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The Regulation of Cd4 in T Cells: Li...

Ng, Charles.

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The Regulation of Cd4 in T Cells: Lineage Commitment and Heritable Silencing of Cd4 Expression in CD8 + Cytotoxic T Cells.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Regulation of Cd4 in T Cells: Lineage Commitment and Heritable Silencing of Cd4 Expression in CD8 + Cytotoxic T Cells./
作者:	Ng, Charles.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
面頁冊數:	126 p.
附註:	Source: Dissertations Abstracts International, Volume: 80-10, Section: B.
Contained By:	Dissertations Abstracts International80-10B.
標題:	Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13421001
ISBN:	9781392004609

The Regulation of Cd4 in T Cells: Lineage Commitment and Heritable Silencing of Cd4 Expression in CD8 + Cytotoxic T Cells.
Ng, Charles.

The Regulation of Cd4 in T Cells: Lineage Commitment and Heritable Silencing of Cd4 Expression in CD8 + Cytotoxic T Cells. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 126 p.

Source: Dissertations Abstracts International, Volume: 80-10, Section: B.

Thesis (Ph.D.)--New York University, 2019.

This item must not be sold to any third party vendors.

T cells are critical mediators of adaptive immunity. The two primary lineages of αβ T cells are marked by the MHC coreceptors CD4 and CD8, and they develop from a common bipotent precursor cell in the thymus that is CD8+CD4+ double-positive in a process referred to as lineage commitment. The T cell receptor (TCR) specificity for MHC class I and II invariably corresponds to the CD8+ and CD4 + lineages, respectively, despite the random rearrangement of gene segments encoding the TCR. An approach to obtain a molecular understanding of CD4/CD8 lineage commitment has been to study the regulation of the genes encoding CD4 and CD8. In this thesis, I focus on the regulation of the Cd4 gene, specifically the mechanisms involved in maintaining its repression in CD8+ T cells. This dissertation will focus on the role of the histone chaperone Chromatin Assembly Factor 1 (CAF-1) and its collaboration with the DNA methyltransferases in the heritable repression of Cd4. I also provide evidence for new functional roles of non-coding genomic regions at the Cd4 locus in maintaining expression states of CD4 in mature T cells. By elucidating mechanisms in which Cd4 is silenced in CD8+ T cells, we may gain insight into how cell identity is maintained and how the CD4 and CD8 lineages are established.

ISBN: 9781392004609Subjects--Topical Terms:

518431
Physiology.
Subjects--Index Terms:

Cd4

The Regulation of Cd4 in T Cells: Lineage Commitment and Heritable Silencing of Cd4 Expression in CD8 + Cytotoxic T Cells.
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520 $a T cells are critical mediators of adaptive immunity. The two primary lineages of αβ T cells are marked by the MHC coreceptors CD4 and CD8, and they develop from a common bipotent precursor cell in the thymus that is CD8+CD4+ double-positive in a process referred to as lineage commitment. The T cell receptor (TCR) specificity for MHC class I and II invariably corresponds to the CD8+ and CD4 + lineages, respectively, despite the random rearrangement of gene segments encoding the TCR. An approach to obtain a molecular understanding of CD4/CD8 lineage commitment has been to study the regulation of the genes encoding CD4 and CD8. In this thesis, I focus on the regulation of the Cd4 gene, specifically the mechanisms involved in maintaining its repression in CD8+ T cells. This dissertation will focus on the role of the histone chaperone Chromatin Assembly Factor 1 (CAF-1) and its collaboration with the DNA methyltransferases in the heritable repression of Cd4. I also provide evidence for new functional roles of non-coding genomic regions at the Cd4 locus in maintaining expression states of CD4 in mature T cells. By elucidating mechanisms in which Cd4 is silenced in CD8+ T cells, we may gain insight into how cell identity is maintained and how the CD4 and CD8 lineages are established.
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