東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

The Development of New Catalysts for...

Hu, Bin.

FindBook

Google Book

Amazon

博客來

The Development of New Catalysts for Asymmetric Umpolung Reactions Generating Chiral Amines.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Development of New Catalysts for Asymmetric Umpolung Reactions Generating Chiral Amines./
作者:	Hu, Bin.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2019,
面頁冊數:	398 p.
附註:	Source: Dissertation Abstracts International, Volume: 80-08(E), Section: B.
Contained By:	Dissertation Abstracts International80-08B(E).
標題:	Chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10977919
ISBN:	9781392020234

The Development of New Catalysts for Asymmetric Umpolung Reactions Generating Chiral Amines.
Hu, Bin.

The Development of New Catalysts for Asymmetric Umpolung Reactions Generating Chiral Amines. - Ann Arbor : ProQuest Dissertations & Theses, 2019 - 398 p.

Source: Dissertation Abstracts International, Volume: 80-08(E), Section: B.

Thesis (Ph.D.)--Brandeis University, 2019.

Chiral gamma-amino acids are present as a structural motif in a wide variety of biologically interesting natural products and synthetic compounds. We discovered that novel cinchona alkaloid-derived chiral phase transfer catalysts could enable the highly chemo-, regio-, diastereo-, and enantioselective umpolung addition of trifluoromethyl imines to alpha, beta-unsaturated N-acyl pyrroles. With a catalyst loading ranging from 0.2 to 5.0 mol%, this new catalytic asymmetric transformation provides facile and high-yielding access to highly enantiomerically enriched chiral trifluoromethyl gamma-amino acids and gamma-lactams.

ISBN: 9781392020234Subjects--Topical Terms:

516420
Chemistry.

The Development of New Catalysts for Asymmetric Umpolung Reactions Generating Chiral Amines.
LDR:02535nmm a2200313 4500 001 2204050
005 20190624102128.5
008 201008s2019 ||||||||||||||||| ||eng d
020 $a 9781392020234
035 $a (MiAaPQ)AAI10977919
035 $a (MiAaPQ)brandeis:10774
035 $a AAI10977919
040 $a MiAaPQ $c MiAaPQ
100 1 $a Hu, Bin. $3 2186515
245 1 4 $a The Development of New Catalysts for Asymmetric Umpolung Reactions Generating Chiral Amines.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2019
300 $a 398 p.
500 $a Source: Dissertation Abstracts International, Volume: 80-08(E), Section: B.
500 $a Adviser: Li Deng.
502 $a Thesis (Ph.D.)--Brandeis University, 2019.
520 $a Chiral gamma-amino acids are present as a structural motif in a wide variety of biologically interesting natural products and synthetic compounds. We discovered that novel cinchona alkaloid-derived chiral phase transfer catalysts could enable the highly chemo-, regio-, diastereo-, and enantioselective umpolung addition of trifluoromethyl imines to alpha, beta-unsaturated N-acyl pyrroles. With a catalyst loading ranging from 0.2 to 5.0 mol%, this new catalytic asymmetric transformation provides facile and high-yielding access to highly enantiomerically enriched chiral trifluoromethyl gamma-amino acids and gamma-lactams.
520 $a Cinchona alkaloid-derived chiral catalysts represent one of the most widely applied class of organocatalysts in asymmetric synthesis which have been successfully utilized in the promotion of a wide variety of asymmetric reactions. Due to the structurally pseudoenantiomeric properties, these catalysts could also fail to mediate the formation of desired both enantiomers with similarly high enantioselectivities and yields. Based on several key insights gained from X-ray crystal structural studies, we described here an unprecedented general modification of these natural cinchona scaffold which enabled us to realize a series of highly efficient and enantioselective reactions for the direct generation of opposite enantiomers in high yields and enantioselectivities. More impressively, these newly developed catalysts demonstrated significantly improved catalytic capability compared with all the natural-originated cinchona catalysts.
590 $a School code: 0021.
650 4 $a Chemistry. $3 516420
650 4 $a Organic chemistry. $3 523952
690 $a 0485
690 $a 0490
710 2 $a Brandeis University. $b Chemistry. $3 1669782
773 0 $t Dissertation Abstracts International $g 80-08B(E).
790 $a 0021
791 $a Ph.D.
792 $a 2019
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10977919