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Environmental, Pharmacological, and ...

Kucera, Heidi Rebecca.

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Environmental, Pharmacological, and Nutritional influences on Steroidogenesis Profiles in Two Different Animal Model Systems.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Environmental, Pharmacological, and Nutritional influences on Steroidogenesis Profiles in Two Different Animal Model Systems./
Author:	Kucera, Heidi Rebecca.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	140 p.
Notes:	Source: Dissertations Abstracts International, Volume: 80-05, Section: B.
Contained By:	Dissertations Abstracts International80-05B.
Subject:	Obstetrics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10928547
ISBN:	9780438628564

Environmental, Pharmacological, and Nutritional influences on Steroidogenesis Profiles in Two Different Animal Model Systems.
Kucera, Heidi Rebecca.

Environmental, Pharmacological, and Nutritional influences on Steroidogenesis Profiles in Two Different Animal Model Systems. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 140 p.

Source: Dissertations Abstracts International, Volume: 80-05, Section: B.

Thesis (Ph.D.)--University of California, Davis, 2018.

This item must not be sold to any third party vendors.

Hormone-dependent pathways are critical in pregnancy, development, and reproduction throughout all stages of life. For this reason, when alterations are seen in pregnancy, development, and reproduction, hormonal changes are the first pathways investigated, specifically steroid hormones and peptide hormones. This research utilized a broad multi-tissue steroid hormone platform to better understand the importance and function of hormone-pathways in pregnancy, development, and reproduction in the presence of environmental, pharmacological, and nutritional influences. The boar and rat were selected as models for reproduction and maternal/fetal pregnancy outcomes, respectively. All tissue and fluid steroid hormone profiles were measured by ultra-performance liquid chromatography tandem mass spectrometry (UPLC/MS-MS). This is a novel, complex approach to steroid hormone profiling in animal models and the first report of a broad multi-tissue approach to steroid hormone profiling in boars and rats. Data generated demonstrate the existence of unique steroid hormone profiles within each tissue, and how in each organ they can respond differently and/or independently to environmental, pharmacological, and nutritional influences. The chapters contained herein: 1) expand the knowledge of tissue steroid hormone profiles, by exploring both free and conjugated steroids, and 2) examine each tissue as a unique entity that responds differently to nutritional, environmental, and pharmacological/toxicological influences.

ISBN: 9780438628564Subjects--Topical Terms:

634501
Obstetrics.

Environmental, Pharmacological, and Nutritional influences on Steroidogenesis Profiles in Two Different Animal Model Systems.
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245 1 0 $a Environmental, Pharmacological, and Nutritional influences on Steroidogenesis Profiles in Two Different Animal Model Systems.
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500 $a Source: Dissertations Abstracts International, Volume: 80-05, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Lein, Pam.
502 $a Thesis (Ph.D.)--University of California, Davis, 2018.
506 $a This item must not be sold to any third party vendors.
520 $a Hormone-dependent pathways are critical in pregnancy, development, and reproduction throughout all stages of life. For this reason, when alterations are seen in pregnancy, development, and reproduction, hormonal changes are the first pathways investigated, specifically steroid hormones and peptide hormones. This research utilized a broad multi-tissue steroid hormone platform to better understand the importance and function of hormone-pathways in pregnancy, development, and reproduction in the presence of environmental, pharmacological, and nutritional influences. The boar and rat were selected as models for reproduction and maternal/fetal pregnancy outcomes, respectively. All tissue and fluid steroid hormone profiles were measured by ultra-performance liquid chromatography tandem mass spectrometry (UPLC/MS-MS). This is a novel, complex approach to steroid hormone profiling in animal models and the first report of a broad multi-tissue approach to steroid hormone profiling in boars and rats. Data generated demonstrate the existence of unique steroid hormone profiles within each tissue, and how in each organ they can respond differently and/or independently to environmental, pharmacological, and nutritional influences. The chapters contained herein: 1) expand the knowledge of tissue steroid hormone profiles, by exploring both free and conjugated steroids, and 2) examine each tissue as a unique entity that responds differently to nutritional, environmental, and pharmacological/toxicological influences.
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650 4 $a Nutrition. $3 517777
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