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Synthesis and Study of Inflammation ...

Lee, Sangeun.

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Synthesis and Study of Inflammation Responsive Polymeric Particles.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Synthesis and Study of Inflammation Responsive Polymeric Particles./
作者:	Lee, Sangeun.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	150 p.
附註:	Source: Dissertations Abstracts International, Volume: 79-10, Section: B.
Contained By:	Dissertations Abstracts International79-10B.
標題:	Chemical engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10688848
ISBN:	9780355811360

Synthesis and Study of Inflammation Responsive Polymeric Particles.
Lee, Sangeun.

Synthesis and Study of Inflammation Responsive Polymeric Particles. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 150 p.

Source: Dissertations Abstracts International, Volume: 79-10, Section: B.

Thesis (Ph.D.)--University of California, San Diego, 2018.

This item is not available from ProQuest Dissertations & Theses.

Recently, attention in chronic inflammation has been increasing since it is closely related to various diseases, such as rheumatoid arthritis, Huntington's, Parkinson's, Alzheimer's diseases, and even in cancers. Inflammation is an immune response against pathogens, damaged cells or irritants. In the process, immune cells activate overproduction of reactive oxygen species (ROS) and decrease pH of the inflammatory area. Therefore, these two biomarkers are available as stimuli for controlled release of drug delivery system (DDS). DDS is intended to encapsulate conventional medicines in vehicles and safely transport the therapeutic agents only to disease area, minimizing adverse effects on normal tissue and maximizing the effect on the target. The ultimate goal of the DDS is to find optimized materials as a delivery vehicle. Polymers are proposed as suitable biomedical materials for several reasons. Firstly, both of hydrophobic conventional drugs and hydrophilic enzymes and proteins can be encapsulated according to polymer nature. Secondly, a wide range of chemical modification is applicable. The easy modification makes efficient delivery possible by controlling the release of cargo by disease-specific stimuli. Based on these advantages, inflammation-responsive polymeric carriers are introduced in here. In chapter 1, ROS-responsive polymeric degradation via chemical amplification is demonstrated. This polymer degraded 12 times faster compared with its control polymer by employing chemical amplification strategy. In chapter 2, anti-inflammatory drug conjugated polymer is introduced. To maximize drug delivery efficiency, an anti-inflammatory drug was conjugated onto dextran using a ROS-responsive linker. This polymeric material not only releases the anti-inflammatory drug in inflammatory cells but also increased drug efficacy by reducing ROS level in inflammation. In chapter 3, bioresponsive prophylaxis polymeric materials for acute inflammation is demonstrated both in vitro and in vivo.

ISBN: 9780355811360Subjects--Topical Terms:

560457
Chemical engineering.
Subjects--Index Terms:

Inflammation

Synthesis and Study of Inflammation Responsive Polymeric Particles.
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500 $a Advisor: Almutairi, Adah.
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506 $a This item must not be added to any third party search indexes.
506 $a This item must not be sold to any third party vendors.
520 $a Recently, attention in chronic inflammation has been increasing since it is closely related to various diseases, such as rheumatoid arthritis, Huntington's, Parkinson's, Alzheimer's diseases, and even in cancers. Inflammation is an immune response against pathogens, damaged cells or irritants. In the process, immune cells activate overproduction of reactive oxygen species (ROS) and decrease pH of the inflammatory area. Therefore, these two biomarkers are available as stimuli for controlled release of drug delivery system (DDS). DDS is intended to encapsulate conventional medicines in vehicles and safely transport the therapeutic agents only to disease area, minimizing adverse effects on normal tissue and maximizing the effect on the target. The ultimate goal of the DDS is to find optimized materials as a delivery vehicle. Polymers are proposed as suitable biomedical materials for several reasons. Firstly, both of hydrophobic conventional drugs and hydrophilic enzymes and proteins can be encapsulated according to polymer nature. Secondly, a wide range of chemical modification is applicable. The easy modification makes efficient delivery possible by controlling the release of cargo by disease-specific stimuli. Based on these advantages, inflammation-responsive polymeric carriers are introduced in here. In chapter 1, ROS-responsive polymeric degradation via chemical amplification is demonstrated. This polymer degraded 12 times faster compared with its control polymer by employing chemical amplification strategy. In chapter 2, anti-inflammatory drug conjugated polymer is introduced. To maximize drug delivery efficiency, an anti-inflammatory drug was conjugated onto dextran using a ROS-responsive linker. This polymeric material not only releases the anti-inflammatory drug in inflammatory cells but also increased drug efficacy by reducing ROS level in inflammation. In chapter 3, bioresponsive prophylaxis polymeric materials for acute inflammation is demonstrated both in vitro and in vivo.
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