東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Clinical epigenetics

Hesson, Luke B.

FindBook

Google Book

Amazon

博客來

Clinical epigenetics

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Clinical epigenetics/ edited by Luke B. Hesson, Antonia L. Pritchard.
其他作者:	Hesson, Luke B.
出版者:	Singapore :Springer Singapore : : 2019.,
面頁冊數:	xi, 265 p. :ill. (some col.), digital ;24 cm.
內容註:	Genetics and epigenetics: a Historical Overview -- The DNA methylation machinery -- Methylcytosine and its oxidised derivatives -- The role of nucleosomes in epigenetic gene regulation -- Circular RNAs in human health and disease -- The role of histone variants in cancer -- DNA methylation and carcinogenesis: Current and future perspectives -- Dysregulation of cis-regulatory elements in cancer -- Germline epigenetic testing of imprinting disorders in a diagnostic setting -- Cancer methylation biomarkers in circulating cell-free DNA -- The clinical utility of epigenetics.
Contained By:	Springer Nature eBook
標題:	Epigenetics. -
電子資源:	https://doi.org/10.1007/978-981-13-8958-0
ISBN:	9789811389580

Clinical epigenetics
Clinical epigenetics[electronic resource] /edited by Luke B. Hesson, Antonia L. Pritchard. - Singapore :Springer Singapore :2019. - xi, 265 p. :ill. (some col.), digital ;24 cm.

Genetics and epigenetics: a Historical Overview -- The DNA methylation machinery -- Methylcytosine and its oxidised derivatives -- The role of nucleosomes in epigenetic gene regulation -- Circular RNAs in human health and disease -- The role of histone variants in cancer -- DNA methylation and carcinogenesis: Current and future perspectives -- Dysregulation of cis-regulatory elements in cancer -- Germline epigenetic testing of imprinting disorders in a diagnostic setting -- Cancer methylation biomarkers in circulating cell-free DNA -- The clinical utility of epigenetics.

In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories. The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing.

ISBN: 9789811389580

Standard No.: 10.1007/978-981-13-8958-0doiSubjects--Topical Terms:

1568224
Epigenetics.

LC Class. No.: RB155 / .C556 2019

Dewey Class. No.: 616.042

Clinical epigenetics
LDR:02894nmm a2200325 a 4500 001 2242539
003 DE-He213
005 20200903150053.0
006 m d
007 cr nn 008maaau
008 211207s2019 si s 0 eng d
020 $a 9789811389580 $q (electronic bk.)
020 $a 9789811389573 $q (paper)
024 7 $a 10.1007/978-981-13-8958-0 $2 doi
035 $a 978-981-13-8958-0
040 $a GP $c GP
041 0 $a eng
050 4 $a RB155 $b .C556 2019
072 7 $a MFN $2 bicssc
072 7 $a MED107000 $2 bisacsh
072 7 $a MFN $2 thema
082 0 4 $a 616.042 $2 23
090 $a RB155 $b .C641 2019
245 0 0 $a Clinical epigenetics $h [electronic resource] / $c edited by Luke B. Hesson, Antonia L. Pritchard.
260 $a Singapore : $b Springer Singapore : $b Imprint: Springer, $c 2019.
300 $a xi, 265 p. : $b ill. (some col.), digital ; $c 24 cm.
505 0 $a Genetics and epigenetics: a Historical Overview -- The DNA methylation machinery -- Methylcytosine and its oxidised derivatives -- The role of nucleosomes in epigenetic gene regulation -- Circular RNAs in human health and disease -- The role of histone variants in cancer -- DNA methylation and carcinogenesis: Current and future perspectives -- Dysregulation of cis-regulatory elements in cancer -- Germline epigenetic testing of imprinting disorders in a diagnostic setting -- Cancer methylation biomarkers in circulating cell-free DNA -- The clinical utility of epigenetics.
520 $a In genetic pathology, epigenetic testing is rare and under utilised. In this book, we introduce epigenetics to a non-expert scientific audience and describe current and future clinical utility of epigenetic testing. By focussing on epigenetics in human disease this book will guide professionals (scientists and clinicians) to understand how epigenetics is relevant in a clinical context, and to implement epigenetic testing in diagnostic laboratories. The book begins with a historical perspective of genetics and epigenetics and describes the work of pioneers who have helped shape these fields. The various mechanisms by which epigenetics can regulate the function of the genome is described. These include DNA methylation, histone modifications, histone variants, nucleosome positioning, cis-regulatory elements, non-coding RNAs and the three-dimensional organisation of chromatin in the nucleus. These are discussed in the context of embryological development, cancer and imprinting disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic testing in a diagnostic setting, the book includes a case study that illustrates the clinical utility of epigenetic testing.
650 0 $a Epigenetics. $3 1568224
650 0 $a Medical genetics. $3 651823
650 1 4 $a Gene Expression. $3 600530
650 2 4 $a Gene Function. $3 1067308
650 2 4 $a Gene Therapy. $3 600618
650 2 4 $a Cytogenetics. $3 664496
650 2 4 $a Molecular Medicine. $3 890952
700 1 $a Hesson, Luke B. $3 3501814
700 1 $a Pritchard, Antonia L. $3 3501815
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer Nature eBook
856 4 0 $u https://doi.org/10.1007/978-981-13-8958-0
950 $a Biomedical and Life Sciences (SpringerNature-11642)