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Treatment of Liver Metastasis Via Na...

Goodwin, Tyler Jay.

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Treatment of Liver Metastasis Via Nanoparticle Delivery of Engineered Gene Immunotherapies Expressed Locally and Transiently by the Liver Hepatocytes.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Treatment of Liver Metastasis Via Nanoparticle Delivery of Engineered Gene Immunotherapies Expressed Locally and Transiently by the Liver Hepatocytes./
作者:	Goodwin, Tyler Jay.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
面頁冊數:	145 p.
附註:	Source: Dissertations Abstracts International, Volume: 79-01, Section: B.
Contained By:	Dissertations Abstracts International79-01B.
標題:	Nanoscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10258608
ISBN:	9781369871494

Treatment of Liver Metastasis Via Nanoparticle Delivery of Engineered Gene Immunotherapies Expressed Locally and Transiently by the Liver Hepatocytes.
Goodwin, Tyler Jay.

Treatment of Liver Metastasis Via Nanoparticle Delivery of Engineered Gene Immunotherapies Expressed Locally and Transiently by the Liver Hepatocytes. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 145 p.

Source: Dissertations Abstracts International, Volume: 79-01, Section: B.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2017.

This item is not available from ProQuest Dissertations & Theses.

Recent developments in the field of immunology, gene therapy and nanotechnology have brought new tactics to treat cancers and other acute diseases. Traditional strategies for cancer treatment relies on systemic administration of toxic small molecules. This strategy has been successful in some cancer types, but many cancers return or gain resistance, leaving the patient with a suppressed immune system due to the off-target toxicities from the chemotherapy. Therefore, more elaborate strategies are now being developed to avoid the off-target toxicities, while strengthening the patient's immune response against these cancers. Several of these promising immune boosting therapeutics have now reached the clinic as antibody drugs or cancer vaccines. However, these antibody drugs are still showing signs of off-target toxicities due to the systemic administration. This dissertation research focuses on understanding the basic microenvironment of liver metastasis, the role immune signaling cytokines and chemokines play in the progression of this disease and recruitment of the immune cell populations, as well as investigate the ability to manipulate these immune signals to shift to an anti-tumor microenvironment following nanoparticle gene delivery of a novel Trap technology. The tumor immune microenvironment as well as strategies to modulate the environment will be summarized and discussed in detail. (Abstract shortened by ProQuest.).

ISBN: 9781369871494Subjects--Topical Terms:

587832
Nanoscience.

Treatment of Liver Metastasis Via Nanoparticle Delivery of Engineered Gene Immunotherapies Expressed Locally and Transiently by the Liver Hepatocytes.
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