東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Making and Breaking C--F Bonds via P...

Thornbury, Richard Tresslar.

Linked to FindBook

Google Book

Amazon

博客來

Making and Breaking C--F Bonds via Palladium-Catalysis.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Making and Breaking C--F Bonds via Palladium-Catalysis./
Author:	Thornbury, Richard Tresslar.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	215 p.
Notes:	Source: Dissertation Abstracts International, Volume: 80-03(E), Section: B.
Contained By:	Dissertation Abstracts International80-03B(E).
Subject:	Organic chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10813662
ISBN:	9780438653979

Making and Breaking C--F Bonds via Palladium-Catalysis.
Thornbury, Richard Tresslar.

Making and Breaking C--F Bonds via Palladium-Catalysis. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 215 p.

Source: Dissertation Abstracts International, Volume: 80-03(E), Section: B.

Thesis (Ph.D.)--University of California, Berkeley, 2018.

Chapter 1: A ligand controlled, palladium-catalyzed, enantioselective 1,3-arylfluorination of [2H]-chromenes was developed. The products were obtained in high enantioselectivity and with a syn- relationship of the introduced substituents. The pyranyl fluoride products were further derivatized to demonstrate the utility of the products. A ligand dependent divergent formation of 1,3- and 2,1- alkene difunctionalization products was also observed. This bifurcation in reactivity was investigated with a combination of experimental, computational, and statistical analysis tools. Ultimately, the site selectivity was found to be dependent on the ligand denticity and metal electrophilicity, the electronics of the boronic acid, and the donor ability of the directing group in the substrate.

ISBN: 9780438653979Subjects--Topical Terms:

523952
Organic chemistry.

Making and Breaking C--F Bonds via Palladium-Catalysis.
LDR:02391nmm a2200313 4500 001 2202715
005 20190513114839.5
008 201008s2018 ||||||||||||||||| ||eng d
020 $a 9780438653979
035 $a (MiAaPQ)AAI10813662
035 $a (MiAaPQ)berkeley:17775
035 $a AAI10813662
040 $a MiAaPQ $c MiAaPQ
100 1 $a Thornbury, Richard Tresslar. $3 3429486
245 1 0 $a Making and Breaking C--F Bonds via Palladium-Catalysis.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 215 p.
500 $a Source: Dissertation Abstracts International, Volume: 80-03(E), Section: B.
500 $a Adviser: Dean Toste.
502 $a Thesis (Ph.D.)--University of California, Berkeley, 2018.
520 $a Chapter 1: A ligand controlled, palladium-catalyzed, enantioselective 1,3-arylfluorination of [2H]-chromenes was developed. The products were obtained in high enantioselectivity and with a syn- relationship of the introduced substituents. The pyranyl fluoride products were further derivatized to demonstrate the utility of the products. A ligand dependent divergent formation of 1,3- and 2,1- alkene difunctionalization products was also observed. This bifurcation in reactivity was investigated with a combination of experimental, computational, and statistical analysis tools. Ultimately, the site selectivity was found to be dependent on the ligand denticity and metal electrophilicity, the electronics of the boronic acid, and the donor ability of the directing group in the substrate.
520 $a Chapter 2: A palladium-catalyzed defluorinative coupling of 1-aryl-2,2-difluoroalkenes with boronic acids was developed. Broad functional tolerance arises from a redox-neutral process in which a palladium(II) active species which is proposed to undergo a beta-fluoride elimination to afford the products. The monofluorostilbene products were formed with excellent diastereoselectivity (≥ 50:1) in all cases. As a demonstration of this method's unique combination of reactivity and functional group tolerance, a GleevecRTM analogue, using a monofluorostilbene as an amide isostere, was synthesized in 4 steps from commercially available materials.
590 $a School code: 0028.
650 4 $a Organic chemistry. $3 523952
650 4 $a Chemistry. $3 516420
690 $a 0490
690 $a 0485
710 2 $a University of California, Berkeley. $b Chemistry. $3 1674000
773 0 $t Dissertation Abstracts International $g 80-03B(E).
790 $a 0028
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10813662