association study of conduct disorder.
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