Prodrug design = perspectives, appro...
Redasani, Vivekkumar K.,

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  • Prodrug design = perspectives, approaches and applications in medicinal chemistry /
  • 紀錄類型: 書目-電子資源 : Monograph/item
    正題名/作者: Prodrug design/ Vivekkumar K. Redasani, Sanjay B. Bari.
    其他題名: perspectives, approaches and applications in medicinal chemistry /
    作者: Redasani, Vivekkumar K.,
    其他作者: Bari, Sanjay B.,
    出版者: [Amsterdam] :Academic Press is an imprint of Elsevier, : 2015.,
    面頁冊數: 1 online resource.
    內容註: Front Cover; Prodrug Design; Copyright Page; Dedication; Contents; Preface; 1 Introduction; 1.1 Background; 1.2 Drug Development; 1.3 The Drug Discovery Process; 1.3.1 Goal of Drug Discovery; 1.3.2 Constraints in Drug Discovery; 1.4 Current Scenario in Prodrug Research; 1.5 Need of the Study; References; 2 Concept of Prodrug; 2.1 Concept of Prodrug; 2.2 Undesirable Properties Associated with Drug Molecules; 2.3 Prodrug Design: Past to Present; 2.4 Definitions of Prodrug; 2.5 Rationale for the Use of Prodrugs; 2.6 Targeted Prodrug Design; 2.7 Double Prodrug Concept; 2.8 Steps in Prodrug Design.
    內容註: 2.8.1 Hard Drugs2.8.2 Soft Drugs; 2.9 Objectives in Prodrug Research; 2.9.1 Pharmaceutical Objectives; 2.9.2 Pharmacokinetic Objectives; 2.9.3 Pharmacodynamic Objectives; 2.10 Evaluation of Prodrugs; 2.10.1 Physiochemical Parameters; 2.10.2 Pharmacokinetics Profile; 2.10.3 Pharmacodynamics; References; 3 Types of Prodrugs; 3.1 Classification of Prodrugs; 3.1.1 Research-Related Criteria; 3.1.2 Chemical Criteria; 3.1.2.1 Carrier-Linked Prodrug; 3.1.2.2 Mutual Prodrug; 3.1.2.3 Bioprecursor Prodrug; 3.1.2.3.1 Oxidative Bioactivations; 3.1.2.3.2 Reductive Bioactivations; 3.1.2.4 Polymeric Prodrug.
    內容註: 3.1.2.5 Tripartate Prodrug3.2 Criteria for Prodrug; 3.3 Classifying Prodrugs; 3.4 Challenges and Limitations in Prodrug Design; References; 4 Approaches for Prodrugs; 4.1 Promoiety; 4.2 Functional Groups Compliant for Design of Prodrug; 4.3 Bioreversible Derivatives for Various Functional Groups; 4.4 Phosphate Esters as Prodrugs of Hydroxyl or Amine Functionalities; 4.5 Amides as Prodrugs of Carboxylic Acids and Amines; 4.6 Prodrug for Amides, Imides, and Other Acidic Compounds; 4.6.1 N-Mannich Bases and Acyloxy Derivatives; 4.6.2 N-Acyl Derivatives; 4.6.3 N-Hydroxy Methyl Derivatives.
    內容註: 4.7 Prodrugs for Amines4.7.1 N-(Acyloxy Alkoxy Carbonyl) Derivatives and Amide Derivatives; 4.7.2 Oxazolidines; 4.8 Prodrugs with Carbonyl groups; 4.8.1 Thiazolidines; 4.8.2 Enol Esters; 4.9 Types of Promoieties Used in Designing of Prodrugs; 4.9.1 Amino Acids; 4.9.2 Polysaccharides; 4.9.3 Alcohols; 4.9.4 Phytophenols; 4.9.5 Amines; 4.9.6 Polymers; 4.9.6.1 Requirements for Selecting Polymers as Candidate Drug Carriers; 4.9.6.2 Classification of Polymers Used for Bioconjugation; 4.10 Coupling of Drug and Polymer Through Spacers; References; 5 Applications; 5.1 Applications of Prodrug Designing.
    內容註: 5.1.1 Masking Taste and Odor5.1.2 Minimizing Pain at Injection Site; 5.1.3 Alteration of Drug Solubility; 5.1.4 Enhancement of Chemical Stability; 5.1.5 Prodrugs to Overcome Absorption Problems; 5.1.5.1 Enhancement of Oral Absorption; 5.1.5.2 Enhancement of Ophthalmic Absorption; 5.1.5.3 Enhancement of Percutaneous Absorption; 5.1.6 Prevention of Presystemic Metabolism; 5.1.7 Longer Duration of Action; 5.1.8 To Diminish Local and Systemic Toxicity of Drugs/Reduction of GI Irritability; 5.1.9 Site-Specific Drug Delivery; 5.1.10 Prodrug for Slow and Prolonged Release (Sustained Drug Action).
    標題: Pharmaceutical chemistry. -
    電子資源: https://www.sciencedirect.com/science/book/9780128035191
    ISBN: 9780128035573 (electronic bk.)
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