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New Chemical Synthesis Methods via C...

Schwarz, Kevin J.

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New Chemical Synthesis Methods via Cooperative Catalysis: Merging C1-Ammonium Enolates with Transition Metal Electrophiles.

Record Type:	Electronic resources : Monograph/item
Title/Author:	New Chemical Synthesis Methods via Cooperative Catalysis: Merging C1-Ammonium Enolates with Transition Metal Electrophiles./
Author:	Schwarz, Kevin J.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	408 p.
Notes:	Source: Dissertation Abstracts International, Volume: 80-03(E), Section: B.
Contained By:	Dissertation Abstracts International80-03B(E).
Subject:	Organic chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10934989
ISBN:	9780438508415

New Chemical Synthesis Methods via Cooperative Catalysis: Merging C1-Ammonium Enolates with Transition Metal Electrophiles.
Schwarz, Kevin J.

New Chemical Synthesis Methods via Cooperative Catalysis: Merging C1-Ammonium Enolates with Transition Metal Electrophiles. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 408 p.

Source: Dissertation Abstracts International, Volume: 80-03(E), Section: B.

Thesis (Ph.D.)--Indiana University, 2018.

The preparation of complex enantioenriched molecular scaffolds is an essential and yet extremely challenging aspect of pharmaceutical and materials research. Asymmetric catalysis is a versatile and potentially economic alternative to stoichiometric reagent control; however, it is becoming increasingly difficult to conceive of and develop distinct and general substrate activation modes for catalyst design. Cooperative catalysis, wherein two or more catalysts work in concert to afford a single chemical transformation, has emerged as a powerful mechanistic approach to reaction design. Attracted by this potentially expansive approach, we questioned whether this concept might be harnessed to develop a potentially general solution to the long-standing challenge of direct, catalytic, asymmetric alpha-functionalization of linear prochiral esters. To address this, we have unified C1-ammonium enolate nucleophiles and transition metal electrophiles within a cooperative regime. Furthermore, this series of investigations has resulted in a number of catalytic asymmetric methods for alpha-alkylation of linear prochiral esters.

ISBN: 9780438508415Subjects--Topical Terms:

523952
Organic chemistry.

New Chemical Synthesis Methods via Cooperative Catalysis: Merging C1-Ammonium Enolates with Transition Metal Electrophiles.
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500 $a Source: Dissertation Abstracts International, Volume: 80-03(E), Section: B.
500 $a Adviser: Thomas N. Snaddon.
502 $a Thesis (Ph.D.)--Indiana University, 2018.
520 $a The preparation of complex enantioenriched molecular scaffolds is an essential and yet extremely challenging aspect of pharmaceutical and materials research. Asymmetric catalysis is a versatile and potentially economic alternative to stoichiometric reagent control; however, it is becoming increasingly difficult to conceive of and develop distinct and general substrate activation modes for catalyst design. Cooperative catalysis, wherein two or more catalysts work in concert to afford a single chemical transformation, has emerged as a powerful mechanistic approach to reaction design. Attracted by this potentially expansive approach, we questioned whether this concept might be harnessed to develop a potentially general solution to the long-standing challenge of direct, catalytic, asymmetric alpha-functionalization of linear prochiral esters. To address this, we have unified C1-ammonium enolate nucleophiles and transition metal electrophiles within a cooperative regime. Furthermore, this series of investigations has resulted in a number of catalytic asymmetric methods for alpha-alkylation of linear prochiral esters.
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