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Comprehensive Characterization of th...

Mai, Wilson Xuan.

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Comprehensive Characterization of the Apoptotic Machinery in Glioblastoma Identifies New Therapeutic Strategies.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Comprehensive Characterization of the Apoptotic Machinery in Glioblastoma Identifies New Therapeutic Strategies./
作者:	Mai, Wilson Xuan.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	125 p.
附註:	Source: Dissertations Abstracts International, Volume: 79-12, Section: B.
Contained By:	Dissertations Abstracts International79-12B.
標題:	Molecular biology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10809335
ISBN:	9780355939897

Comprehensive Characterization of the Apoptotic Machinery in Glioblastoma Identifies New Therapeutic Strategies.
Mai, Wilson Xuan.

Comprehensive Characterization of the Apoptotic Machinery in Glioblastoma Identifies New Therapeutic Strategies. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 125 p.

Source: Dissertations Abstracts International, Volume: 79-12, Section: B.

Thesis (Ph.D.)--University of California, Los Angeles, 2018.

This item must not be sold to any third party vendors.

Effective treatments for cancer require the engagement of the apoptotic (cell death) machinery. These pathways have been implicated in the therapeutic efficacy of almost every chemotherapy, targeted agent, and even in some forms of immunotherapy. Inability to sufficiently engage the apoptotic machinery results in tumor survival and resistance. Glioblastoma (GBM), the deadliest form of brain cancer, has poor clinical response to almost every therapy, suggesting a heightened anti-apoptotic signature. In these studies, we are the first to comprehensively characterize the apoptotic machinery in patient-derived GBM samples through genetic, molecular, and functional measures. In the first portion of this work, we demonstrate how GBM are capable of utilizing multiple apoptotic blocks and how this versatility endows them with intrinsic resistance to standard of care. By understanding the intricacies in GBM apoptotic machinery, we are able to rationally design therapeutic strategies to exploit these dependencies, as highlighted by the second portion of this work.

ISBN: 9780355939897Subjects--Topical Terms:

517296
Molecular biology.

Comprehensive Characterization of the Apoptotic Machinery in Glioblastoma Identifies New Therapeutic Strategies.
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