語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Prolonging and Boosting NMR Signals ...
~
Zhou, Zijian.
FindBook
Google Book
Amazon
博客來
Prolonging and Boosting NMR Signals with Long-lived States and Catalytic Polarization Transfer.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Prolonging and Boosting NMR Signals with Long-lived States and Catalytic Polarization Transfer./
作者:
Zhou, Zijian.
出版者:
Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:
212 p.
附註:
Source: Dissertations Abstracts International, Volume: 79-11, Section: B.
Contained By:
Dissertations Abstracts International79-11B.
標題:
Physical chemistry. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10751006
ISBN:
9780355907995
Prolonging and Boosting NMR Signals with Long-lived States and Catalytic Polarization Transfer.
Zhou, Zijian.
Prolonging and Boosting NMR Signals with Long-lived States and Catalytic Polarization Transfer.
- Ann Arbor : ProQuest Dissertations & Theses, 2018 - 212 p.
Source: Dissertations Abstracts International, Volume: 79-11, Section: B.
Thesis (Ph.D.)--Duke University, 2018.
This item is not available from ProQuest Dissertations & Theses.
Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are powerful and versatile tools that are being broadly and intensively used. Their application ranges from molecular structure determination to medical imaging diagnosis. Though NMR and MRI have great advantages such as high chemical environment sensitivity and non-invasive imaging ability with deep penetration, current magnetic resonance (MR) methodologies have fundamental limitations: they mainly use proton as signal source and provide primarily structural information. There are great challenges using MR to obtain metabolic information: for the life supporting elements carbon and nitrogen, their MR non-silent isotopes are in extremely low concentration and the signal they yield is extremely weak under thermal conditions. In addition, their short-lived signal gives us very limited time window to perform complicated experiments. Thus, it is of great significance to obtain long-lived and enhanced NMR and MRI signals for 13C and 15N. Doing so would not only augment information for in vitro chemical analysis, but also make it possible for metabolism monitoring, disease early diagnosis and treatment assessment. This dissertation will first show how we can make the signals long-lived using molecules with specific structures and sophisticated NMR pulses. Then, based on the concept of the long-lived state, it will demonstrate how we can obtain both enhanced and long-lived signals for 13C and 15N spin-pairs with the development of a novel hyperpolarization technique. This technique is robust, cost-efficient and straight-forward to operate comparing to other existing hyperpolarization methods. Though extra endeavor is needed to develop this hyperpolarization technique towards in vivo applications, numerical simulations and experimental results readily show that it can be improved and applied for in vitro chemistry analysis.
ISBN: 9780355907995Subjects--Topical Terms:
1981412
Physical chemistry.
Prolonging and Boosting NMR Signals with Long-lived States and Catalytic Polarization Transfer.
LDR
:03081nmm a2200337 4500
001
2210326
005
20191121124204.5
008
201008s2018 ||||||||||||||||| ||eng d
020
$a
9780355907995
035
$a
(MiAaPQ)AAI10751006
035
$a
(MiAaPQ)duke:14670
035
$a
AAI10751006
040
$a
MiAaPQ
$c
MiAaPQ
100
1
$a
Zhou, Zijian.
$3
3437467
245
1 0
$a
Prolonging and Boosting NMR Signals with Long-lived States and Catalytic Polarization Transfer.
260
1
$a
Ann Arbor :
$b
ProQuest Dissertations & Theses,
$c
2018
300
$a
212 p.
500
$a
Source: Dissertations Abstracts International, Volume: 79-11, Section: B.
500
$a
Publisher info.: Dissertation/Thesis.
500
$a
Advisor: Warren, Warren S.
502
$a
Thesis (Ph.D.)--Duke University, 2018.
506
$a
This item is not available from ProQuest Dissertations & Theses.
506
$a
This item must not be sold to any third party vendors.
520
$a
Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are powerful and versatile tools that are being broadly and intensively used. Their application ranges from molecular structure determination to medical imaging diagnosis. Though NMR and MRI have great advantages such as high chemical environment sensitivity and non-invasive imaging ability with deep penetration, current magnetic resonance (MR) methodologies have fundamental limitations: they mainly use proton as signal source and provide primarily structural information. There are great challenges using MR to obtain metabolic information: for the life supporting elements carbon and nitrogen, their MR non-silent isotopes are in extremely low concentration and the signal they yield is extremely weak under thermal conditions. In addition, their short-lived signal gives us very limited time window to perform complicated experiments. Thus, it is of great significance to obtain long-lived and enhanced NMR and MRI signals for 13C and 15N. Doing so would not only augment information for in vitro chemical analysis, but also make it possible for metabolism monitoring, disease early diagnosis and treatment assessment. This dissertation will first show how we can make the signals long-lived using molecules with specific structures and sophisticated NMR pulses. Then, based on the concept of the long-lived state, it will demonstrate how we can obtain both enhanced and long-lived signals for 13C and 15N spin-pairs with the development of a novel hyperpolarization technique. This technique is robust, cost-efficient and straight-forward to operate comparing to other existing hyperpolarization methods. Though extra endeavor is needed to develop this hyperpolarization technique towards in vivo applications, numerical simulations and experimental results readily show that it can be improved and applied for in vitro chemistry analysis.
590
$a
School code: 0066.
650
4
$a
Physical chemistry.
$3
1981412
650
4
$a
Medical imaging.
$3
3172799
690
$a
0494
690
$a
0574
710
2
$a
Duke University.
$b
Chemistry.
$3
1064507
773
0
$t
Dissertations Abstracts International
$g
79-11B.
790
$a
0066
791
$a
Ph.D.
792
$a
2018
793
$a
English
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10751006
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9386875
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入