東華大學圖書館 |

Antibody glycosylation

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Antibody glycosylation/ edited by Marija Pezer.
其他作者:	Pezer, Marija.
出版者:	Cham :Springer International Publishing : : 2021.,
面頁冊數:	xii, 587 p. :ill. (some col.), digital ;24 cm.
內容註:	Microheterogeneity of antibody molecules -- Part I: Analytical Methods -- Lectin and LC based methods for immunoglobulin (G) glycosylation analysis -- Mass spectrometry-based methods for immunoglobulin G N-glycosylation analysis -- CE based methods for Ig(G) glycosylation analysis -- Automation of Ig glycosylation analysis -- Bioinformatics in immunoglobulin glycosylation analysis -- Part II: Biosynthesis & Regulation -- N-glycan biosynthesis: Basic principles and factors affecting its outcome -- Genetic regulation of immunoglobulin G glycosylation -- Epigenetics of immunoglobulin G glycosylation -- IgG changes in aging and other inflammatory conditions -- Estrogen-driven changes in immunoglobulin G Fc glycosylation -- Part III: Effector Functions & Diseases -- Sweet rules - linking glycosylation to antibody function -- Immunoglobulin G glycosylation in diseases -- Immunoglobulin A glycosylation and its role in diseases -- Part IV: Applications -- Importance and monitoring of therapeutic immunoglobulin G glycosylation -- Glycosylation of plant-produced immunoglobulins -- The rapidly expanding nexus of immunoglobulin G N-glycomics, suboptimal health status, and precision medicine -- Glycosylation of antigen-specific antibodies - Perspectives on immunoglobulin G glycosylation in vaccination and immunotherapy.
Contained By:	Springer Nature eBook
標題:	Immunoglobulin G. -
電子資源:	https://doi.org/10.1007/978-3-030-76912-3
ISBN:	9783030769123

Antibody glycosylation
Antibody glycosylation[electronic resource] /edited by Marija Pezer. - Cham :Springer International Publishing :2021. - xii, 587 p. :ill. (some col.), digital ;24 cm. - Experientia supplementum,v. 1122504-3692 ;. - Experientia supplementum ;v. 112..

Microheterogeneity of antibody molecules -- Part I: Analytical Methods -- Lectin and LC based methods for immunoglobulin (G) glycosylation analysis -- Mass spectrometry-based methods for immunoglobulin G N-glycosylation analysis -- CE based methods for Ig(G) glycosylation analysis -- Automation of Ig glycosylation analysis -- Bioinformatics in immunoglobulin glycosylation analysis -- Part II: Biosynthesis & Regulation -- N-glycan biosynthesis: Basic principles and factors affecting its outcome -- Genetic regulation of immunoglobulin G glycosylation -- Epigenetics of immunoglobulin G glycosylation -- IgG changes in aging and other inflammatory conditions -- Estrogen-driven changes in immunoglobulin G Fc glycosylation -- Part III: Effector Functions & Diseases -- Sweet rules - linking glycosylation to antibody function -- Immunoglobulin G glycosylation in diseases -- Immunoglobulin A glycosylation and its role in diseases -- Part IV: Applications -- Importance and monitoring of therapeutic immunoglobulin G glycosylation -- Glycosylation of plant-produced immunoglobulins -- The rapidly expanding nexus of immunoglobulin G N-glycomics, suboptimal health status, and precision medicine -- Glycosylation of antigen-specific antibodies - Perspectives on immunoglobulin G glycosylation in vaccination and immunotherapy.

This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

ISBN: 9783030769123

Standard No.: 10.1007/978-3-030-76912-3doiSubjects--Topical Terms:

3201229
Immunoglobulin G.

LC Class. No.: QR186.8.G2

Dewey Class. No.: 571.967

Antibody glycosylation
LDR:04183nmm a2200337 a 4500 001 2253379
003 DE-He213
005 20211022221926.0
006 m d
007 cr nn 008maaau
008 220327s2021 sz s 0 eng d
020 $a 9783030769123 $q (electronic bk.)
020 $a 9783030769116 $q (paper)
024 7 $a 10.1007/978-3-030-76912-3 $2 doi
035 $a 978-3-030-76912-3
040 $a GP $c GP
041 0 $a eng
050 4 $a QR186.8.G2
072 7 $a MJCM $2 bicssc
072 7 $a MED044000 $2 bisacsh
072 7 $a MJCM $2 thema
082 0 4 $a 571.967 $2 23
090 $a QR186.8.G2 $b A629 2021
245 0 0 $a Antibody glycosylation $h [electronic resource] / $c edited by Marija Pezer.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2021.
300 $a xii, 587 p. : $b ill. (some col.), digital ; $c 24 cm.
490 1 $a Experientia supplementum, $x 2504-3692 ; $v v. 112
505 0 $a Microheterogeneity of antibody molecules -- Part I: Analytical Methods -- Lectin and LC based methods for immunoglobulin (G) glycosylation analysis -- Mass spectrometry-based methods for immunoglobulin G N-glycosylation analysis -- CE based methods for Ig(G) glycosylation analysis -- Automation of Ig glycosylation analysis -- Bioinformatics in immunoglobulin glycosylation analysis -- Part II: Biosynthesis & Regulation -- N-glycan biosynthesis: Basic principles and factors affecting its outcome -- Genetic regulation of immunoglobulin G glycosylation -- Epigenetics of immunoglobulin G glycosylation -- IgG changes in aging and other inflammatory conditions -- Estrogen-driven changes in immunoglobulin G Fc glycosylation -- Part III: Effector Functions & Diseases -- Sweet rules - linking glycosylation to antibody function -- Immunoglobulin G glycosylation in diseases -- Immunoglobulin A glycosylation and its role in diseases -- Part IV: Applications -- Importance and monitoring of therapeutic immunoglobulin G glycosylation -- Glycosylation of plant-produced immunoglobulins -- The rapidly expanding nexus of immunoglobulin G N-glycomics, suboptimal health status, and precision medicine -- Glycosylation of antigen-specific antibodies - Perspectives on immunoglobulin G glycosylation in vaccination and immunotherapy.
520 $a This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
650 0 $a Immunoglobulin G. $3 3201229
650 0 $a Glycosylation. $3 871799
650 1 4 $a Immunology. $3 611031
650 2 4 $a Pharmacology/Toxicology. $3 890953
650 2 4 $a Biomedicine, general. $3 3446035
650 2 4 $a Analytical Chemistry. $3 890839
650 2 4 $a Biotechnology. $3 571461
700 1 $a Pezer, Marija. $3 3521542
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer Nature eBook
830 0 $a Experientia supplementum ; $v v. 112. $3 3521543
856 4 0 $u https://doi.org/10.1007/978-3-030-76912-3
950 $a Biomedical and Life Sciences (SpringerNature-11642)