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Optical Spectroscopy for Breast Canc...

Walter, Eleanor Jane.

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Optical Spectroscopy for Breast Cancer Risk Screening.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Optical Spectroscopy for Breast Cancer Risk Screening./
Author:	Walter, Eleanor Jane.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	169 p.
Notes:	Source: Dissertations Abstracts International, Volume: 80-02, Section: B.
Contained By:	Dissertations Abstracts International80-02B.
Subject:	Medicine. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10784286
ISBN:	9780438190047

Optical Spectroscopy for Breast Cancer Risk Screening.
Walter, Eleanor Jane.

Optical Spectroscopy for Breast Cancer Risk Screening. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 169 p.

Source: Dissertations Abstracts International, Volume: 80-02, Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2018.

This item is not available from ProQuest Dissertations & Theses.

Breast cancer (BC) has the highest mortality rate among women's cancers worldwide, and incidence rates are rising in low- and middle-income countries (LMIC). Screening programs are well-established in most high-income countries, but there is much debate about screening frequency and the optimal screening ages. In LMIC screening infrastructure is insufficient. Optical spectroscopy (OS) can be used as a pre-screening technique to measure breast composition and predict mammographic density (MBD), a known BC risk factor. The goal of this thesis was to develop and evaluate an OS device which is portable, low cost and requires minimal operator interaction. The device was based on a research prototype used in previous studies, with two major changes: (1) a 13-laser-wavelength module replaced the broadband light source and (2) the source and detector positions were fixed within rigid holders of different sizes. The wavelengths critical for distinguishing between BC risk groups were selected using a principal components analysis of data from previous studies. Source and detector positions were chosen to match the optically-interrogated volumes of the original device via Monte Carlo simulations of photon propagation. Two versions were developed - one for women (the Cups device) and one for girls (the LEGACY device). The Cups device was evaluated in comparison with the research prototype on its ability to predict MBD. For both devices, women with high MBD could be identified from spectra with high sensitivity and specificity and correlation between mammographic percent density (MPD) and OS-predicted MPD was significant, although slightly weaker for the Cups device (r = 0.62 vs. r = 0.74). For girls, OS had been used as an objective method for distinguishing between breast development stages. Spectral analysis using only the wavelengths from the LEGACY device showed that the reduced spectral content does not affect the ability to distinguish between development stages.

ISBN: 9780438190047Subjects--Topical Terms:

641104
Medicine.

Optical Spectroscopy for Breast Cancer Risk Screening.
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506 $a This item must not be sold to any third party vendors.
520 $a Breast cancer (BC) has the highest mortality rate among women's cancers worldwide, and incidence rates are rising in low- and middle-income countries (LMIC). Screening programs are well-established in most high-income countries, but there is much debate about screening frequency and the optimal screening ages. In LMIC screening infrastructure is insufficient. Optical spectroscopy (OS) can be used as a pre-screening technique to measure breast composition and predict mammographic density (MBD), a known BC risk factor. The goal of this thesis was to develop and evaluate an OS device which is portable, low cost and requires minimal operator interaction. The device was based on a research prototype used in previous studies, with two major changes: (1) a 13-laser-wavelength module replaced the broadband light source and (2) the source and detector positions were fixed within rigid holders of different sizes. The wavelengths critical for distinguishing between BC risk groups were selected using a principal components analysis of data from previous studies. Source and detector positions were chosen to match the optically-interrogated volumes of the original device via Monte Carlo simulations of photon propagation. Two versions were developed - one for women (the Cups device) and one for girls (the LEGACY device). The Cups device was evaluated in comparison with the research prototype on its ability to predict MBD. For both devices, women with high MBD could be identified from spectra with high sensitivity and specificity and correlation between mammographic percent density (MPD) and OS-predicted MPD was significant, although slightly weaker for the Cups device (r = 0.62 vs. r = 0.74). For girls, OS had been used as an objective method for distinguishing between breast development stages. Spectral analysis using only the wavelengths from the LEGACY device showed that the reduced spectral content does not affect the ability to distinguish between development stages.
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