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Intravenous Stromal Cell Therapy for...

Badner, Anna.

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Intravenous Stromal Cell Therapy for Vascular Protection following Traumatic Spinal Cord Injury.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Intravenous Stromal Cell Therapy for Vascular Protection following Traumatic Spinal Cord Injury./
作者:	Badner, Anna.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	211 p.
附註:	Source: Dissertations Abstracts International, Volume: 80-02, Section: B.
Contained By:	Dissertations Abstracts International80-02B.
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10792363
ISBN:	9780438188464

Intravenous Stromal Cell Therapy for Vascular Protection following Traumatic Spinal Cord Injury.
Badner, Anna.

Intravenous Stromal Cell Therapy for Vascular Protection following Traumatic Spinal Cord Injury. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 211 p.

Source: Dissertations Abstracts International, Volume: 80-02, Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2018.

This item must not be sold to any third party vendors.

Traumatic spinal cord injury (SCI) results in devastating chronic impairment and disability. Although there have been many advances in medical management and patient quality of life, a greater understanding of injury pathophysiology will help to tailor treatment options as well as identify novel strategies. Specifically, as mesenchymal stromal cells (MSCs) offer an ethically-sourced, abundant cell type for autologous use, they may be well-suited for SCI. Therefore, this thesis aimed to evaluate the intravenous application of human umbilical cord matrix-derived stromal cells for SCI, comparing the efficacy to that of brain-derived pericytes. Considering the developmental affiliation between MSCs and pericytes, this offers insights to tissue-specific differences in cell function. Further, as the cell therapy effects were linked to the production of interleukin-10 (IL-10) and splenic localization, these components were independently assessed in the context of SCI pathophysiology. While IL-10 deficiency was found to exacerbate acute vascular damage and long-term recovery, the spleen was minimally involved. Nevertheless, the spleen was found to be important in several key stromal cell-mediated effects post-SCI. Together, this work demonstrates that intravenous stromal cell infusion may be a suitable treatment paradigm for acute traumatic SCI, with effects mediated through a rise in systemic and splenic IL-10. Most importantly, it highlights that targeting aspects of the peripheral inflammatory response can translate to changes in the spinal cord.

ISBN: 9780438188464Subjects--Topical Terms:

588700
Neurosciences.

Intravenous Stromal Cell Therapy for Vascular Protection following Traumatic Spinal Cord Injury.
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