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Role of Epithelial Cells in Detectio...

Luedke, Kory.

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Role of Epithelial Cells in Detection and Response to Sensory Stimuli in Drosophila.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Role of Epithelial Cells in Detection and Response to Sensory Stimuli in Drosophila./
作者:	Luedke, Kory.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
面頁冊數:	113 p.
附註:	Source: Dissertations Abstracts International, Volume: 81-11, Section: B.
Contained By:	Dissertations Abstracts International81-11B.
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27672575
ISBN:	9798641790022

Role of Epithelial Cells in Detection and Response to Sensory Stimuli in Drosophila.
Luedke, Kory.

Role of Epithelial Cells in Detection and Response to Sensory Stimuli in Drosophila. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 113 p.

Source: Dissertations Abstracts International, Volume: 81-11, Section: B.

Thesis (Ph.D.)--University of Washington, 2020.

This item must not be sold to any third party vendors.

Interactions between cell types plays an important role in shaping the morphology and function of those cells. One powerful example is in the peripheral nervous system, where sensory neurons coordinate with epidermal structures to help us sense the environment around us. However, there are many aspects of this sensory system that have only recently been investigated. First, this thesis reviews the current understanding of the mechanisms that guide, shape, and regulate the response to external stimuli in the epidermis. It describes our changing historical perspective on epithelial cells from simple physical support structures to active participants in the sensory apparatus. Second, we use the Drosophila peripheral nervous system as a model to identify novel regulators of neuron-epithelial interactions. We found that the microRNA miR-14 is required in the epithelium, where it likely regulates the expression of gap junctions, which ensure tight coupling between adjacent epithelial cells. This prevents precocious innervation of the neuron into the cell junction. Changes in dendrite morphology and innervation of the junction are highly correlated with changes in sensitivity of the nociceptive neuron.

ISBN: 9798641790022Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Drosophila

Role of Epithelial Cells in Detection and Response to Sensory Stimuli in Drosophila.
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506 $a This item must not be added to any third party search indexes.
520 $a Interactions between cell types plays an important role in shaping the morphology and function of those cells. One powerful example is in the peripheral nervous system, where sensory neurons coordinate with epidermal structures to help us sense the environment around us. However, there are many aspects of this sensory system that have only recently been investigated. First, this thesis reviews the current understanding of the mechanisms that guide, shape, and regulate the response to external stimuli in the epidermis. It describes our changing historical perspective on epithelial cells from simple physical support structures to active participants in the sensory apparatus. Second, we use the Drosophila peripheral nervous system as a model to identify novel regulators of neuron-epithelial interactions. We found that the microRNA miR-14 is required in the epithelium, where it likely regulates the expression of gap junctions, which ensure tight coupling between adjacent epithelial cells. This prevents precocious innervation of the neuron into the cell junction. Changes in dendrite morphology and innervation of the junction are highly correlated with changes in sensitivity of the nociceptive neuron.
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650 4 $a Developmental biology. $3 592588
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653 $a Nociception
653 $a Somatosensation
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