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Investigation of Small Molecule Medi...

Jones, Corey L.

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Investigation of Small Molecule Mediated Regulation of Proteasome Activity: Computationally Guided Design, Synthesis, and Formulation of a Theoretical Framework for Activity.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Investigation of Small Molecule Mediated Regulation of Proteasome Activity: Computationally Guided Design, Synthesis, and Formulation of a Theoretical Framework for Activity./
作者:	Jones, Corey L.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
面頁冊數:	226 p.
附註:	Source: Dissertation Abstracts International, Volume: 80-09(E), Section: B.
Contained By:	Dissertation Abstracts International80-09B(E).
標題:	Organic chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13860910
ISBN:	9781392146941

Investigation of Small Molecule Mediated Regulation of Proteasome Activity: Computationally Guided Design, Synthesis, and Formulation of a Theoretical Framework for Activity.
Jones, Corey L.

Investigation of Small Molecule Mediated Regulation of Proteasome Activity: Computationally Guided Design, Synthesis, and Formulation of a Theoretical Framework for Activity. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 226 p.

Source: Dissertation Abstracts International, Volume: 80-09(E), Section: B.

Thesis (Ph.D.)--Michigan State University, 2019.

Proteins undergo constant proteolytic degradation to regulate intracellular processes and maintain biological homeostasis. One of the main intracellular proteolytic pathways involves the proteasome, which is responsible for the degradation of misfolded, oxidatively damaged, and redundant proteins. The age-related decline of the efficiency of this enzymatic pathway leads to accumulation of aberrant proteins which leads to aggregates and a host of amyloidosis disease states. Small molecule intervention has been suggested as a viable therapeutic strategy; however, enhancement of proteasome activity is not well understood. This work details efforts and evidence for mechanistic understanding of how small molecule action may enhance and bias proteasome proteolysis and provides a theoretical model for further advancement.

ISBN: 9781392146941Subjects--Topical Terms:

523952
Organic chemistry.

Investigation of Small Molecule Mediated Regulation of Proteasome Activity: Computationally Guided Design, Synthesis, and Formulation of a Theoretical Framework for Activity.
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