東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Small-molecule TLR8 Antagonists via ...

Hu, Zhenyi.

FindBook

Google Book

Amazon

博客來

Small-molecule TLR8 Antagonists via Structure-based Rational Design.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Small-molecule TLR8 Antagonists via Structure-based Rational Design./
作者:	Hu, Zhenyi.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	262 p.
附註:	Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B.
Contained By:	Dissertation Abstracts International80-02B(E).
標題:	Chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10846134
ISBN:	9780438384057

Small-molecule TLR8 Antagonists via Structure-based Rational Design.
Hu, Zhenyi.

Small-molecule TLR8 Antagonists via Structure-based Rational Design. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 262 p.

Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B.

Thesis (Ph.D.)--University of Colorado at Boulder, 2018.

Immune system plays a critical role in defense against various virus and bacteria, and it's composed of innate immune system and adaptive immune system. Innate immune system is vital for immune response because of its prompt responses to a variety of pathogens as well as its selectivity for targeting only pathogens not the host. The innate immune system achieves this by using receptors to recognize certain molecular patterns that are common in many pathogens but are not present in the host. These receptors are known as pattern recognition receptors (PRR), they can recognize pathogen-associated molecular pattern (PAMP) as well as damage-associated molecular pattern (DAMP).

ISBN: 9780438384057Subjects--Topical Terms:

516420
Chemistry.

Small-molecule TLR8 Antagonists via Structure-based Rational Design.
LDR:02786nmm a2200361 4500 001 2202029
005 20190503113355.5
008 201008s2018 ||||||||||||||||| ||eng d
020 $a 9780438384057
035 $a (MiAaPQ)AAI10846134
035 $a (MiAaPQ)colorado:15647
035 $a AAI10846134
040 $a MiAaPQ $c MiAaPQ
100 1 $a Hu, Zhenyi. $3 3428782
245 1 0 $a Small-molecule TLR8 Antagonists via Structure-based Rational Design.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 262 p.
500 $a Source: Dissertation Abstracts International, Volume: 80-02(E), Section: B.
500 $a Adviser: Hang Yin.
502 $a Thesis (Ph.D.)--University of Colorado at Boulder, 2018.
520 $a Immune system plays a critical role in defense against various virus and bacteria, and it's composed of innate immune system and adaptive immune system. Innate immune system is vital for immune response because of its prompt responses to a variety of pathogens as well as its selectivity for targeting only pathogens not the host. The innate immune system achieves this by using receptors to recognize certain molecular patterns that are common in many pathogens but are not present in the host. These receptors are known as pattern recognition receptors (PRR), they can recognize pathogen-associated molecular pattern (PAMP) as well as damage-associated molecular pattern (DAMP).
520 $a Among pattern recognition receptors, Toll-like receptors (TLRs) are the most well studied ones. Toll-like receptors (TLRs) play a key role in the innate immune system by recognizing structurally conserved PAMP and DAMP. The goal of this doctoral dissertation research is to design, synthesis and evaluate TLR8 antagonists.
520 $a Chapter 1 focus on introduction of immune system including innate immune system and adaptive immune system. Pattern recognition receptors are then introduced, and Toll-like receptors are specially focused on.
520 $a Chapter 2 describes the design and development of TLR8 antagonist utilizing structure-based rational design. And Structure--Activity Relationship (SAR) study of TLR8 antagonists is introduced in chapter 3.
520 $a Chapter 4 describes the mechanism of TLR8 inhibition induced by CU-CPT antagonists. Chapter 5 introduces biological validation of CU-CPT antagonists, showing high potency and selectivity of these compounds, which indicates the therapeutic potential of CU-CPT derivatives. Methods and supporting information are listed in Chapter 6 and 7.
590 $a School code: 0051.
650 4 $a Chemistry. $3 516420
650 4 $a Organic chemistry. $3 523952
650 4 $a Molecular chemistry. $3 1071612
690 $a 0485
690 $a 0490
690 $a 0431
710 2 $a University of Colorado at Boulder. $b Chemistry. $3 1019559
773 0 $t Dissertation Abstracts International $g 80-02B(E).
790 $a 0051
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10846134