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Design Principles for Lab-in-a-Photo...
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Al Rashid, Mohammed Abdullah.
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Design Principles for Lab-in-a-Photonic-Crystal Biosensors.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Design Principles for Lab-in-a-Photonic-Crystal Biosensors./
作者:
Al Rashid, Mohammed Abdullah.
出版者:
Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:
126 p.
附註:
Source: Dissertations Abstracts International, Volume: 80-05, Section: B.
Contained By:
Dissertations Abstracts International80-05B.
標題:
Nanotechnology. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10937604
ISBN:
9780438681415
Design Principles for Lab-in-a-Photonic-Crystal Biosensors.
Al Rashid, Mohammed Abdullah.
Design Principles for Lab-in-a-Photonic-Crystal Biosensors.
- Ann Arbor : ProQuest Dissertations & Theses, 2018 - 126 p.
Source: Dissertations Abstracts International, Volume: 80-05, Section: B.
Thesis (Ph.D.)--University of Toronto (Canada), 2018.
This item must not be sold to any third party vendors.
A new class of photonic crystal biosensors, geared towards rapid biomedical diagnostics at the point-of-care, is proposed. These Lab-in-a-Photonic-Crystal devices employ cascaded transmission of light through a photonic band-gap material by leveraging the interaction of surface modes at entry and exit termini with waveguide modes in centrally-embedded line-defects. A rich spectral signature, composed of conventional resonance-shifts complemented by transmission-level modulation, enables these devices to discriminate between combinations of various bio-markers, attached as thin layers to the surface and line-defect artifacts. An initial two-dimensional conceptual paradigm is proposed, and then developed into a full-fledged, fabrication-feasible, three-dimensional design. The final design consists of a high-index nano-pillar array forming a two-dimensional, fluid-infiltrated photonic crystal with two surface gratings and a central waveguide, whose optical modes are trapped by index-guiding in the third dimension. The nano-pillars are housed in a glass trough, while being open to fluid at the top, allowing easy addition of bio-fluid samples onto the device, and helping prevent clogs due to macroscopic suspended impurities. The design is further optimized, both optically and structurally, by the introduction of a thin-layer of high-index backing material between the nano-pillars and the glass trough substrate, reducing nano-pillar height by half of the unbacked-design height. The system is capable of detecting all eight possible combinations of up to three distinct bio-markers, with the possibility to increase the number of sensed bio-markers through the use of multi-mode waveguides (and potentially, multi-mode surfaces). Using index-guided bulk modes of the three-dimensional structure, a mechanism for calibrating the device under impurity-induced variations in fluid refractive index is proposed. The Lab-in-a-Photonic-Crystal device is suitable for the detection of multiple diseases, or multiple stages of a given disease, in a single optical measurement. Its functionality, as well as robustness to imperfect fabrication, has been validated using Finite-Difference Time-Domain solutions to Maxwell's Equations.
ISBN: 9780438681415Subjects--Topical Terms:
526235
Nanotechnology.
Design Principles for Lab-in-a-Photonic-Crystal Biosensors.
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A new class of photonic crystal biosensors, geared towards rapid biomedical diagnostics at the point-of-care, is proposed. These Lab-in-a-Photonic-Crystal devices employ cascaded transmission of light through a photonic band-gap material by leveraging the interaction of surface modes at entry and exit termini with waveguide modes in centrally-embedded line-defects. A rich spectral signature, composed of conventional resonance-shifts complemented by transmission-level modulation, enables these devices to discriminate between combinations of various bio-markers, attached as thin layers to the surface and line-defect artifacts. An initial two-dimensional conceptual paradigm is proposed, and then developed into a full-fledged, fabrication-feasible, three-dimensional design. The final design consists of a high-index nano-pillar array forming a two-dimensional, fluid-infiltrated photonic crystal with two surface gratings and a central waveguide, whose optical modes are trapped by index-guiding in the third dimension. The nano-pillars are housed in a glass trough, while being open to fluid at the top, allowing easy addition of bio-fluid samples onto the device, and helping prevent clogs due to macroscopic suspended impurities. The design is further optimized, both optically and structurally, by the introduction of a thin-layer of high-index backing material between the nano-pillars and the glass trough substrate, reducing nano-pillar height by half of the unbacked-design height. The system is capable of detecting all eight possible combinations of up to three distinct bio-markers, with the possibility to increase the number of sensed bio-markers through the use of multi-mode waveguides (and potentially, multi-mode surfaces). Using index-guided bulk modes of the three-dimensional structure, a mechanism for calibrating the device under impurity-induced variations in fluid refractive index is proposed. The Lab-in-a-Photonic-Crystal device is suitable for the detection of multiple diseases, or multiple stages of a given disease, in a single optical measurement. Its functionality, as well as robustness to imperfect fabrication, has been validated using Finite-Difference Time-Domain solutions to Maxwell's Equations.
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