東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Proteomic-based Signature of Brain-r...

Begcevic, Ilijana.

FindBook

Google Book

Amazon

博客來

Proteomic-based Signature of Brain-related Proteins as Novel Candidate Biomarkers for Alzheimer's Disease Diagnosis.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Proteomic-based Signature of Brain-related Proteins as Novel Candidate Biomarkers for Alzheimer's Disease Diagnosis./
作者:	Begcevic, Ilijana.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	251 p.
附註:	Source: Dissertations Abstracts International, Volume: 80-02, Section: B.
Contained By:	Dissertations Abstracts International80-02B.
標題:	Medicine. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10639062
ISBN:	9780438186095

Proteomic-based Signature of Brain-related Proteins as Novel Candidate Biomarkers for Alzheimer's Disease Diagnosis.
Begcevic, Ilijana.

Proteomic-based Signature of Brain-related Proteins as Novel Candidate Biomarkers for Alzheimer's Disease Diagnosis. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 251 p.

Source: Dissertations Abstracts International, Volume: 80-02, Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2018.

This item must not be sold to any third party vendors.

Alzheimer's disease (AD) is the most common type of dementia characterized by the progressive memory loss and cognitive decline, with typical age of onset after 65 years. The main disease hallmarks include extracellular amyloid beta deposits and intracellular neurofibrillary tangles. Brain pathology is reflected in cerebrospinal fluid (CSF) where core biomarkers amyloid beta 1-42, total tau, and phosphorylated tau protein levels are changed relative to cognitively normal elderly. There is a need for novel disease-specific biomarkers that will capture disease more accurately and at an earlier stage, predict disease severity, and be used in research and clinical trial settings for patients' enrichment and stratification or to monitor drug efficacy. The aim of the present dissertation is to evaluate diagnostic potential of brain-related proteins in CSF of AD patients. The study was focused on proteins with high specificity for brain tissue. Only proteins expressed predominantly in the brain and reliably identified in the human CSF proteome were selected for development of multiplex mass spectrometry-based assay. Candidate biomarkers were then evaluated in AD patients with different spectrum of disease severity and cognitively healthy individuals (in total 154 subjects). This exploratory study suggests APLP1 protein as a promising biomarker for early AD detection. Specifically, the protein was elevated in mild cognitive impairment compared to cognitively healthy individuals (p<0.001) and was able to discriminate the two groups with high accuracy (AUC: 0.789); this potential was also observed for the multivariate panel of two proteins, APLP1 and SPP1 (AUC: 0.841). Future studies need to validate the biomarkers in a larger, independent cohort including AD, MCI and preclinical AD patients.

ISBN: 9780438186095Subjects--Topical Terms:

641104
Medicine.

Proteomic-based Signature of Brain-related Proteins as Novel Candidate Biomarkers for Alzheimer's Disease Diagnosis.
LDR:02920nmm a2200313 4500 001 2210251
005 20191121124153.5
008 201008s2018 ||||||||||||||||| ||eng d
020 $a 9780438186095
035 $a (MiAaPQ)AAI10639062
035 $a (MiAaPQ)toronto:16818
035 $a AAI10639062
040 $a MiAaPQ $c MiAaPQ
100 1 $a Begcevic, Ilijana. $3 3437393
245 1 0 $a Proteomic-based Signature of Brain-related Proteins as Novel Candidate Biomarkers for Alzheimer's Disease Diagnosis.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 251 p.
500 $a Source: Dissertations Abstracts International, Volume: 80-02, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Diamandis, Eleftherios P.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 2018.
506 $a This item must not be sold to any third party vendors.
520 $a Alzheimer's disease (AD) is the most common type of dementia characterized by the progressive memory loss and cognitive decline, with typical age of onset after 65 years. The main disease hallmarks include extracellular amyloid beta deposits and intracellular neurofibrillary tangles. Brain pathology is reflected in cerebrospinal fluid (CSF) where core biomarkers amyloid beta 1-42, total tau, and phosphorylated tau protein levels are changed relative to cognitively normal elderly. There is a need for novel disease-specific biomarkers that will capture disease more accurately and at an earlier stage, predict disease severity, and be used in research and clinical trial settings for patients' enrichment and stratification or to monitor drug efficacy. The aim of the present dissertation is to evaluate diagnostic potential of brain-related proteins in CSF of AD patients. The study was focused on proteins with high specificity for brain tissue. Only proteins expressed predominantly in the brain and reliably identified in the human CSF proteome were selected for development of multiplex mass spectrometry-based assay. Candidate biomarkers were then evaluated in AD patients with different spectrum of disease severity and cognitively healthy individuals (in total 154 subjects). This exploratory study suggests APLP1 protein as a promising biomarker for early AD detection. Specifically, the protein was elevated in mild cognitive impairment compared to cognitively healthy individuals (p<0.001) and was able to discriminate the two groups with high accuracy (AUC: 0.789); this potential was also observed for the multivariate panel of two proteins, APLP1 and SPP1 (AUC: 0.841). Future studies need to validate the biomarkers in a larger, independent cohort including AD, MCI and preclinical AD patients.
590 $a School code: 0779.
650 4 $a Medicine. $3 641104
690 $a 0564
710 2 $a University of Toronto (Canada). $b Laboratory Medicine and Pathobiology. $3 3193014
773 0 $t Dissertations Abstracts International $g 80-02B.
790 $a 0779
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10639062