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Design and Optimization of an Ultras...

Drazic, Jelena.

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Design and Optimization of an Ultrasound System for Two Photon Microscopy Studies of Ultrasound and Microbubble Assisted Blood-brain Barrier Disruption.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Design and Optimization of an Ultrasound System for Two Photon Microscopy Studies of Ultrasound and Microbubble Assisted Blood-brain Barrier Disruption./
Author:	Drazic, Jelena.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2011,
Description:	115 p.
Notes:	Source: Masters Abstracts International, Volume: 73-07.
Contained By:	Masters Abstracts International73-07.
Subject:	Biophysics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR76189
ISBN:	9780494761892

Design and Optimization of an Ultrasound System for Two Photon Microscopy Studies of Ultrasound and Microbubble Assisted Blood-brain Barrier Disruption.
Drazic, Jelena.

Design and Optimization of an Ultrasound System for Two Photon Microscopy Studies of Ultrasound and Microbubble Assisted Blood-brain Barrier Disruption. - Ann Arbor : ProQuest Dissertations & Theses, 2011 - 115 p.

Source: Masters Abstracts International, Volume: 73-07.

Thesis (M.Sc.)--University of Toronto (Canada), 2011.

This item must not be sold to any third party vendors.

In vivo real-time data of ultrasound and microbubble assisted blood-brain barrier disruption is centrally based on low-resolution magnetic resonance images. Additional information can be gained using online microscopic monitoring. This study presents the first ever in vivo two-photon microscopy, four-dimensional data sets of ultrasound and microbubble assisted blood-brain barrier disruption. It characterized the threshold pressures and mechanical index needed to disrupt the vasculature with 800 kHz ultrasound, and found three different leakage constants from the compromised vasculature. Furthermore, using numerical models, an ultrasound array was designed and optimized to perform specifically with our two-photon microscope. It was fabricated, fully characterized, and its performance met both the required pressure field profile and the pressure values needed for our in vivo two-photon microscopy experiments. This array is an important step in microscopically characterizing ultrasound and microbubble assisted blood-brain barrier disruption.

ISBN: 9780494761892Subjects--Topical Terms:

518360
Biophysics.
Subjects--Index Terms:

Blood-brain barrier disruption

Design and Optimization of an Ultrasound System for Two Photon Microscopy Studies of Ultrasound and Microbubble Assisted Blood-brain Barrier Disruption.
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506 $a This item must not be added to any third party search indexes.
520 $a In vivo real-time data of ultrasound and microbubble assisted blood-brain barrier disruption is centrally based on low-resolution magnetic resonance images. Additional information can be gained using online microscopic monitoring. This study presents the first ever in vivo two-photon microscopy, four-dimensional data sets of ultrasound and microbubble assisted blood-brain barrier disruption. It characterized the threshold pressures and mechanical index needed to disrupt the vasculature with 800 kHz ultrasound, and found three different leakage constants from the compromised vasculature. Furthermore, using numerical models, an ultrasound array was designed and optimized to perform specifically with our two-photon microscope. It was fabricated, fully characterized, and its performance met both the required pressure field profile and the pressure values needed for our in vivo two-photon microscopy experiments. This array is an important step in microscopically characterizing ultrasound and microbubble assisted blood-brain barrier disruption.
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