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T Cell Immunity and Postpartum Contr...

Coss, Samantha.

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T Cell Immunity and Postpartum Control of the Hepatitis C Virus.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	T Cell Immunity and Postpartum Control of the Hepatitis C Virus./
作者:	Coss, Samantha.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	183 p.
附註:	Source: Dissertations Abstracts International, Volume: 80-08, Section: B.
Contained By:	Dissertations Abstracts International80-08B.
標題:	Cellular biology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13834490
ISBN:	9780438814011

T Cell Immunity and Postpartum Control of the Hepatitis C Virus.
Coss, Samantha.

T Cell Immunity and Postpartum Control of the Hepatitis C Virus. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 183 p.

Source: Dissertations Abstracts International, Volume: 80-08, Section: B.

Thesis (Ph.D.)--The Ohio State University, 2018.

This item must not be sold to any third party vendors.

Chronic infections are detrimental to the adaptive immune response; they induce what is known as immune exhaustion, which is caused by chronic immune activation and characterized by reduced proliferation, progressive immune dysfunction, and potentially deletion of antigen-specific T cells. The hepatitis C virus (HCV) is an ideal model organism for understanding immune exhaustion. Infection with the hepatitis C virus most commonly leads to viral persistence and T cell dysfunction with high, stable levels of viremia. However, women who are chronically infected with HCV often achieve dramatic reductions in HCV viremia following delivery. This phenomenon is not well understood. In particular, while both CD4+ and CD8+ T cells have been shown to be essential for control of acute HCV infection, their roles in spontaneous viral control during chronic hepatitis C have not been fully elucidated. The studies described herein focused on better understanding how a persistent viral pathogen like HCV can be spontaneously controlled during the chronic phase of infection in spite of presumed T cell exhaustion. The main objective was to elucidate the roles of cytotoxic and helper T cells in postpartum control of HCV replication, with a focus on measuring the direct ex vivo activity of CD4+ and CD8+ cells and characterizing the T cell immunophenotype that is associated with viral control. My results provide novel evidence that CD4+ T cells recover function and demonstrate an activated memory phenotype in the postpartum period and suggest that these cells may be contributing to viral control after delivery. More work is needed to elucidate the mechanism by which CD4+ T cell recovery is achieved and the downstream effects of CD4+ T cell function on CD8+ T cells and B cells. However, these findings are novel and unexpected and suggest that CD4+ T cell dysfunction is potentially reversible and that CD4+ T cells are critical for the control of persistent viral pathogens.

ISBN: 9780438814011Subjects--Topical Terms:

3172791
Cellular biology.

T Cell Immunity and Postpartum Control of the Hepatitis C Virus.
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