東華大學圖書館 |

Clinical research transformed

Record Type:	Electronic resources : Monograph/item
Title/Author:	Clinical research transformed/ by Olli S. Miettinen, Johann Steurer, Albert Hofman.
Author:	Miettinen, Olli S.
other author:	Steurer, Johann.
Published:	Cham :Springer International Publishing : : 2019.,
Description:	xxiv, 302 p. :ill., digital ;24 cm.
[NT 15003449]:	Foreword -- Preface -- Acknowledgements -- Essence of Clinical Medicine -- Essence of Clinical Research -- Clinical Research and Clinical Medicine at present -- Clinical Research Transformative of Clinical Medicine -- Core Concepts of Epidemiology and Epidemiological Research -- The Epidemiological Interface of Gnostic Clinical Research -- The Logistic Regression Model -- Statistics from the Model's Fitting to Gnostic Data -- The Types of Diagnostic Challenge and Needs for Knowledge -- Harvesting Experts' Diagnostic Probability Estimates -- Objects Design for a Diagnostic Probability Study -- Methods Design for a Diagnostic Probability Study -- The Bayes' Theorem Framework for Diagnostic Research -- Research Focused on Diagnostic Tests -- Introduction to Etiognostic Research -- Objects Design for an Etiognostic Study -- Methods Design for an Etiognostic Study -- Introduction to Prognostic Research -- Example: Research on 'Hormone Replacement Therapy' -- Prognostic Probability Functions from Clinical-trial Data -- Non-experimental Intervention-prognostic Studies -- Intervention-prognostic Derivative Research -- Theory of Medicine Defining the Essential Missions for Clinical Research -- Theory of Clinical Research for Its Essential - Gnosis-serving - Missions -- Toward Worldwide Scientific Clinical Medicine -- Glossary -- Appendix 1: What about 'Machine Learning'?- Appendix 2: On Excellence of Epidemiologic Academia -- Index.
Contained By:	Springer eBooks
Subject:	Clinical medicine - Research. -
Online resource:	https://doi.org/10.1007/978-3-030-06176-0
ISBN:	9783030061760

Clinical research transformed
Miettinen, Olli S.

Clinical research transformed[electronic resource] /by Olli S. Miettinen, Johann Steurer, Albert Hofman. - Cham :Springer International Publishing :2019. - xxiv, 302 p. :ill., digital ;24 cm.

Foreword -- Preface -- Acknowledgements -- Essence of Clinical Medicine -- Essence of Clinical Research -- Clinical Research and Clinical Medicine at present -- Clinical Research Transformative of Clinical Medicine -- Core Concepts of Epidemiology and Epidemiological Research -- The Epidemiological Interface of Gnostic Clinical Research -- The Logistic Regression Model -- Statistics from the Model's Fitting to Gnostic Data -- The Types of Diagnostic Challenge and Needs for Knowledge -- Harvesting Experts' Diagnostic Probability Estimates -- Objects Design for a Diagnostic Probability Study -- Methods Design for a Diagnostic Probability Study -- The Bayes' Theorem Framework for Diagnostic Research -- Research Focused on Diagnostic Tests -- Introduction to Etiognostic Research -- Objects Design for an Etiognostic Study -- Methods Design for an Etiognostic Study -- Introduction to Prognostic Research -- Example: Research on 'Hormone Replacement Therapy' -- Prognostic Probability Functions from Clinical-trial Data -- Non-experimental Intervention-prognostic Studies -- Intervention-prognostic Derivative Research -- Theory of Medicine Defining the Essential Missions for Clinical Research -- Theory of Clinical Research for Its Essential - Gnosis-serving - Missions -- Toward Worldwide Scientific Clinical Medicine -- Glossary -- Appendix 1: What about 'Machine Learning'?- Appendix 2: On Excellence of Epidemiologic Academia -- Index.

This book delineates the fundamental transformations that, according to its precepts, are now needed in the objects and methods of 'patient-oriented' clinical research, in order to make it genuinely patient-relevant. These transformations are presented as providing for transition from today's 'evidence-based' practices (advocated by 'clinical epidemiologists') to knowledge-based succedanea of these. While those existing practices vary according to doctors' personal opinions about the burden of the available evidence, their knowledge-based succedanea will be essentially invariant across individual doctors, as they'll be guided by 'expert systems' (imbedded in cyberspace) At issue in this is transformation in what the authors present as the very essence of clinical medicine, namely clinical doctors' esoteric ad-hoc knowing: "gnosis." This is clinical doctors' knowing - probabilistic - about relevant-but-hidden truths about their patients' health, and constitutes the basis for their teaching ("doctoring") the patients about these esoteric insights. The probabilities are 'personalized' in the meaning of their specificity to the cases' gnostic profiles. Genuinely patient-relevant clinical knowledge this book presents as the requisite basis for three species of clinical doctors' gnosis: diagnosis - knowing about whether a particular type of illness is present (though hidden) in the patient; etiognosis - knowing about whether the patient's illness was caused by a particular antecedent of it; and prognosis - knowing about the patient's future health, including as to its dependence on the choice of treatment. Pivotal in gnostic clinical research this book presents to be the studies' objects design in terms of a statistical model for the rate of occurrence of the entity of health in question, in a defined domain of case presentations. The essentials of the studies' methods designs are deduced from their objects designs. Study of this book - on the theory of "meta-epidemiological clinical research" - is essential preparation for teaching 'patient-oriented' clinical research and for actual design & conduct of the studies and of their critical reviews. And by the same token, study of this book is essential preparation for the needed replacement of 'case-based learning' of clinical medicine, for suitably-learned teaching of the practice of clinical medicine - focused on the status quo of the scientific knowledge-base for (gnoses in) the discipline ('specialty') at issue.

ISBN: 9783030061760

Standard No.: 10.1007/978-3-030-06176-0doiSubjects--Topical Terms:

822030
Clinical medicine
--Research.

LC Class. No.: R850 / .M548 2019

Dewey Class. No.: 610.72

Clinical research transformed
LDR:04928nmm a2200325 a 4500 001 2218707
003 DE-He213
005 20200117092656.0
006 m d
007 cr nn 008maaau
008 201126s2019 sz s 0 eng d
020 $a 9783030061760 $q (electronic bk.)
020 $a 9783030061753 $q (paper)
024 7 $a 10.1007/978-3-030-06176-0 $2 doi
035 $a 978-3-030-06176-0
040 $a GP $c GP
041 0 $a eng
050 4 $a R850 $b .M548 2019
072 7 $a MBGR $2 bicssc
072 7 $a MED000000 $2 bisacsh
072 7 $a MBGR $2 thema
082 0 4 $a 610.72 $2 23
090 $a R850 $b .M632 2019
100 1 $a Miettinen, Olli S. $q (Olli Sakari) $3 2160028
245 1 0 $a Clinical research transformed $h [electronic resource] / $c by Olli S. Miettinen, Johann Steurer, Albert Hofman.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2019.
300 $a xxiv, 302 p. : $b ill., digital ; $c 24 cm.
505 0 $a Foreword -- Preface -- Acknowledgements -- Essence of Clinical Medicine -- Essence of Clinical Research -- Clinical Research and Clinical Medicine at present -- Clinical Research Transformative of Clinical Medicine -- Core Concepts of Epidemiology and Epidemiological Research -- The Epidemiological Interface of Gnostic Clinical Research -- The Logistic Regression Model -- Statistics from the Model's Fitting to Gnostic Data -- The Types of Diagnostic Challenge and Needs for Knowledge -- Harvesting Experts' Diagnostic Probability Estimates -- Objects Design for a Diagnostic Probability Study -- Methods Design for a Diagnostic Probability Study -- The Bayes' Theorem Framework for Diagnostic Research -- Research Focused on Diagnostic Tests -- Introduction to Etiognostic Research -- Objects Design for an Etiognostic Study -- Methods Design for an Etiognostic Study -- Introduction to Prognostic Research -- Example: Research on 'Hormone Replacement Therapy' -- Prognostic Probability Functions from Clinical-trial Data -- Non-experimental Intervention-prognostic Studies -- Intervention-prognostic Derivative Research -- Theory of Medicine Defining the Essential Missions for Clinical Research -- Theory of Clinical Research for Its Essential - Gnosis-serving - Missions -- Toward Worldwide Scientific Clinical Medicine -- Glossary -- Appendix 1: What about 'Machine Learning'?- Appendix 2: On Excellence of Epidemiologic Academia -- Index.
520 $a This book delineates the fundamental transformations that, according to its precepts, are now needed in the objects and methods of 'patient-oriented' clinical research, in order to make it genuinely patient-relevant. These transformations are presented as providing for transition from today's 'evidence-based' practices (advocated by 'clinical epidemiologists') to knowledge-based succedanea of these. While those existing practices vary according to doctors' personal opinions about the burden of the available evidence, their knowledge-based succedanea will be essentially invariant across individual doctors, as they'll be guided by 'expert systems' (imbedded in cyberspace) At issue in this is transformation in what the authors present as the very essence of clinical medicine, namely clinical doctors' esoteric ad-hoc knowing: "gnosis." This is clinical doctors' knowing - probabilistic - about relevant-but-hidden truths about their patients' health, and constitutes the basis for their teaching ("doctoring") the patients about these esoteric insights. The probabilities are 'personalized' in the meaning of their specificity to the cases' gnostic profiles. Genuinely patient-relevant clinical knowledge this book presents as the requisite basis for three species of clinical doctors' gnosis: diagnosis - knowing about whether a particular type of illness is present (though hidden) in the patient; etiognosis - knowing about whether the patient's illness was caused by a particular antecedent of it; and prognosis - knowing about the patient's future health, including as to its dependence on the choice of treatment. Pivotal in gnostic clinical research this book presents to be the studies' objects design in terms of a statistical model for the rate of occurrence of the entity of health in question, in a defined domain of case presentations. The essentials of the studies' methods designs are deduced from their objects designs. Study of this book - on the theory of "meta-epidemiological clinical research" - is essential preparation for teaching 'patient-oriented' clinical research and for actual design & conduct of the studies and of their critical reviews. And by the same token, study of this book is essential preparation for the needed replacement of 'case-based learning' of clinical medicine, for suitably-learned teaching of the practice of clinical medicine - focused on the status quo of the scientific knowledge-base for (gnoses in) the discipline ('specialty') at issue.
650 0 $a Clinical medicine $x Research. $3 822030
650 1 4 $a Biomedicine, general. $3 3446035
650 2 4 $a Epidemiology. $3 568544
650 2 4 $a Public Health. $3 624351
650 2 4 $a Biostatistics. $3 1002712
650 2 4 $a Statistics for Life Sciences, Medicine, Health Sciences. $3 891086
650 2 4 $a Artificial Intelligence. $3 769149
700 1 $a Steurer, Johann. $3 3453288
700 1 $a Hofman, Albert. $3 3453289
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
856 4 0 $u https://doi.org/10.1007/978-3-030-06176-0
950 $a Biomedical and Life Sciences (Springer-11642)