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Statistical Physics of Information P...

Wang, Ching-Hao.

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Statistical Physics of Information Processing by Cells.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Statistical Physics of Information Processing by Cells./
作者:	Wang, Ching-Hao.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
面頁冊數:	221 p.
附註:	Source: Dissertations Abstracts International, Volume: 81-02, Section: B.
Contained By:	Dissertations Abstracts International81-02B.
標題:	Biophysics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13421157
ISBN:	9781085588133

Statistical Physics of Information Processing by Cells.
Wang, Ching-Hao.

Statistical Physics of Information Processing by Cells. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 221 p.

Source: Dissertations Abstracts International, Volume: 81-02, Section: B.

Thesis (Ph.D.)--Boston University, 2019.

This item must not be sold to any third party vendors.

This thesis provides a physics account of the ability of cells to integrate environmental information to make complex decisions, a process commonly known as signaling. It strives to address the following questions: (i) How do cells relate the state of the environment (e.g. presence/absence of specific molecules) to a desired response such as gene expression? (ii) How can cells robustly transfer information? (iii) Is there a biophysical limit to a cells' ability to process information? (iv) Can we use the answers to the above questions to formulate biophysical principles that inform us about the evolution of signaling? Throughout, I borrow techniques from non-equilibrium statistical physics, statistical learning theory, information theory and information geometry to construct biophysical models capable of making quantitative experimental predictions. Finally, I address the connection of energy expenditure and biological efficiency by zeroing in on a process unique to eukaryotic cells-- nuclear transport. The thesis concludes with a discussion of our theory and its implications for synthetic biology.

ISBN: 9781085588133Subjects--Topical Terms:

518360
Biophysics.

Statistical Physics of Information Processing by Cells.
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